Amyloid-β peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer’s disease

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

The metallobiology of Alzheimer's disease

2003 • 1,256 citations

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

2005 • 1,206 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

2000 • 526 citations

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

2001 • 510 citations

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

1994 • 502 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

2004 • 457 citations

Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

2004 • 429 citations

NPAS2: A Gas-Responsive Transcription Factor

2002 • 422 citations

Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants

2005 • 373 citations

Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease

1992 • 367 citations

Direct Observation of Amyloid Fibril Growth Monitored by Thioflavin T Fluorescence

2003 • 337 citations

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture

1998 • 285 citations

A role for heme in Alzheimer's disease: Heme binds amyloid β and has altered metabolism

2004 • 239 citations

Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins.

1984 • 220 citations

Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging

2002 • 220 citations

Evidence for the Presence of Three Distinct Binding Sites for the Thioflavin T Class of Alzheimer's Disease PET Imaging Agents on β-Amyloid Peptide Fibrils

2004 • 205 citations

Structure–Function Relationships in Heme-Proteins

2002 • 178 citations

Abnormal localization of iron regulatory protein in Alzheimer's disease

1998 • 170 citations

Mechanism of Iron Transport to the Site of Heme Synthesis inside Yeast Mitochondria

1999 • 166 citations

Heme Deficiency Selectively Interrupts Assembly of Mitochondrial Complex IV in Human Fibroblasts

2001 • 163 citations

Heme, iron, and the mitochondrial decay of ageing

2004 • 158 citations

Metabolic, Metallic, and Mitotic Sources of Oxidative Stress in Alzheimer Disease

2000 • 155 citations

Age-Dependent Change in the Levels of Aβ40 and Aβ42 in Cerebrospinal Fluid from Control Subjects, and a Decrease in the Ratio of Aβ42 to Aβ40 Level in Cerebrospinal Fluid from Alzheimer’s Disease Patients

2000 • 113 citations

The Role of Heme and Iron-Sulfur Clusters in Mitochondrial Biogenesis, Maintenance, and Decay with Age

2002 • 113 citations

Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging

2005 • 112 citations

Hemin and related porphyrins inhibit β‐amyloid aggregation

1997 • 98 citations

δ-Aminolevulinic Acid Synthetase and the Control of Heme and Chlorophyll Synthesis**This review was aided by grants from the National Institutes of Health, GM-04922, and from the National Science Foundation, GB-6818.††Abbreviations: AA, aminoacetone; AIA, allyl isopropyl acetamide (an inducing chemical); AIP, acute intermittent porphyria; ALA, δ-aminolevulinic acid; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; ELB, early labeled bilirubin; Heme, ferrous or ferric iron protoporphyrin; Hemin, …

1971 • 75 citations

Heme binding to Amyloid-β peptide: Mechanistic role in Alzheimer's disease

2006 • 74 citations

Crystal Structures of Cyanide- and Triiodide-bound Forms of Arthromyces ramosus Peroxidase at Different pH Values

1995 • 73 citations

Identification of Novel Hemes Generated by Heme A Synthase: Evidence for Two Successive Monooxygenase Reactions

2002 • 66 citations

Functional Neurochemistry of Alzheimers Disease

2004 • 65 citations

Inactivation of the human brain muscarinic acetylcholine receptor by oxidative damage catalyzed by a low molecular weight endogenous inhibitor from Alzheimer’s brain is prevented by pyrophosphate analogs, bioflavonoids and other antioxidants

2002 • 64 citations

Human Ferrochelatase: Characterization of Substrate−Iron Binding and Proton-Abstracting Residues

2001 • 63 citations

Evidence for the sequential assembly of cytochrome oxidase subunits in rat liver mitochondria

1983 • 61 citations

Cytosolic modulators of activities of microsomal enzymes of cholesterol biosynthesis effects of acyl-CoA inhibition and cytosolic Z-protein

1983 • 61 citations

Soluble δ-Aminolevulinic Acid Synthetase of Rat Liver

1972 • 60 citations

Serotonin Acts as a Radical Scavenger and Is Oxidized to a Dimer During the Respiratory Burst of Activated Microglia

1997 • 56 citations

Elevated brain tryptophan and enhanced 5-hydroxytryptamine turnover in acute hepatic heme deficiency: clinical implications.

1985 • 53 citations

Involvement of Heme in the Degradation of Iron-regulatory Protein 2

1998 • 48 citations

Kinetics of oxidation of serotonin by myeloperoxidase compounds I and II

1999 • 36 citations

Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency.

1988 • 34 citations

Accumulation of heme in mitochondria from rabbit reticulocytes with inhibited globin synthesis

1973 • 34 citations

Heme inhibits transferrin endocytosis in immature erythroid cells

1984 • 30 citations

The solution structure and heme binding of the presequence of murine 5‐aminolevulinate synthase

2001 • 29 citations

Ferric Cycle Activity and Alzheimer Disease

2005 • 13 citations