δ-Aminolevulinic Acid Synthetase and the Control of Heme and Chlorophyll Synthesis**This review was aided by grants from the National Institutes of Health, GM-04922, and from the National Science Foundation, GB-6818.††Abbreviations: AA, aminoacetone; AIA, allyl isopropyl acetamide (an inducing chemical); AIP, acute intermittent porphyria; ALA, δ-aminolevulinic acid; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; ELB, early labeled bilirubin; Heme, ferrous or ferric iron protoporphyrin; Hemin, …

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

1968 • 1,767 citations

THE OCCURRENCE AND DETERMINATION OF δ-AMINOLEVULINIC ACID AND PORPHOBILINOGEN IN URINE

1956 • 1,554 citations

ENZYMATIC PROPERTIES OF THE INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIA

1968 • 1,398 citations

Porphyrins and Metalloporphyrins

1964 • 994 citations

The Induction in Vitro of the Synthesis of δ-Aminolevulinic Acid Synthetase in Chemical Porphyria: A Response to Certain Drugs, Sex Hormones, and Foreign Chemicals

1966 • 764 citations

Control of Specific Gene Expression in Higher Organisms

1969 • 544 citations

Hydroxylation-Induced Migration: The NIH Shift

1967 • 519 citations

STUDIES ON THE FREE AMINO ACIDS AND RELATED COMPOUNDS IN THE TISSUES OF THE CAT

1954 • 476 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Microsomes and drug oxidation

1969 • 451 citations

Increase in Activity of δ-Aminolevulinic Acid Synthetase in Liver Mitochondria Induced by Feeding of 3, 5-Dicarbethoxy-1, 4-dihydrocollidine

1963 • 431 citations

Mechanism of Activation of Catabolite-Sensitive Genes: A Positive Control System

1970 • 430 citations

Hemoglobin and Myoglobin

1964 • 407 citations

The Importance of Both Synthesis and Degradation in the Control of Arginase Levels in Rat Liver

1964 • 396 citations

Mitochondrial Coproporphyrinogen Oxidase and Protoporphyrin Formation

1961 • 344 citations

The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning

1966 • 327 citations

δ-Aminolevulinic Acid Synthetase

1966 • 307 citations

Biosynthesis of α-Aminoketones and the Metabolism of Aminoacetone

1963 • 306 citations

The Enzymatic Synthesis of δ-Aminolevulinic Acid

1958 • 300 citations

Control of Porphyrin Biosynthesis through a Negative-Feedback Mechanism. STUDIES WITH PREPARATIONS OF δ-AMINOLAEVULATE SYNTHETASE AND δ-AMINOLAEVULATE DEHYDRATASE FROM RHODOPSEUDOMONAS SPHEROIDES

1963 • 294 citations

δ-Aminolevulinic Acid Synthetase

1966 • 289 citations

Acquired Toxic Porphyria Cutanea Tarda Due to Hexachlorobenzene

1963 • 286 citations

ON THE ORIGIN OF BILE PIGMENT IN NORMAL MAN

1950 • 260 citations

Initial stages in the biosynthesis of porphyrins. 2. The formation of δ-aminolaevulic acid from glycine and succinyl-coenzyme A by particles from chicken erythrocytes

1958 • 247 citations

The structural organization of haem synthesis in rat liver mitochondria

1969 • 231 citations

PORPHYRIN BIOSYNTHESIS IN ERYTHROCYTES

1958 • 225 citations

Effects of Phenobarbital on the Synthesis and Degradation of the Protein Components of Rat Liver Microsomal Membranes

1969 • 223 citations

Industrially Acquired Porphyria

1964 • 210 citations

Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide

1970 • 186 citations

ACUTE INTERMITTENT PORPHYRIA: THE FIRST “OVERPRODUCTION DISEASE” LOCALIZED TO A SPECIFIC ENZYME

1965 • 183 citations

The composition of the ketoglutarate dehydrogenase complex

1960 • 166 citations

Steroid Induction of Porphyrin Synthesis in Liver Cell Culture

1967 • 156 citations

Induction of δ-Aminolevulinic Acid Synthetase in Chick Embryo Liver Cells in Culture

1970 • 151 citations

Controls on Chlorophyll Synthesis in Barley

1970 • 149 citations

Steroid Induction of Porphyrin Synthesis in Liver Cell Culture

1968 • 145 citations

DISTURBANCE OF PORPHYRIN METABOLISM CAUSED BY GRISEOFULVIN IN MICE.

1963 • 142 citations

Studies in congenital porphyria. 2. Incorporation of 15N in the stercobilin in the normal and in the porphyric

1950 • 141 citations

Behavior of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver

1968 • 132 citations

Independent Genetic Control of the Catalytic Activity and the Rate of Degradation of Catalase in Mice

1969 • 126 citations

Disturbances of liver porphyrin metabolism caused by drugs.

1967 • 124 citations

The determination of aminoketones in biological fluids

1966 • 123 citations

Tetrapyrrole biosynthesis and its regulation

1965 • 122 citations

Factors affecting the excretion of porphyrin precursors by patients with acute intermittent porphyria I. The effect of diet

1964 • 121 citations

The Metabolism of Mitochondrial Proteins

1968 • 120 citations

Induction of the Synthesis of δ-Amino-levulinic Acid Synthetase in Liver Parenchyma Cells in Culture by Chemicals That Induce Acute Porphyria

1963 • 118 citations

Possible Role of P-450 in the Oxidation of Drugs in Liver Microsomes*

1966 • 117 citations

The Genetic and Developmental Regulation of Hepatic δ-Aminolevulinate Dehydratase in Mice

1969 • 115 citations

The Biosynthesis of δ-Aminolevulinic Acid in Chlorella

1970 • 108 citations

Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids.

1967 • 107 citations

Turnover of Cytochromes Labeled with δ-Aminolevulinic Acid-3H in Rat Liver

1969 • 107 citations

Alterations in the Nature of Ribonucleic Acid Synthesized in Rat Liver during Regeneration and after Cortisol Administration

1967 • 107 citations

Enhanced formation of rapidly labeled bilirubin by phenobarbital: Hepatic microsomal cytochromes as a possible source

1966 • 105 citations

Chemically Induced Porphyria: Increased Microsomal Heme Turnover after Treatment with Allylisopropylacetamide

1971 • 99 citations

Mode of Action of Glucocorticoids

1964 • 98 citations

Hemin-deficient mutants of Escherichia coli K-12

1968 • 96 citations

The Role of Ribonucleic Acid and Protein Synthesis in Microsomal Aryl Hydrocarbon Hydroxylase Induction in Cell Culture

1970 • 95 citations

Mechanism of allylisopropylacetamide-induced increase of δ-aminolevulinate synthetase in liver mitochondria

1969 • 92 citations

Stimulation of Mammalian Erythropoiesis by 5β-H Steroid Metabolites

1970 • 91 citations

Intramitochondrial localization of δ-aminolaevulate synthetase and ferrochelatase in rat liver

1969 • 89 citations

Rapid loss of cytochrome P‐450 and haem caused in the liver microsomes by the porphyrogenic agent 2‐allyl‐2‐isopropylacetamide

1970 • 89 citations

Translational Control of Gene Expression

1966 • 86 citations

INHIBITION OF BILIRUBIN CONJUGATION IN RAT LIVER SLICES BY HUMAN PREGNANCY AND NEONATAL SERUM AND STEROIDS

1958 • 86 citations

Activity of Amino-laevulinic Acid Synthetase in Normal and Porphyric Human Livers

1966 • 82 citations

Synthesis of microsomal membranes and their enzymic constituents in developing rat liver

1965 • 81 citations

GRISEOFULVIN ADMINISTRATION AND PORPHYRIN METABOLISM

1963 • 79 citations

A Sensitive Radiochemical Assay Method for δ-Aminolevulinic Acid Synthetase

1969 • 77 citations

Purification and Properties of δ-Aminolevulinate Dehydratase from Tissues of Two Strains of Mice

1966 • 76 citations

Studies on the Control of Hemoglobin Synthesis: The in vitro Stimulating Effect of a 5β-H Steroid Metabolite on Heme Formation in Human Bone Marrow Cells

1969 • 75 citations

Control of Hemoglobin Synthesis in the Cultured Chick Blastoderm

1967 • 73 citations

Experimental porphyria in rats induced by chlorinated benzenes

1963 • 73 citations

Oscillations of hepatic δ-aminolevulinic acid synthetase produced in, vivo by heme

1966 • 73 citations

Biosynthesis of Cytochrome c. The Sites of Synthesis of Apoprotein and Holoenzyme

1970 • 69 citations

Inhibition of Gluconeogenesis by Butylmalonate in Perfused Rat Liver

1970 • 69 citations

A simple micro method for the direct determination of δ-amino[14Clevulinic acid production in murine spleen and liver homogenates

1970 • 69 citations

HEME SYNTHESIS IN VITAMIN B6 AND PANTOTHENIC ACID DEFICIENCIES

1957 • 68 citations

The nonerythropoietic component of early bilirubin

1968 • 67 citations

Biosynthesis of Porphyrins and Chlorophylls

1961 • 64 citations

Control of hemoglobin synthesis in the cultured chick blastoderm by delta-aminolevulinic acid synthetase: increase in the rate of hemoglobin formation with delta-aminolevulinic acid.

1965 • 62 citations

Effect of diet on induction of experimental porphyria.

1961 • 62 citations

A model for calculating messenger RNA half-life: Short lived messenger RNA in the induction of mammalian δ-aminolevulinic acid synthetase

1965 • 60 citations

2,4-Bis-(β-hydroxypropionic Acid) Deuteroporphyrinogen IX, a Possible Intermediate between Coproporphyrinogen III and Protoporphyrin IX

1966 • 59 citations

Studies on the induction of hepatic δ-aminolevulinic acid synthetase in rat liver mitochondria

1970 • 58 citations

Coproporphyrinogenase activity in extracts from rhodopseudomonas spheroides

1969 • 57 citations

Mutant Strains of Rhodopseudomonas spheroides Lacking δ-Aminolevulinate Synthase: Growth, Heme, and Bacteriochlorophyll Synthesis

1969 • 57 citations

Aspects of the metabolism of glycine and of porphyrins. The second Hopkins Memorial Lecture

1961 • 56 citations

Bacteriochlorophyll and Heme Synthesis in Rhodopseudomonas spheroides : Possible Role of Heme in Regulation of the Branched Biosynthetic Pathway

1969 • 56 citations

THE INDUCTION OF δ-AMINOLEVULINIC ACID SYNTHETASE in vivo IN CHICK EMBRYO LIVER BY NATURAL STEROIDS

1968 • 55 citations

Control Mechanisms in Developmental Processes

1968 • 54 citations

Isolation, structure and synthesis of a tricarboxylic porphyrin from the harderian glands of the rat

1970 • 54 citations

Erythropoietic Activity of Steroid Metabolites in Mice

1970 • 53 citations

Characterization and measurement of Δ-aminolaevulinate synthetase in bone marrow cell mitochondria

1968 • 50 citations

Mammary Alveolar Epithelial Cells: Effect of Hydrocortisone on Ultrastructure

1969 • 48 citations

γ,δ-Dioxovalerate aminotransferase activity in Rhodopseudomonas spheroides

1963 • 47 citations

Linear sequential arrangement of genes for the biosynthetic pathway of protoheme in Staphylococcus aureus.

1968 • 46 citations

Urinary Excretion of Porphyrin Precursors and Coproporphyrin in Healthy Females on Oral Contraceptives

1966 • 46 citations

EXCESSIVE URINARY EXCRETION OF CERTAIN PORPHYRINOGENIC STEROIDS IN HUMAN ACUTE INTERMITTENT PORPHYRIA

1969 • 44 citations

Control of δ-aminolaevulate synthetase activity in Rhodopseudomonas spheroides

1969 • 43 citations

Heme Synthesis in Iron-deficient Duck Blood

1960 • 38 citations

On the Biosynthesis of Vitamin B12

1963 • 38 citations

Insecticide-Cytoplasmic Interactions in Insects and Vertebrates

1968 • 37 citations

Utilization of Porphobilinogen Carbon-14 in Biosynthesis of Vitamin B ₁₂

1959 • 36 citations

Mechanism of allylisopropylacetamide-induced increase of δ-aminolevulinate synthetase in rat-liver mitochondria

1966 • 36 citations

Bile Pigment Formation in Plants

1970 • 34 citations

Mechanism of allylisopropylacetamide-induced increase of δ-aminolevulinate synthetase in liver mitochondria

1968 • 34 citations

Electron microscopic observations of the early effects of cortisol on the liver cell of the adrenalectomized rat

1968 • 32 citations

HYPERTROPHY OF LIVER CELL SMOOTH SURFACED RETICULUM FOLLOWING PROGESTERONE ADMINISTRATION

1968 • 30 citations

Hepatic δ‐Aminolaevulinic Acid Synthetase Activity in Symptomatic Porphyria

1968 • 29 citations

Presence of Apo-cytochrome b5 in Microsomes from Rat Liver*

1970 • 29 citations

Biochemical changes in rat liver in response to treatment with drugs and other agents—I

1969 • 28 citations

Difference in Molecular Sizes of δ-Aminolevulinate Synthetases in the Soluble and Mitochondrial Fractions of Rat Liver*

1970 • 28 citations

Regulation of Tyrosine Transaminase in the Isolated Perfused Rat Liver

1969 • 27 citations

Mechanism of Inhibition by Hemin of Increase of δ-Aminolevulinate Synthetase in Liver Mittochondria*

1970 • 26 citations

The biosynthesis of porphyrins

1957 • 26 citations

Intramitochondrial localization of 5-aminolaevulinate synthase induced in rat liver with allylisopropylacetamide

1969 • 26 citations

Growth and cytochrome synthesis in a hemin-requiring mutant of Spirillum itersonii

1969 • 25 citations

Occurrence of a specific and reversible inhibitor of δ-aminolevulinate synthetase in extracts of Rhodopseudomonas spheroides

1969 • 25 citations

Presence of—Apo-cytochrome b5 in Microsomes

1970 • 24 citations

Effect of inhibitors of DNA synthesis on allylisopropylacetamide-induced increases of δ-aminolevulinic acid synthetase and other enzymes in rat liver

1965 • 22 citations

Identification of Glucaro-1, 4-lactone in Bile as a Factor Responsible for Inhibitory Effect of Bile on Bacterial β-Glucuronidase

1965 • 22 citations

THE OCCURRENCE OF SUBSTANCES IN HUMAN PLASMA CAPABLE OF INDUCING THE ENZYME δ-AMINOLEVULINATE SYNTHETASE IN LIVER CELLS

1969 • 21 citations

Activation of δ-aminolaevulate synthetase in extracts of Rhodopseudomonas spheroides

1970 • 21 citations

The Role of Heme in the Regulation of δ‐Aminolevulinic Acid and Heme Synthesis in Rabbit Reticulocytes

1969 • 19 citations

286. α-Amino-β-keto-acids. Part I. Synthesis and attempted isolation of the free acids

1959 • 18 citations

Porphyria--'the royal malady'.

1969 • 15 citations

Increased synthesis of l-ascorbic acid caused by drugs which induce porphyria

1964 • 15 citations

Porphyrines et porphyries

2011 • 14 citations

Utilization of propionate for heme synthesis in human bone marrow cells in vitro.

1968 • 12 citations

A model for calculating enzyme synthetic rates during induction: Application to the synergistic effect of ferric citrate on the induction of hepatic δ-aminolevulinic acid synthetase

1969 • 9 citations

Nomenclature and Structure of 1,2,3,4,5,6-Hexachlorocyclohexanes

1955 • 8 citations

Drug-induced porphyrin biosynthesis—I. The effect of porphyria-inducing drugs on N-demethylase activity of chick embryo liver

1969 • 8 citations

Semimicroassay method for hepatic delta-aminolevulinic acid synthetase activity.

1970 • 7 citations

Effects of inducer substances on porphyrin synthesis in liver cell cultures

1968 • 7 citations

[Transformation of protochlorophyll-holochrome by monochromatic light in conditions of initial predominance of the 634 form].

1968 • 5 citations

The effect of phenobarbitone on the incorporation of delta-aminolaevulinic acid into rat liver microsomes

1969 • 4 citations

Porphyrins and related compounds

1978 • 4 citations

ROLE OF RIBONUCLEIC ACID IN EXPERIMENTAL PORPHYRIA

1967 • 2 citations