Management of treatment resistance in schizophrenia

The Brief Psychiatric Rating Scale

1962 • 10,683 citations

ECDEU Assessment Manual for Psychopharmacology

1976 • 8,729 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Physicians Desk Reference

1994 • 2,653 citations

ECDEU Assessment Manual

1976 • 1,644 citations

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

Risperidone in the treatment of schizophrenia

1994 • 1,205 citations

Determinants of Medication Compliance in Schizophrenia: Empirical and Clinical Findings

1997 • 985 citations

A Canadian Multicenter Placebo-Controlled Study of Fixed Doses of Risperidone and Haloperidol in the Treatment of Chronic Schizophrenic Patients

1993 • 884 citations

Catching Up on Schizophrenia

2000 • 815 citations

Olanzapine versus Placebo and Haloperidol

1996 • 788 citations

Multiple fixed doses of “Seroquel” (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo

1997 • 756 citations

The Effects of Risperidone on the Five Dimensions of Schizophrenia Derived by Factor Analysis

1997 • 705 citations

Effectiveness of Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia: A Review and Meta-Analysis of Randomized Trials

2001 • 631 citations

A Selective Review of Recent North American Long-term Followup Studies of Schizophrenia

1988 • 556 citations

Significance of Neuroleptic Dose and Plasma Level in the Pharmacological Treatment of Psychoses

1988 • 554 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1970 • 534 citations

Reduction of suicidality during clozapine treatment of neuroleptic- resistant schizophrenia: impact on risk-benefit assessment

1995 • 446 citations

Mental Disorders and Homicidal Behavior in Finland

1996 • 439 citations

Lithium Carbonate, Haloperidol, and Irreversible Brain Damage

1974 • 392 citations

Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome

1994 • 380 citations

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia

1992 • 356 citations

Effects of Six Months of Clozapine Treatment on the Quality of Life of Chronic Schizophrenic Patients

1990 • 351 citations

Electroconvulsive therapy for schizophrenia

2005 • 315 citations

A double-blind comparison of valproate and lithium in the treatment of acute mania

1992 • 312 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1969 • 303 citations

Update on the Clinical Efficacy and Side Effects of Clozapine

1991 • 298 citations

Psychopharmacologic Treatment of Schizophrenia

1993 • 283 citations

An overview of the mechanism of action of clozapine.

1994 • 283 citations

Risperidone Versus Clozapine in Treatment-Resistant Chronic Schizophrenia: A Randomized Double-Blind Study

1998 • 277 citations

Schizophrenia

1996 • 270 citations

Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia

1989 • 261 citations

Sulpiride augmentation in people with schizophrenia partially responsive to clozapine

1997 • 261 citations

Positive and Negative Symptom Response to Clozapine in Schizophrenic Patients With and Without the Deficit Syndrome

1998 • 258 citations

Compliance with antipsychotic drug treatment: influence of side effects

1994 • 249 citations

At Issue: Defining Treatment Refractoriness in Schizophrenia

1990 • 248 citations

Olanzapine Compared With Chlorpromazine in Treatment-Resistant Schizophrenia

1998 • 239 citations

Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients

1995 • 207 citations

Principles and Practice of Psychopharmacotherapy

1993 • 188 citations

A Controlled Dose Comparison of Haloperidol in Newly Admitted Schizophrenic Patients

1990 • 187 citations

Conventional Antipsychotic Medications for Schizophrenia

1995 • 185 citations

A comparison of the effects of quetiapine (‘Seroquel’) and haloperidol in schizophrenic patients with a history of and a demonstrated, partial response to conventional antipsychotic treatment

2000 • 180 citations

When Symptoms Persist: Choosing Among Alternative Somatic Treatments for Schizophrenia

1991 • 179 citations

A Double-Blind Comparative Study of Clozapine and Risperidone in the Management of Severe Chronic Schizophrenia

2001 • 174 citations

Fluphenazine Decanoate, Fluphenazine Hydrochloride Given Orally, and Placebo in Remitted Schizophrenics

1977 • 173 citations

Clinical overview of serotonin reuptake inhibitors.

1990 • 166 citations

Patient response and resource management: another view of clozapine treatment of schizophrenia

1995 • 166 citations

Clozapine in tardive dyskinesia: observations from human and animal model studies.

1994 • 158 citations

Risperidone in Treatment-Refractory Schizophrenia

1999 • 149 citations

Antipsychotic Polypharmacy, Part 1: Therapeutic Option or Dirty Little Secret?

1999 • 147 citations

High Dose Chlorpromazine Therapy in Chronic Schizophrenia

1968 • 147 citations

Effect of Risperidone on Hostility in Schizophrenia

1995 • 138 citations

Risperidone as an adjunct to clozapine therapy in chronic schizophrenics.

1996 • 138 citations

Prolonged recovery in first-episode psychosis

1998 • 134 citations

A placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients

1975 • 131 citations

Clozapine in tardive dyskinesia

1978 • 131 citations

Treatment of neuroleptic-resistant schizophrenic relapse.

1993 • 127 citations

Comparative efficacy of olanzapine and haloperidol for patients with treatment-resistant schizophrenia∗∗See accompanying Editorial, in this issue.

1999 • 126 citations

Treatment-resistant schizophrenic patients respond to clozapine after olanzapine non-response

1999 • 123 citations

Randomized, Double-Blind, Controlled Trial of Risperidone Versus Clozapine in Patients With Chronic Schizophrenia

1995 • 122 citations

Antipsychotic Drugs

1977 • 121 citations

Interstitial cells of the white matter in the inferior parietal cortex in schizophrenia: An unbiased cell-counting study

1999 • 118 citations

Cost-Effectiveness of Clozapine for Treatment-Resistant Schizophrenic Patients

1990 • 116 citations

Time to clozapine response in a standardized trial

1997 • 108 citations

Clozapine Eligibility Among State Hospital Patients

1996 • 107 citations

Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders.

1995 • 104 citations

Changes in Use of Valproate and Other Mood Stabilizers for Patients With Schizophrenia From 1994 to 1998

2000 • 104 citations

Combined Electroconvulsive-Clozapine Therapy

2000 • 104 citations

Efficacy and safety of risperidone in the long-term treatment of patients with schizophrenia

1995 • 104 citations

Clozapine Treatment of Outpatients With Schizophrenia: Outcome and Long-Term Response Patterns

2000 • 103 citations

Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug

1993 • 103 citations

Randomized, Placebo-Controlled Pilot Study of Divalproex Sodium in the Treatment of Acute Exacerbations of Chronic Schizophrenia

2000 • 98 citations

ICI 204,636, a novel, atypical antipsychotic: early indication of safety and efficacy in patients with chronic and subchronic schizophrenia

1995 • 92 citations

The Expert Consensus Guidelines for treating depression in bipolar disorder.

1998 • 91 citations

Prediction of outcome in first-episode schizophrenia.

1993 • 88 citations

Cost-effectiveness of Clozapine in Patients With High and Low Levels of Hospital Use

1999 • 86 citations

The effects of clozapine on severely aggressive psychiatric inpatients in a state hospital.

1993 • 85 citations

Lithium combined with neuroleptics in chronic schizophrenic and schizoaffective patients.

1981 • 83 citations

Lithium in Chronic Schizophrenia

1979 • 78 citations

Refractory schizophrenia and atypical antipsychotics

2000 • 78 citations

New Drugs for the Treatment of Schizophrenia

1993 • 78 citations

Combined electroconvulsive therapy and clozapine in treatment -resistant schizophrenia

1999 • 78 citations

Use of Antipsychosis and Adjunctive Medications by an Inner Urban Community Psychiatric Service

1999 • 77 citations

Aggressive Behaviors among the Institutionalized Elderly

1993 • 76 citations

Risperidone versus clozapine in treatment-resistant schizophrenia: A randomized pilot study

2000 • 73 citations

Clinical Review of Clozapine Treatment in a State Hospital

1992 • 73 citations

Olanzapine in Treatment-Refractory Schizophrenia

1997 • 72 citations

Pimozide augmentation for the treatment of schizophrenic patients who are partial responders to clozapine

1997 • 72 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1969 • 70 citations

Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

1986 • 70 citations

How Long to Wait for a Response to Clozapine: A Comparison of Time Course of Response to Clozapine and Conventional Antipsychotic Medication in Refractory Schizophrenia

1999 • 68 citations

Risperidone Augmentation of Clozapine

1995 • 67 citations

Olanzapine Augmentation of Clozapine

1998 • 67 citations

Optimal Dosing With Risperidone

2001 • 67 citations

Clozapine Augmentation: Safety and Efficacy

2000 • 67 citations

Effects of stringent criteria on eligibility for clozapine among public mental health clients

1995 • 66 citations

Risperidone and clozapine combination for the treatment of refractory schizophrenia

1999 • 65 citations

Clozapine and risperidone: combination/ augmentation treatment of refractory schizophrenia: a preliminary observation

2000 • 65 citations

High Potency Neuroleptics and Violence in Schizophrenics

1988 • 65 citations

Olanzapine augmentation of clozapine.

1998 • 62 citations

Review of recent clinical studies with olanzapine

1999 • 61 citations

Adjunctive Loxapine in a Clozapine-Resistant Cohort of Schizophrenic Patients

1996 • 60 citations

Commentary: Defining Treatment Refractoriness in Schizophrenia

1990 • 58 citations

Cerebral morphometry and clozapine treatment in schizophrenia.

1994 • 57 citations

Clozapine and risperidone: combination/ augmentation treatment of refractory schizophrenia: a preliminary observation

2000 • 52 citations

Restraint, seclusion, and clozapine.

1992 • 52 citations

An Open Comparison of Clozapine and Risperidone in Treatment-Resistant Schizophrenia

1998 • 51 citations

Combined Treatment of Schizophrenic Psychoses with Haloperidol and Valproate

1998 • 51 citations

The effectiveness of olanzapine in treatment-refractory schizophrenia when patients are nonresponsive to or unable to tolerate clozapine

2000 • 51 citations

Concurrent Administration of Clozapine and ECT

1998 • 51 citations

Neuroleptic-resistant schizophrenia treated with clozapine and ECT.

1996 • 50 citations

Combined use of Risperidone and Olanzapine in the Treatment of Patients with Resistant Schizophrenia[colon] A Preliminary Case Series Report

2000 • 50 citations

NIMH Activities: Clinical Implications of Clozapine Discontinuation: Report of an NIMH Workshop

1995 • 50 citations

Poor neuroleptic response in acutely exacerbated schizophrenic patients

1993 • 49 citations

Change in Haloperidol Level Due to Carbamazepine???A Complicating Factor in Combined Medication for Schizophrenia

1990 • 47 citations

Thioridazine and chlordiazepoxide, alone and combined, in the treatment of chronic schizophrenia

1968 • 46 citations

Schizophrenia: Improving Outcome

1999 • 46 citations

The combined use of neuroleptics and ECT in drug resistant schizophrenic patients.

1986 • 46 citations

Pharmacoepidemiology of Clozapine in 202 Inpatients with Schizophrenia

1993 • 45 citations

Benzodiazepine augmentation of neuroleptics in treatment-resistant schizophrenia.

1992 • 44 citations

Risperidone and clozapine in the treatment of drug-resistant schizophrenia and neuroleptic-induced supersensitivity psychosis

1994 • 43 citations

Myoclonus in patients treated with clozapine: a case series.

1995 • 43 citations

The use of carbamazepine in the treatment of schizophrenic and schizoaffective psychoses: a review.

1992 • 40 citations

Olanzapine for Patients with Treatment-Resistant Schizophrenia: A Naturalistic Case-Series Outcome Study

1999 • 40 citations

Antipsychotic drugs and relapse prevention

1999 • 39 citations

Predictors of Response to Neuroleptic Treatment in Schizophrenia

1993 • 38 citations

Comparative effects of fluphenazine, fluphenazine-chlordiazepoxide and fluphenazine-imipramine.

1970 • 37 citations

Maintenance ECT in treatment-resistant schizophrenia.

2000 • 37 citations

Olanzapine and Sulpiride: A Preliminary Study of Combination/Augmentation in Patients With Treatment-Resistant Schizophrenia

2000 • 36 citations

Lithium-Neuroleptic Neurotoxicity Is Dose Dependent

1987 • 36 citations

Olanzapine for Schizophrenia Refractory to Typical and Atypical Antipsychotics: An Open-Label, Prospective Trial

2001 • 36 citations

Lithium Augmentation Fails to Reduce Symptoms in Poorly Responsive Schizophrenic Outpatients

1999 • 35 citations

Pharmacological treatment strategies in the non-responsive schizophrenic patient

1996 • 34 citations

Treatment resistant chronic psychopathology and CT scans in schizophrenia

1987 • 32 citations

A Dose-Outcome Analysis of Risperidone

1999 • 32 citations

Non-lithium treatment for bipolar disorder.

1990 • 31 citations

An Open Trial of Olanzapine in Patients With Treatment-Refractory Psychoses

1999 • 30 citations

Case report of a possible interaction between neuroleptics and carbamazepine

1984 • 30 citations

Neuroleptics and Reserpine in Refractory Psychoses

1986 • 30 citations

Clinical and Psychopharmacologic Factors Influencing Family Burden in Refractory Schizophrenia

2000 • 30 citations

Plasma Homovanillic Acid as an Index of Central Dopaminergic Activity: Studies in Schizophrenic Patients

1988 • 29 citations

The Evolution of Treatment Resistance: Biologic Implications

1998 • 29 citations

Clinical review of clozapine treatment in a state hospital

1993 • 27 citations

QUETIAPINE FOR REFRACTORY SCHIZOPHRENIA

1998 • 25 citations

Benzodiazepine augmentation of neuroleptic treatment in patients with schizophrenia.

1989 • 24 citations

Augmentation with sulpiride for a schizophrenic patient partially responsiveto clozapine

2000 • 22 citations

Are Biochemical Markers for Treatment-Resistant Schizophrenia State Dependent or Traits?

1990 • 21 citations

Efficacy of Electroconvulsive Therapy in Schizophrenia, Mania, and Other Disorders. I. Schizophrenia.

1985 • 21 citations

Clozapine: Current Status and Role in the Pharmacotherapy of Schizophrenia

1996 • 20 citations

STANDARDS OF CARE AND CLINICAL ALGORITHMS FOR TREATING SCHIZOPHRENIA

1998 • 19 citations

Estimating Clozapine's Cost to the Nation

1990 • 19 citations

Management of treatment-resistant schizophrenia with olanzapine.

1998 • 15 citations

Efficacy of β-blocker supplementation for schizophrenia: a systematic review of randomized trials

2000 • 13 citations

Catching up on Schizophrenia

1996 • 10 citations

Effect of adjuvant reserpine treatment on catecholamine metabolism in schizophrenic patients under long-term neuroleptic treatment

1988 • 6 citations

[Seroquel in a resistant schizophrenic with negative and positive symptoms].

1996 • 6 citations

[Reconsideration of reserpine in the treatment of schizophrenia].

1968 • 1 citations

[Very high reserpine dosage in the treatment of chronic schizophrenia].

1967 • 1 citations

Deleted Work

1955 • 0 citations