Cell Migration in the Immune System: the Evolving Inter-Related Roles of Adhesion Molecules and Proteinases

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation

1992 • 1,255 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Rapid neutrophil adhesion to activated endothelium mediated by GMP-140

1990 • 997 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

1989 • 837 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.

1992 • 737 citations

A tissue-specific endothelial cell molecule involved in lymphocyte homing

1988 • 725 citations

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

1991 • 719 citations

Downregulation of Fas ligand by shedding

1998 • 681 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

Matrix metalloproteinases in immunity.

1996 • 554 citations

Simulation of cell rolling and adhesion on surfaces in shear flow: general results and analysis of selectin-mediated neutrophil adhesion

1992 • 540 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

1987 • 417 citations

Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.

1989 • 413 citations

EndoCAM: a novel endothelial cell-cell adhesion molecule.

1990 • 409 citations

Neutrophils roll on E-selectin.

1993 • 339 citations

Lymphocyte interactions with extracellular matrix

1991 • 336 citations

Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

1996 • 331 citations

The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.

1991 • 307 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

Transient adhesion of neutrophils to endothelium.

1989 • 279 citations

TIMP-2 Promotes Activation of Progelatinase A by Membrane-type 1 Matrix Metalloproteinase Immobilized on Agarose Beads

1998 • 276 citations

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.

1994 • 250 citations

Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells.

1983 • 245 citations

Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules.

1990 • 241 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.

1990 • 224 citations

The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts.

1994 • 222 citations

Metalloproteinase-mediated Regulation of L-selectin Levels on Leucocytes

1996 • 212 citations

SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines.

1998 • 202 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo

1997 • 184 citations

Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8.

1985 • 180 citations

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS

1998 • 179 citations

Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.

1984 • 178 citations

Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.

1996 • 173 citations

P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities.

1992 • 160 citations

Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.

1991 • 154 citations

Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 • 152 citations

Relevance of L-selectin Shedding for Leukocyte Rolling In Vivo

1999 • 149 citations

Stimulation of matrix metalloproteinase‐dependent migration of T cells by eicosanoids

1995 • 128 citations

Proteases Associated with Invadopodia, and Their Role in Degradation of Extracellular Matrix

1996 • 123 citations

Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin‐1

1995 • 119 citations

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid

1998 • 109 citations

Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes: functional consequences for neutrophil aggregation.

1996 • 106 citations

Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation.

1997 • 103 citations

Human lymphoblastoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, and angiogenesis

1998 • 98 citations

Cell surface lectins in the immune system

1993 • 97 citations

Matrix Metalloproteinase MMP-19 (RASI-1) is Expressed on the Surface of Activated Peripheral Blood Mononuclear Cells and is Detected as an Autoantigen in Rheumatoid Arthritis

1998 • 91 citations

The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration

1996 • 89 citations

Production and regulation of gelatinase B by human T-cells

1993 • 80 citations

Expression of the CD34 gene in vascular endothelial cells

1990 • 76 citations

Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation.

1992 • 74 citations

Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration

1995 • 69 citations

Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform.

1995 • 68 citations

Collagen induced MMP-2 activation in human breast cancer

1994 • 60 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 24 citations

Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane

1996 • 23 citations

Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Reactive and Neoplastic Lymphoid Cells

1997 • 21 citations

Global vascular expression of murine CD34, a sialomucin-like endothelial ligand for L-selectin

1994 • 17 citations

Signals on endothelium for lymphocyte recirculation and leukocyte emigration: the area code paradigm.

1993 • 15 citations

Fibronectin expression correlates with U937 cell adhesion to migrating bovine aortic endothelial cells in vitro.

1993 • 12 citations

Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro

1991 • 6 citations

[Integrins and metalloproteinases: an efficient collaboration in the invasive process].

1999 • 4 citations