Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontin

CELL SURFACE INTERACTIONS WITH EXTRACELLULAR MATERIALS

1983 • 1,147 citations

Osteopontin: a protein with diverse functions

1993 • 1,082 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

1996 • 930 citations

Osteopontin--a possible anchor of osteoclasts to bone.

1990 • 816 citations

Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens

1984 • 655 citations

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

1993 • 537 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

1994 • 377 citations

Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone.

1987 • 373 citations

Vitronectin—A major cell attachment-promoting protein in fetal bovine serum

1985 • 339 citations

CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.

1999 • 321 citations

Tumour promoter induces anchorage independence irreversibly

1979 • 285 citations

Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by α9β1 Integrin

1996 • 246 citations

A Biochemical Characterization of the Binding of Osteopontin to Integrins αvβ1 and αvβ5

1995 • 245 citations

Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells.

1978 • 243 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

Osteopontin is a ligand for the α4β1 integrin

1998 • 214 citations

Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene.

1993 • 207 citations

Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.

1989 • 205 citations

Osteopontin Expression in Cardiovascular Diseases^a

1995 • 187 citations

Integrin‐mediated attachment of articular chondrocytes to extracellular matrix proteins

1993 • 187 citations

Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice

1999 • 175 citations

Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit.

1987 • 137 citations

Molecular cloning of a tumor promoter‐inducible mRNA found in JB6 mouse epidermal cells: Induction is stable at high, but not at low, cell densities

1987 • 132 citations

Secreted phosphoprotein mrna is induced during multi‐stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts

1990 • 118 citations

A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells

1983 • 113 citations

Site‐directed mutagenesis of the arginine‐glycine‐aspartic acid sequence in osteopontin destroys cell adhesion and migration functions

1995 • 105 citations

Osteopontin expression in mammary gland development and tumorigenesis.

1997 • 93 citations

Evidence that a non-RGD domain in rat osteopontin is involved in cell attachment

1993 • 83 citations

Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments.

1992 • 83 citations

Secondary Structure Predictions for Rat Osteopontin

1989 • 68 citations

Kinetic and morphological evidence for endocytosis of mammalian cell integrin receptors by using an anti-fibronectin receptor β subunit monoclonal antibody

1989 • 54 citations

Adhesion Properties and Integrin Expression of Cultured Human Osteoclast-like Cells

1994 • 52 citations

Adhesion of metastatic, ras-transformed NIH 3T3 cells to osteopontin, fibronectin, and laminin.

1993 • 52 citations

1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated osteopontin (secreted phosphoprotein 1) in mouse JB6 epidermal cells.

1991 • 51 citations

Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins

1996 • 50 citations

Expression of wild-type and mutated rabbit osteopontin in Escherichia coli, and their effects on adhesion and migration of P388D1 cells

1995 • 49 citations

Role of cytoskeleton changes and expression of the H-ras oncogene during promotion of neoplastic transformation in mouse epidermal JB6 cells.

1986 • 40 citations

1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells.

1993 • 33 citations

Quantitative measurement of α6β1 and α6β4 integrin internalization under cross-linking conditions: a possible role for α6 cytoplasmic domains

1994 • 28 citations

Evidence for two pathways of protein kinase C induction of 2AR expression: Correlation with mitogenesis

1989 • 23 citations

Adhesion of Human Myelomonocytic (HL-60) Cells Induced by 1, 25-dihydroxyvitamin D₃and Phorbol Myristate Acetate is Dependent on Osteopontin Synthesis and the α_vβ₃Integrin

1996 • 22 citations

Osteopontin: Potential roles in vascular function and dystrophic calcification

1997 • 22 citations

Osteopontin adhesion receptors on gingival fibroblasts

1995 • 16 citations

Release of fibronectin is linked to tumor promotion: response of promotable and non-promotable clones of a mouse epidermal cell line

1985 • 15 citations

Transfer by pro gene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells.

1988 • 14 citations

Four-day duration of tumor promoter exposure required to transform JB6 promotion-sensitive cells to anchorage independence.

1988 • 14 citations