Intracellular P-glycoprotein expression is associated with the intrinsic multidrug resistance phenotype in human colon adenocarcinoma cells

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

The drug resistance-related protein LRP is the human major vault protein

1995 • 621 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

1995 • 501 citations

Biology of the multidrug resistance-associated protein, MRP

1996 • 367 citations

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.

1994 • 284 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

1992 • 166 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Unlocking vaults: organelles in search of a function

1991 • 128 citations

Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin

1986 • 119 citations

Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction.

1990 • 111 citations

Major vault protein LRP-related multidrug resistance

1996 • 99 citations

Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells.

1992 • 94 citations

P‐glycoprotein expression in the Golgi apparatus of multidrug‐resistant cells

1994 • 81 citations

Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution.

1995 • 74 citations

Vimentin is preferentially expressed in high-grade ductal and medullary, but not in lobular breast carcinomas.

1990 • 71 citations

Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines

1997 • 70 citations

P‐glycoprotein epitope mapping. I. Identification of a linear human‐specific epitope in the fourth loop of the P‐glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multi‐drug‐resistant cells

1994 • 69 citations

Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells

1998 • 67 citations

Using purified P-glycoprotein to understand multidrug resistance

1995 • 67 citations

Functional intracellular P‐glycoprotein

1998 • 65 citations

Functional intracellular P-glycoprotein

1998 • 62 citations

In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells.

1991 • 52 citations

Intracellular localization of the antitumour drug adriamycin in living cultured cells: A confocal microscopy study

1994 • 49 citations

CANCER BIOLOGY: The antitumor drug fostriecin induces vimentin hyperphosphorylation and intermediate filament reorganization

1996 • 39 citations

Ultrastructural localization of daunomycin in multidrug-resistant cultured cells with modulation of the multidrug transporter.

1993 • 35 citations

Intracellular distribution of anthracyclines in drug resistant cells.

1998 • 35 citations

Co-expression of MDR-associated markers, including P-170, MRP and LRP and cytoskeletal proteins, in three resistant variants of the human ovarian carcinoma cell line, OAW42

1997 • 33 citations

Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin

1997 • 30 citations

Inhibition of protein kinase C-α isoform enhances the P-glycoprotein expression and the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposure

1998 • 22 citations

Taxol induces concomitant hyperphosphorylation and reorganization of vimentin intermediate filaments in 9l rat brain tumor cells

1998 • 20 citations

Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin

1995 • 19 citations

Analysis of calcium-dependent protein kinase-C isoenzymes in intrinsically resistant cloned lines of LoVo cells: reversal of resistance by kinase inhibitor 1-(5-isoquinolinylsulfonyl) 2-methylpiperazine.

1993 • 14 citations