Alterations of p16-pRb Pathway and Chromosome Locus 9p21–22 in Sporadic Invasive Breast Carcinomas

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Histological Grading and Prognosis in Breast Cancer

1957 • 2,897 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Cancer statistics, 1994

1994 • 1,345 citations

Basic methods in molecular biology

1987 • 842 citations

Antioncogenes and human cancer.

1993 • 772 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

1996 • 404 citations

Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

1994 • 370 citations

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

1994 • 237 citations

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

1994 • 231 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

1995 • 215 citations

Somatic genetic changes in human breast cancer

1994 • 214 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

Microsatellite instability and loss of heterozygosity in breast cancer.

1994 • 189 citations

Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

1997 • 150 citations

Splicing into Senescence: The Curious Case of p16 and p19ARF

1997 • 148 citations

Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer.

1996 • 134 citations

High frequency of aberrant p16(INK4A) expression in human breast cancer.

1996 • 134 citations

Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies

1996 • 129 citations

Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study

1996 • 128 citations

Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group.

1993 • 128 citations

Increased p16 levels correlate with pRb alterations in human urothelial cells.

1995 • 120 citations

Microsatellite instability and other molecular abnormalities in non-small cell lung cancer

1995 • 117 citations

The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

1992 • 113 citations

Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and histopathological parameters

1998 • 112 citations

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.

1994 • 107 citations

Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21–22 in Non-Small-Cell Lung Carcinomas

1998 • 105 citations

Down regulation of talin alters cell adhesion and the processing of the α5β1 integrin

1995 • 105 citations

Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells.

1995 • 95 citations

Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor gene.

1997 • 92 citations

Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

1995 • 90 citations

Colon cancer and DNA repair: have mismatches met their match?

1994 • 90 citations

Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level.

1991 • 88 citations

Frequent p53 gene mutations and novel alleles in familial breast cancer.

1994 • 83 citations

Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity.

1996 • 80 citations

CYCLIN D1 AND RETINOBLASTOMA GENE EXPRESSION IN HUMAN BREAST CARCINOMA: CORRELATION WITH TUMOUR PROLIFERATION AND OESTROGEN RECEPTOR STATUS

1997 • 78 citations

Polymerase chain reaction microanalysis of tumors from stained histological slides.

1992 • 73 citations

Cyclin-d1-gene amplification and expression in breast carcinoma: Relation with clinicopathologic characteristics and with retinoblastoma gene product, p53 and p21waf1 immunohistochemical expression

1997 • 73 citations

Expression of the cyclin‐dependent kinase inhibitors p16^INK4, p15^INK4B and p21Waf1/cip1 in human breast cancer

1995 • 71 citations

Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer: An immunohistochemical study

1992 • 67 citations

Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti‐RB antibodies

1994 • 66 citations

Microsatellite instability in early sporadic breast cancer

1996 • 66 citations

Microsatellite instabilities at five chromosomes in primary breast tumors.

1994 • 60 citations

Retinoblastoma and p53 gene product expression in breast carcinoma: Immunohistochemical analysis and clinicopathologic correlation

1992 • 59 citations

Alterations of CDKN2 (p16) in non‐small cell lung cancer

1995 • 52 citations

E2F: a nodal point in cell cycle regulation

1997 • 48 citations

Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue

1998 • 47 citations

A MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF THE MDM2 PROTEIN ISOFORMS ANDp53 GENE PRODUCT IN BRONCHOGENIC CARCINOMA

1996 • 45 citations

Staging and follow-up of breast cancer patients

1991 • 44 citations

Frequent p16INK4 (MTS1) gene inactivation in testicular germ cell tumors.

1997 • 40 citations

Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry

1998 • 39 citations

Loss of heterozygosity at 9p23 defines a novel locus in non-small cell lung cancer

1995 • 36 citations

Analysis of p16 gene deletion and point mutation in breast carcinoma

1995 • 34 citations

Differential expression of the cyclin-dependent kinase inhibitors p16 and p21 in the human melanocytic system.

1996 • 33 citations

Infrequent CDKN2 (MTS1/p16) gene alterations in human primary breast cancer

1995 • 33 citations

Association between rb‐1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival

1995 • 31 citations

RETINOBLASTOMA PROTEIN IN HUMAN BREAST CARCINOMA: IMMUNOHISTOCHEMICAL STUDY USING A NEW MONOCLONAL ANTIBODY EFFECTIVE ON ROUTINELY PROCESSED TISSUES

1996 • 28 citations

Molecular analysis of p53 gene in laryngeal premalignant and malignant lesions. p53 protein immunohistochemical expression is positively related to proliferating cell nuclear antigen labelling index

1995 • 23 citations

Loss of heterozygosity at selective sites on chromosomes 13 and 17 in human breast carcinoma.

1991 • 21 citations

Immunohistochemical and molecular evaluation of the mdm-2 gene product in bronchogenic carcinoma

1996 • 20 citations

Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast

1998 • 15 citations

Analysis of MTS1/CDK4 in female breast carcinomas

1995 • 13 citations

Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p

1995 • 11 citations

Expression of p16 and Cyclin-Dependent Kinase 4 Proteins in Primary Breast Carcinomas

1997 • 8 citations

Currently Active Protocols in the EORTC Breast Cancer Cooperative Group

1984 • 1 citations

Deleted Work

1955 • 0 citations