Alterations of methylation of the tumor suppressor gene p53: insights into potential mechanisms of arsenic carcinogenesis

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Casarett and Doull's toxicology

2015 • 1,127 citations

Cancer risks from arsenic in drinking water.

1992 • 1,069 citations

Prevalence of Skin Cancer in an Endemic Area of Chronic Arsenicism in Taiwan<xref ref-type="fn" rid="FN2">2</xref>

1968 • 804 citations

Effects of DNA methylation on DNA-binding proteins and gene expression

1993 • 732 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Arsenic in the environment part II: Human health and ecosystem effects

1995 • 392 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

1997 • 306 citations

Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens.

1995 • 245 citations

Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells.

1995 • 214 citations

Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rabbits

1983 • 205 citations

Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man

1985 • 205 citations

Cancers related to exposure to arsenic at a copper smelter.

1995 • 153 citations

Arsenic induces and enhances rat hepatic metallothionein production in vivo

1992 • 82 citations

Alterations in DNA helix stability due to base modifications can be evaluated using denaturing gradient gel electrophoresis

1987 • 64 citations

Implications of Arsenic Genotoxicity for Dose Response of Carcinogenic Effects

1996 • 54 citations

Heat shock gene expression in Xenopus laevis A6 cells in response to heat shock and sodium arsenite treatments

1988 • 44 citations

Human carcinogenesis by arsenic

1992 • 35 citations

Micronuclei induced by modulators of methylation: analogs of 5-azacytidine

1995 • 30 citations

Heme oxygenase: Expression in human retina and modulation by stress agents in a human retinoblastoma cell model system

1992 • 26 citations

Progressive Alterations of Cytokeratin Expressions in the Process of Chronic Arsenism

1993 • 21 citations

A nuclear protein that binds preferentially to methylated DNA in vitro may play a role in the inaccessibility of methylated CpGs in mammalian nuclei

1990 • 17 citations

Sister chromatid exchanges induced by DNA demethylating agents persist through several cell cycles in mammalian cells

1987 • 16 citations