Immunohistochemical Demonstration of 15-Lipoxygenase in Transplant Coronary Artery Disease

Beyond Cholesterol

1989 • 6,533 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone.

1987 • 549 citations

Antihemophilic Factor Antigen. LOCALIZATION IN ENDOTHELIAL CELLS BY IMMUNOFLUORESCENT MICROSCOPY

1973 • 449 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.

1991 • 325 citations

Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection

1989 • 324 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

The spectrum of coronary artery pathologic findings in human cardiac allografts.

1989 • 283 citations

Role of oxidised low density lipoprotein in atherogenesis

1993 • 230 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts.

1991 • 219 citations

Cardiac allograft vasculopathy: current concepts, recent developments, and future directions.

1992 • 217 citations

The Registry of the International Society for Heart and Lung Transplantation: tenth official report--1993.

1993 • 210 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Oxygenation of lipoproteins by mammalian lipoxygenases

1993 • 163 citations

Hypercholesterolemia in long-term survivors of heart transplantation: an early marker of accelerated coronary artery disease.

1991 • 141 citations

Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis.

1989 • 139 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.

1991 • 122 citations

Humoral immune responses after cardiac transplantation: correlation with fatal rejection and graft atherosclerosis.

1989 • 110 citations

Posttransplant obesity and hyperlipidemia: major predictors of severity of coronary arteriopathy in failed human heart allografts.

1990 • 109 citations

Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation?

1993 • 101 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Hyperlipidemia after heart transplantation.

1988 • 96 citations

Morphology of solid organ allograft arteriopathy: identification of proliferating intimal cell populations.

1989 • 95 citations

Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.

1990 • 94 citations

Pathologic findings in long-term cardiac transplants.

1984 • 82 citations

Lipoprotein(a) and accelerated coronary artery disease in cardiac transplant recipients

1992 • 79 citations

Arachidonate 15-lipoxygenase; characteristics and potential biological significance.

1991 • 72 citations

Coronary sinus sampling of cytokines after heart transplantation: Evidence for macrophage activation and interleukin-4 production within the graft

1993 • 62 citations

Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.

1994 • 55 citations

Lipid peroxides and antioxidant defenses in accelerated transplantation-associated coronary arteriosclerosis

1993 • 47 citations

Chronic rejection in human heart transplantation.

1988 • 36 citations

Regulation of human aortic endothelial cell-derived mesenchymal growth factors by allogeneic lymphocytes in vitro. A potential mechanism for cardiac allograft vasculopathy.

1993 • 29 citations

Pathology of chronic cardiac rejection: An analysis of the epicardial and intramyocardial coronary arteries and myocardial alterations in 43 human allografts

1993 • 12 citations