Significant frequency of cytotoxic T lymphocyte precursor cells specific for TNP-modified allogeneic cells in normal lymphocytes

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes

1974 • 572 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Fine specificity of a continuously growing killer cell clone specific for H-Y antigen

1979 • 317 citations

Alloreactivity of an antigen-specific T-cell clone

1980 • 150 citations

The Efficient Design of Transplantable Tumour Assays

1963 • 147 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.

1981 • 128 citations

In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.

1978 • 108 citations

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.

1982 • 95 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

1977 • 78 citations

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.

1982 • 58 citations

Analysis of true anti-hapten cytotoxic clones in limit dilution microcultures after correction for "anti-self" activity: precursor frequencies, Ly-2 and Thy-1 phenotype, specificity, and statistical methods.

1983 • 47 citations

T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.

1978 • 42 citations

Selection of the T cell repertoire during ontogeny: Limiting dilution analysis

1982 • 39 citations

Activation of nonspecific killer cells by interleukin 2-containing supernatants.

1983 • 37 citations

Quantitative studies on the precursors of cytotoxic lymphocytes. V. The cellular basis for the cross-reactivity of TNP-specific clones.

1978 • 31 citations

H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.

1981 • 31 citations

T cell‐mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells

1980 • 31 citations

Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.

1981 • 29 citations

Immunology of fully H-2 incompatible bone marrow chimeras induced in specific-pathogen-free mice: evidence for generation of donor- and host-H-2 restricted helper and cytotoxic T cells.

1981 • 28 citations

Rapid changes in specificity within single clones of cytolytic effector cells

1985 • 27 citations

Generation of autoreactive cytotoxic T lymphocytes under limiting dilution conditions.

1983 • 23 citations

Quantitative Studies on the Precursors of Cytotoxic Lymphocytes

1978 • 19 citations

The analysis of an anti‐fluorescein cytotoxic response

1983 • 17 citations

Alloreactive cytotoxic T cells. I. Alloreactive and allorestricted cytotoxic T cells

1985 • 15 citations

H-2 restriction specificity of T cells from H-2 incompatible radiation bone marrow chimeras: Further evidence for the absence of crucial influence of the host/thymus environment on the generation of H-2 restricted TNP-specific T lymphocyte precursors

1984 • 13 citations

Allorestricted cytotoxic T cells. Large numbers of allo-H-2Kb-restricted antihapten and antiviral cytotoxic T cell populations clonally develop in vitro from murine splenic precursor T cells.

1985 • 12 citations