Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes

1974 • 572 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation?

1980 • 269 citations

Cytotoxic T cells learn specificity for self H–2 during differentiation in the thymus

1978 • 219 citations

Expression of MHC Antigens by Mouse Thymic Dendritic Cells

1979 • 191 citations

IA antigens and antigen-presenting function of thymic macrophages.

1980 • 141 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

1978 • 134 citations

Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells.

1979 • 128 citations

Biochemical Relationship of Thymocyte Mitogenic Factor and Factors Enhancing Humoral and Cell-Mediated Immune Responses

1978 • 125 citations

Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.

1977 • 118 citations

The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens

1978 • 101 citations

Role of the Murine Major Histocompatibility Complex in the Specificity of in vitro T‐Cell‐Mediated Lympholysis Against Chemically‐Modified Autologous Lymphocytes

1976 • 97 citations

Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.

1976 • 93 citations

Thymic Regeneration after Lethal Irradiation: Evidence for an Intra-Thymic Radioresistant T Cell Precursor

1975 • 92 citations

The differentiation of cytotoxic T cells in vitro. I. Amplifying factor(s) in the primary response is Lyt 1 + cell dependent.

1979 • 92 citations

T-T cell interactions during in vitro cytotoxic T lymphocyte (CTL) responses. II. Helper factor from activated Lyt 1+ T cells is rate limiting i) in T cell responses to nonimmunogenic alloantigen, ii) in thymocyte responses to allogeneic stimulator cells, and III) recruits allo- or H-2-restricted CTL precursors from the Lyt 123+ T subset.

1980 • 88 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

1977 • 78 citations

Effects of Costimulator on Immune Responses in Vitro

1978 • 75 citations

H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.

1976 • 73 citations

Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells

1976 • 69 citations

Cellular and genetic control of antibody responses in vitro 1.cellular requirements for the generation of genetically controlled primary IgM responses to soluble antigens

1977 • 63 citations

Distinct Effects of Thymic Epithelial Culture Supernatants on T Cell Properties of Mouse Thymocytes Separated by the Use of Peanut Agglutinin

1979 • 56 citations

Distinct effects of T cell growth factors and thymic epithelial factors on the generation of cytotoxic T lymphocytes by thymocyte subpopulations.

1980 • 49 citations

Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.

1979 • 39 citations

T-cell-derived helper factor allows Lyt 123 thymocytes to differentiate into cytotoxic T lymphocytes

1979 • 39 citations

H-2-linked genetic control of murine T-cell-mediated lympholysis to autologous cells modified with low concentrations of trinitrobenzene sulfonate.

1979 • 38 citations

Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

1978 • 38 citations

Genetic control of cytolytic t-lymphocyte responses. II. The role of the host genotype in parental leads to F1 radiation chimeras in the control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

1978 • 26 citations

Cytotoxic T cells recognize male antigen and H-2 as distinct entities.

1978 • 25 citations

Search for suppression of T cells specific for the second nonhost H-2 haplotype in F1 leads to P irradiation bone marrow chimeras.

1979 • 19 citations

The major influence on helper T cell cooperative partner cell preferences is exerted by the extrathymic environment.

1980 • 12 citations

Cellular and genetic control of antibody responses. VII. Absence of detectable suppression maintaining the H-2 restricted recognition of F1 leads to parent helper T cells.

1980 • 6 citations