Analysis of promoter and enhancer cell type specificities and the regulation of immunoglobulin gene expression

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.

1981 • 388 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Tissue-specific expression is conferred by a sequence from the 5′ end of the rat albumin gene.

1984 • 202 citations

Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression of rat prolactin and growth hormone genes

1986 • 181 citations

Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells.

1986 • 178 citations

Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytes

1979 • 158 citations

An immunoglobulin promoter displays cell-type specificity independently of the enhancer

1985 • 144 citations

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

1986 • 140 citations

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.

1983 • 121 citations

Synergism between immunoglobulin enhancers and promoters

1986 • 116 citations

During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation

1986 • 105 citations

Mouse heavy chain variable regions: nucleotide sequence of a germ-line V_Hgene segment

1981 • 68 citations

An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development

1982 • 53 citations

The role of enhancers in the regulation of cell-type-specific transcriptional control

1986 • 52 citations

Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences.

1984 • 42 citations

Cell-surface antigens expressed on L-cells transfected with whole DNA from non-expressing and expressing cells

1984 • 38 citations

HYBRID GENES: MOLECULAR APPROACHES TO TISSUE-SPECIFIC GENE REGULATION

1985 • 29 citations

Expression of cloned imunoglobulin genes introduced into mouse L cells

1983 • 24 citations