Transcriptional Profile of Aging in C. elegans

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Biodemographic Trajectories of Longevity

1998 • 1,057 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Signals from the reproductive system regulate the lifespan of C. elegans

1999 • 956 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

LABORATORY EVOLUTION OF POSTPONED SENESCENCE INDROSOPHILA MELANOGASTER

1984 • 774 citations

Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span

1977 • 772 citations

A Gene Expression Map for Caenorhabditis elegans

2001 • 674 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Laboratory Evolution of Postponed Senescence in Drosophila melanogaster

1984 • 641 citations

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

2001 • 637 citations

The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster

2001 • 634 citations

A Global Profile of Germline Gene Expression in C. elegans

2000 • 595 citations

Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster

2002 • 567 citations

SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER

1984 • 562 citations

Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans

2002 • 485 citations

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

1983 • 427 citations

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

2001 • 421 citations

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

2001 • 386 citations

Non-ageing developmental variant of Caenorhabditis elegans

1976 • 373 citations

Genome-wide study of aging and oxidative stress response inDrosophilamelanogaster

2000 • 315 citations

Loss of Transcriptional Silencing Causes Sterility in Old Mother Cells of S. cerevisiae

1996 • 308 citations

Genetic analysis of life-span in Caenorhabditis elegans.

1982 • 302 citations

Genomic Analysis of Gene Expression in C. elegans

2000 • 300 citations

Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans

2000 • 295 citations

Selection for life span in Drosophila melanogaster

1985 • 247 citations

More is not better: brood size and population growth in a self-fertilizing nematode

1991 • 236 citations

Changes in Gene Expression Associated with Developmental Arrest and Longevity in Caenorhabditis elegans

2001 • 219 citations

Production of Age-Synchronous Mass Cultures of Caenorhabditis elegans

1994 • 137 citations

Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters

1981 • 130 citations

Defining Wild-Type Life Span in Caenorhabditis elegans

2000 • 129 citations

Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans

1980 • 101 citations

Programmed aging or error catastrophe? An exmination by two-dimensional polyacrylamide gel electrophoresis

1985 • 66 citations

Specific Alterations in Transcript Prevalence During the Yeast Life Span

1989 • 60 citations

Age-Specific Demographic Profiles of Longevity Mutants in Caenorhabditis elegans Show Segmental Effects

2001 • 57 citations

Increase in Basal Level of Hsp70, Consisting Chiefly of Constitutively Expressed Hsp70 (Hsc70) in Aged Rat Brain

2000 • 40 citations

Identification of Genes That Are DifferentiallyExpressed During Aging in Caenorhabditis elegans

1995 • 30 citations

UV‐A‐related alterations of young and adult lens water‐insoluble α‐crystallin, plasma membranous and cytoskeletal proteins

2001 • 30 citations

Stress Response and Aging in Caenorhabditis elegans

2000 • 30 citations

Molecular Genetic Mechanisms of Life Span Manipulation in Caenorhabditis elegans

2000 • 28 citations

Comparative demography of isogenic populations of Caenorhabditis elegans

2001 • 18 citations

Total RNA, rRNA and poly(A)+ RNA abundances during aging in Caenorhabditis elegans

1995 • 14 citations

More Is Not Better

1987 • 6 citations