Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus)

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels

1976 • 1,060 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

Quantitative determination of cytochrome P-450 in rat liver homogenate

1976 • 362 citations

[22] The measurement of difference spectra: Application to the cytochromes of microsomes

1978 • 294 citations

Nucleotide sequence of the Pseudomonas putida cytochrome P-450cam gene and its expression in Escherichia coli.

1986 • 225 citations

A Spectrophotometric Method for the Simultaneous Determination of Myoglobin and Hemoglobin in Extracts of Human Muscle.

1948 • 221 citations

Isolation and purification of cytochrome P-450, and the existence of multiple forms

1979 • 210 citations

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes.

1984 • 207 citations

Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation.

1980 • 171 citations

Cloning and Expression in Streptomyces lividans of Clustered Erythromycin Biosynthesis Genes from Streptomyces erythreus

1986 • 127 citations

Genetic analysis of erythromycin production in Streptomyces erythreus

1985 • 110 citations

Transfer of the Type Strain of Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 to the Genus Saccharopolyspora Lacey and Goodfellow 1975 as Saccharopolyspora erythraea sp. nov., and Designation of a Neotype Strain for Streptomyces erythraeus

1987 • 104 citations

A prostaglandin omega-hydroxylase cytochrome P-450 (P-450PG-omega) purified from lungs of pregnant rabbits.

1984 • 102 citations

Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation.

1984 • 95 citations

Transformation of Streptomyces erythraeus.

1986 • 91 citations

Isolation, purification, and properties of a unique form of cytochrome P-450 in microsomes of isosafrole-treated rats.

1981 • 85 citations

High-performance liquid chromatographic determination of erythromycin

1978 • 82 citations

[26] Protein chromatography on hydroxyapatite columns

1990 • 81 citations

Multiple, immunoidentical forms of phenobarbital-induced rat liver cytochromes P-450 are encoded by different mRNAs.

1982 • 68 citations

Isolation and characterization of an acyl-coenzyme A carboxylase from an erythromycin-producing Streptomyces erythreus

1982 • 67 citations

Isoenzyme-specific phosphorylation of cytochromes P-450 and other drug metabolizing enzymes

1987 • 51 citations

Phosphorylation of rabbit liver cytochrome P-450 LM2 and its effect on monooxygenase activity

1984 • 47 citations

Conversion of hepatic microsomal cytochrome P-450 to P-420 upon phosphorylation by cyclic AMP dependent protein kinase

1985 • 47 citations

Induction of cytochrome P-450-dependent sulfonylurea metabolism in Streptomyces griseolus

1986 • 45 citations

Metabolic conditions determining the composition and catalytic activity of cytochrome P-450 monooxygenases in Candida tropicalis

1984 • 37 citations

P-450 hemeproteins of Rhizobium japonicum purification by affinity chromatography and relationship to P-450CAM and P-450LM-2

1976 • 34 citations

Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus

1984 • 33 citations

[33] S-adenosylmethionine:Erythromycin C O-methyltransferase

1975 • 31 citations

Malonyl-CoA Decarboxylase from Streptomyces erythreus: Purification, properties, and possible role in the production of erythromycin

1984 • 20 citations

Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at C-6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system

1982 • 19 citations

[³H]Tetrahydrocerulenin, a specific reagent for radio‐labelling fatty acid synthases and related enzymes

1983 • 18 citations