Related Adhesion Focal Tyrosine Kinase and the Epidermal Growth Factor Receptor Mediate the Stimulation of Mitogen-activated Protein Kinase by the G-protein-coupled P2Y2 Receptor

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

1994 • 704 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

1998 • 569 citations

ATP mediates fast synaptic transmission in mammalian neurons

1992 • 549 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

1997 • 286 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Calcium influx induces neurite growth through a Src-Ras signaling cassette

1995 • 261 citations

Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling

1997 • 204 citations

Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C

1998 • 179 citations

Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels.

1996 • 174 citations

Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes

1996 • 167 citations

How should P2x purinoceptors be classified pharmacologically?

1995 • 163 citations

p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells

1996 • 143 citations

Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors

1996 • 117 citations

Mitogenic signaling from the egf receptor is attenuated by a phospholipase C-gamma/protein kinase C feedback mechanism.

1996 • 101 citations

A Role for Src in Signal Relay by the Platelet-derived Growth Factor α Receptor

1998 • 88 citations

Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase

1993 • 76 citations

Neuronal "nucleotide" receptor linked to phospholipase C and phospholipase D? Stimulation of PC12 cells by ATP analogues and UTP.

1992 • 75 citations

Nerve growth factor stimulates the activities of the raf-1 and the mitogen-activated protein kinases via the trk protooncogene.

1992 • 68 citations

ATP-stimulated Activation of the Mitogen-activated Protein Kinases through Ionotrophic P2X2 Purinoreceptors in PC12 Cells

1998 • 67 citations

Extracellular atp triggers two functionally distinct calcium signalling pathways in pc12 cells

1994 • 52 citations

The Epidermal Growth Factor Receptor Associates with and Recruits Phosphatidylinositol 3-Kinase to the Platelet-derived Growth Factor β Receptor

1998 • 50 citations

Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice.

1995 • 40 citations

Cross-talk between Phorbol Ester-mediated Signaling and Tyrosine Kinase Proto-oncogenes

1997 • 39 citations

Extracellular ATP induces formation of AP-1 complexes in astrocytes via P2 purinoceptors

1996 • 36 citations

Silencing of the epidermal growth factor receptor in the absence of the ligand requires phospholipase C activity

1995 • 11 citations