Growth factors and cutaneous wound repair

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Angiogenic Factors

1987 • 3,702 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

Transforming growth factor α

1988 • 707 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Fibronectin and Fibrin Provide a Provisional Matrix for Epidermal Cell Migration During Wound Reepithelialization

1982 • 695 citations

PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

1990 • 689 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.

1989 • 591 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Induction of tenascin in healing wounds.

1988 • 563 citations

Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing.

1988 • 559 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

1991 • 541 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice.

1989 • 451 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

The stimulation of epidermal proliferation by a specific protein (EGF)

1965 • 421 citations

Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors.

1987 • 421 citations

Growth factors are released by mechanically wounded endothelial cells.

1989 • 420 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Immunohistochemical localization of growth factors in fetal wound healing

1991 • 418 citations

Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

1983 • 414 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

HUMAN WOUND REPAIR

1968 • 396 citations

Platelet-derived growth factor BB for the treatment of chronic pressure ulcers

1992 • 389 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

The fibroblast growth factor family: Structural and biological properties

1989 • 362 citations

Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.

1989 • 346 citations

Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

1982 • 340 citations

Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing.

1978 • 328 citations

Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth

1985 • 328 citations

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages.

1982 • 326 citations

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.

1988 • 324 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Sustained release of epidermal growth factor accelerates wound repair.

1985 • 309 citations

Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor.

1989 • 308 citations

Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.

1986 • 301 citations

Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors.

1979 • 300 citations

Developmental expression of transforming growth factors alpha and beta in mouse fetus.

1988 • 272 citations

A glioma-derived PDGF a chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets

1988 • 264 citations

Collagenolytic activity during mammalian wound repair

1967 • 261 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Expression of basic fibroblast growth factor in normal human tissues.

1990 • 258 citations

In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins.

1988 • 249 citations

Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor.

1985 • 236 citations

Direct evidence for spatial and temporal regulation of transforming growth factor β1 expression during cutaneous wound healing

1991 • 230 citations

Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells

1985 • 226 citations

Expression of the sis gene by endothelial cells in culture and in vivo.

1984 • 221 citations

Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor.

1985 • 221 citations

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

1991 • 220 citations

Transforming growth factor beta (TGF-β) induces fibrosis in a fetal wound model

1988 • 220 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 211 citations

Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus

1984 • 203 citations

Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β

1990 • 203 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair.

1989 • 199 citations

Transforming growth factor type beta specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells.

1987 • 198 citations

Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formation

1990 • 195 citations

Basic fibroblast growth factor is efficiently released from a cytolsolic storage site through plasma membrane disruptions of endothelial cells

1991 • 193 citations

Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells.

1988 • 193 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.

1990 • 187 citations

Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells.

1986 • 173 citations

Cell migration in repair of mouse corneal epithelium.

1979 • 171 citations

Stimulatory Effects of Transforming Growth Factor-beta and Epidermal Growth Factor on Epidermal Cell Outgrowth from Porcine Skin Explant Cultures

1988 • 165 citations

Reversal of impaired wound healing in irradiated rats by platelet-derived growth faetor-BB

1989 • 161 citations

Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: incisional wound model.

1991 • 159 citations

The Biology of the Myofibroblast Relationship to Wound Contraction and Fibrocontractive Diseases

1988 • 156 citations

Human microvascular endothelial cells express receptors for platelet-derived growth factor.

1991 • 154 citations

Biosynthesis and regulation of type V collagen in diploid human fibroblasts.

1983 • 142 citations

The effect of epidermal growth factor on wound healing in mice

1982 • 137 citations

Effect of salivary glands on wound contraction in mice

1979 • 135 citations

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

1988 • 135 citations

Stimulation of Healing of Chronic Wounds by Epidermal Growth Factor

1991 • 130 citations

Acidic fibroblast growth factor promotes vascular repair.

1991 • 117 citations

Hemidesmosomes and anchoring fibril collagen appear synchronously during development and wound healing

1988 • 116 citations

Platelet-derived growth factor promotes human peripheral monocyte activation

1985 • 116 citations

TGF-β1 Accelerates Wound Healing: Reversal of Steroid-Impaired Healing in Rats and Rabbits

1991 • 114 citations

Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors

1989 • 114 citations

Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

1984 • 113 citations

Onset of endogenous synthesis of epidermal growth factor in neonatal mice

1987 • 110 citations

Stimulation of Wound Healing by Epidermal Growth Factor

1986 • 106 citations

The mechanism of accelerated corneal epithelial healing by human epidermal growth factor.

1990 • 105 citations

Structure and properties of the cellular receptor for transforming growth factor type beta

1986 • 104 citations

Effects of aFGF and bFGF on wound healing in rabbit corneas

1987 • 103 citations

Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes

1987 • 93 citations

Basic fibroblast growth factor and insulin‐like growth factor I are strong mitogens for cultured mouse keratinocytes

1988 • 92 citations

Transforming Growth Factor-β Improves Healing of Radiation-Impaired Wounds

1991 • 89 citations

A Common PDGF rEceptor Is Activated by Homodimeric A and B Forms of PDGF

1988 • 85 citations

Exogenous transforming growth factor-beta 2 enhances connective tissue formation and wound strength in guinea pig dermal wounds healing by secondary intent.

1990 • 65 citations

Improved Healing of Tympanic Membrane Perforations with Basic Fibroblast Growth Factor

1991 • 63 citations

Recombinant Human Transforming Growth Factor—Beta 1 (rhTGF-β1) Enhances Healing and Strength of Granulation Skin Wounds

1990 • 58 citations

Reversal of Adriamycin-impaired wound healing by transforming growth factor-beta.

1989 • 56 citations

Chemotactic migration of normal dermal fibroblasts towards epidermal growth factor and its modulation by platelet-derived growth factor and transforming growth factor-beta.

1990 • 55 citations

Activation of Keratinocyte Fibronectin Receptor Function During Cutaneous Wound Healing

1987 • 53 citations

Dose-dependent effects of epidermal growth factor on corneal wound healing.

1989 • 46 citations

Tyrosine phosphorylation in cells treated with transforming growth factor‐β

1986 • 42 citations

The Platelet-Derived Growth Factor Receptor

1985 • 40 citations

Eye-Derived Growth Factor Isolated from Bovine Retina and Used for Epidermal Wound Healing In Vivo

1986 • 39 citations

Control of Animal Cell Proliferation

1985 • 38 citations

Gene expression in normal and doxorubicin-impaired wounds: importance of transforming growth factor-beta.

1990 • 33 citations

Transforming Growth Factor α: In vivo Release by Normal Human Skin following UV Irradiation and Abrasion

1991 • 27 citations

Interleukin-1-Induced Changes in Extracellular Glycosaminoglycan Composition of Cutaneous Scar-Derived Fibroblasts in Culture

1988 • 15 citations