Tolerance and Ways to Break It

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Antigens in Immunity

1966 • 372 citations

T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior^#

1989 • 337 citations

The molecular and cellular basis of affinity maturation in the antibody response

1992 • 278 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

1980 • 250 citations

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

1989 • 245 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Peripheral T Cell Tolerance

1992 • 223 citations

Antigens, Lymphoid Cells and the Immune Response

1971 • 200 citations

ANTIGENS IN IMMUNITY

1964 • 174 citations

Molecular characterization of single memory B cells

1991 • 163 citations

Functional and molecular characterization of single, (4‐hydroxy‐3‐nitrophenyl)acetyl (NP)‐specific, IgG₁⁺ B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP

1992 • 159 citations

Antigens, Lymphoid Cells, and the Immune Response

1971 • 105 citations

Cellular aspects of early T-cell development

1992 • 91 citations

Tolerance susceptibility of newly generating memory B cells.

1991 • 88 citations

Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.

1988 • 60 citations

Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization.

1993 • 45 citations

A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice.

1990 • 41 citations

Memory cell generation ablated by soluble protein antigen by means of effects on T- and B-lymphocyte compartments.

1992 • 23 citations

Determinants of the B-cell response against a transgenic autoantigen.

1990 • 22 citations