Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives
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References (109)
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
1994 • 7,068 citations
Williams Textbook of Endocrinology
2016 • 3,772 citations
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
1995 • 2,525 citations
Immune-Neuro-Endocrine Interactions: Facts and Hypotheses
1996 • 1,477 citations
Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
1990 • 1,307 citations
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
1990 • 1,272 citations
The adrenal cortex.
1998 • 1,134 citations
Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis
1997 • 1,087 citations
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
1997 • 823 citations
Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.
1985 • 816 citations
Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors
1995 • 815 citations
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis
1995 • 804 citations
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
1992 • 727 citations
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
1993 • 679 citations
SPECIFIC, NONGENOMIC ACTIONS OF STEROID HORMONES
1997 • 663 citations
Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs
1991 • 606 citations
Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.
1993 • 577 citations
Low dose long-term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse events
1994 • 532 citations
Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo
1991 • 485 citations
Estrogen Promotes Angiogenic Activity in Human Umbilical Vein Endothelial Cells In Vitro and in a Murine Model
1995 • 458 citations
Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis
1987 • 450 citations
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
1995 • 440 citations
The role of nitric oxide in inflammation and immunity
1998 • 413 citations
Endothelial function in health and disease: new insights into the genesis of cardiovascular disease
1998 • 407 citations
Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester
1993 • 388 citations
Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4
1989 • 372 citations
Neural-immune interactions in health and disease.
1997 • 364 citations
Maternal-Fetal Disparity in HLA Class II Alloantigens and the Pregnancy-Induced Amelioration of Rheumatoid Arthritis
1993 • 359 citations
Up‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells
1995 • 352 citations
Nitric Oxide in the Vasculature: Physiology and Pathophysiology
1997 • 348 citations
Regulation of murine lymphokine production in vivo II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells
1990 • 324 citations
PREGNANCY AND RHEUMATOID ARTHRITIS
1997 • 311 citations
Estrogens, the immune response and autoimmunity.
1995 • 287 citations
Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance
1994 • 286 citations
Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells
1991 • 275 citations
Cell adhesion in the immune system
1993 • 262 citations
Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis.
1988 • 249 citations
Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells
1991 • 246 citations
Circadian Relationships between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis
1997 • 242 citations
Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.
1994 • 235 citations
Synovial fluid concentration of five different cytokines in rheumatic diseases.
1990 • 226 citations
Mechanism of c-fos induction by active oxygen.
1992 • 224 citations
Mediator‐induced activation of xanthine oxidase in endothelial cells
1989 • 223 citations
Androgen replacement therapy in male patients with rheumatoid arthritis
1991 • 213 citations
Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications.
1992 • 212 citations
Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.
1993 • 211 citations
Circadian rhythm of serum interleukin-6 in rheumatoid arthritis.
1994 • 206 citations
Antiinflammatory steroid action: Basic and clinical aspects
1990 • 202 citations
α-Melanocyte Stimulating Hormone in the Modulation of Host Reactions*
1993 • 201 citations
A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium
1991 • 173 citations
Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway
1997 • 164 citations
Cloning and structural characterization of the human endothelial nitric‐oxide‐synthase gene
1994 • 157 citations
Glucocorticosteroid action on the immune system: molecular and cellular aspects.
1991 • 154 citations
Inhibition of NFκB Activity through Maintenance of IκBα Levels Contributes to Dihydrotestosterone-mediated Repression of the Interleukin-6 Promoter
1996 • 151 citations
Hypothalamic-pituitary-adrenocortical axis function in premenopausal women with rheumatoid arthritis not treated with glucocorticoids.
1999 • 140 citations
Androgen receptors, 5 alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells
1994 • 138 citations
Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus.
1994 • 120 citations
A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis.
1994 • 114 citations
Maternal testosterone and fetal sex
1991 • 112 citations
Hypoxia and acidosis in chronic inflammatory arthritis; relation to vascular supply and dynamic effusion pressure.
1990 • 112 citations
Effect of Pregnancy on the Onset and Course of Rheumatoid Arthritis
1953 • 109 citations
Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect.
1997 • 101 citations
Low‐dose corticosteroids in rheumatoid arthritis. A meta‐analysis of their moderate‐term effectiveness
1996 • 99 citations
Hormonal and pregnancy relationships to rheumatoid arthritis: Convergent effects with immunologic and microvascular systems
1995 • 99 citations
ANTERIOR PITUITARY FUNCTION IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS
1996 • 94 citations
Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis.
1996 • 92 citations
Testosterone Worsens Endothelial Dysfunction Associated With Hypercholesterolemia and Environmental Tobacco Smoke Exposure in Male Rabbit Aorta 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.
1997 • 92 citations
The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon gamma and interleukin 4 production
1999 • 88 citations
Corticosteroid pulse therapy in active rheumatoid arthritis
1993 • 80 citations
HLA-linked rheumatoid arthritis.
1994 • 77 citations
Effect of Steroid Hormones and Retinoids on the Formation of Capillary-Like Tubular Structures of Human Microvascular Endothelial Cells in Fibrin Matrices Is Related to Urokinase Expression
1998 • 77 citations
Relations between steroid hormones and cytokines in rheumatoid arthritis and systemic lupus erythematosus
1998 • 73 citations
Cyclooxygenase 1 and 2 in rheumatic disease: Implications fornonsteroidal anti-inflammatory drug therapy
1996 • 71 citations
Hypothalamic-pituitary-mediated immunomodulation: arginine vasopressin is a neuroendocrine immune mediator
1998 • 70 citations
alpha-Melanocyte stimulating hormone in the modulation of host reactions
1993 • 70 citations
Does differential neuroendocrine control of cytokine production govern the expression of autoimmune diseases in pregnancy and the postpartum period?
1997 • 70 citations
Circadian Relationships between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis
1997 • 61 citations
Estrogens and Rheumatoid Arthritis
1992 • 58 citations
Adjuvant oestrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis.
1993 • 55 citations
Perturbations of hypothalamic-pituitary-gonadal (HPG) axis and adrenal androgen (AA) functions in rheumatoid arthritis
1996 • 53 citations
Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus
1994 • 51 citations
HYPOTHALAMIC-PITUITARY MEDIATED MODULATION OF IMMUNE FUNCTION: PROLACTIN AS A NEUROIMMUNE PEPTIDE
1991 • 50 citations
Methylprednisolone inhibits uptake of Ca2+ and Na+ ions into concanavalin A-stimulated thymocytes
1997 • 50 citations
Relationship between endocrine, immune, and clinical variables in patients with systemic lupus erythematosus.
1997 • 49 citations
Neuroendocrine immune responses to inflammation: the concept of the neuroendocrine immune loop
1996 • 46 citations
Biphasic estrogen response on bovine adrenal medulla capillary endothelial cell adhesion, proliferation and tube formation.
1997 • 44 citations
Androgen metabolism and inhibition of interleukin‐1 synthesis in primary cultured human synovial macrophages
1995 • 43 citations
Adjuvant oestrogen treatment increases bone mineral density in postmenopausal women with rheumatoid arthritis.
1993 • 43 citations
Integrated hormonal-immunological-vascular (H-I-V triad) systems interactions in the rheumatic diseases.
1995 • 42 citations
Estradiol-17β regulates the induction of VCAM-1 mRNA expression by interleukin-1β in human umbilical vein endothelial cells
1994 • 42 citations
Endogenous Nitric Oxide Modulates Endothelin-1 Induced Contraction of Bovine Oviduct
1994 • 42 citations
Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions
1994 • 41 citations
Cytokines and anti-cytokines
1989 • 38 citations
An imaginative approach to synovitis--the role of hypoxic reperfusion damage in arthritis.
1993 • 36 citations
The roles of steroid hormones in arthritis
1998 • 31 citations
Clinical Maternal-Fetal Medicine Online
2021 • 31 citations
Prevention of glucocorticoid induced osteoporosis
1997 • 26 citations
Dilemmas of low dosage glucocorticoid treatment in rheumatoid arthritis: considerations of timing
1997 • 25 citations
Do sex hormones modulate the synovial macrophages in rheumatoid arthritis?
1997 • 25 citations
A controlled trial of nandrolone decanoate in the treatment of rheumatoid arthritis in postmenopausal women.
1987 • 23 citations
Introduction
1999 • 23 citations
The neuroendocrine immunology of rheumatoid arthritis
1996 • 22 citations
Rheumatic diseases and the environment.
2000 • 19 citations
Corticosteroids in Rheumatoid Arthritis
1995 • 15 citations
The Michael Mason Prize Essay 1996. Role of adhesion mechanisms in the pathogenesis of chronic synovitis
1996 • 15 citations
Rheumatic Diseases and the Environment
1998 • 13 citations
Dangers of low-dose corticosteroid therapy in rheumatoid arthritis.
1997 • 11 citations
Benefits of low-dose corticosteroids in rheumatoid arthritis.
1997 • 10 citations
Corticotropin releasing hormone and the hypothalamic-pituitary-adrenal axis in the regulation of inflammatory arthritis.
1993 • 8 citations