Hepatic Veno-Occlusive Disease following Hematopoietic Stem Cell Transplantation

Veno-occlusive Disease of the Liver and Multiorgan Failure after Bone Marrow Transplantation: A Cohort Study of 355 Patients

1993 • 1,173 citations

Venocclusive Disease of the Liver after Bone Marrow Transplantation: Diagnosis, Incidence, and Predisposing Factors

1984 • 845 citations

The syndrome of hepatic veno-occlusive disease after marrow transplantation

1995 • 475 citations

Pharmacokinetics of busulfan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation

1989 • 408 citations

Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party.

1998 • 344 citations

Withdrawing Life Support from Mechanically Ventilated Recipients of Bone Marrow Transplants: A Case for Evidence-Based Guidelines

1996 • 328 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Venoocclusive disease of the liver after marrow transplantation: Histological correlates of clinical signs and symptoms

1994 • 291 citations

An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation

1980 • 289 citations

Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation.

1993 • 257 citations

Treatment of Severe Veno-Occlusive Disease With Defibrotide: Compassionate Use Results in Response Without Significant Toxicity in a High-Risk Population

1998 • 255 citations

Acute Renal Failure Following Bone Marrow Transplantation: A Retrospective Study of 272 Patients

1989 • 251 citations

Busulfan disposition: the role of therapeutic monitoring in bone marrow transplantation induction regimens.

1993 • 218 citations

Cellular Target of Cyclophosphamide Toxicity in the Murine Liver: Role of Glutathione and Site of Metabolic Activation

1996 • 195 citations

Treatment of Hepatic Venocclusive Disease With Recombinant Human Tissue Plasminogen Activator and Heparin in 42 Marrow Transplant Patients

1997 • 189 citations

Defibrotide for the treatment of hepatic veno‐occlusive disease: results of the European compassionate‐use study

2000 • 184 citations

Ursodiol Prophylaxis against Hepatic Complications of Allogeneic Bone Marrow Transplantation

1998 • 184 citations

Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules.

1987 • 184 citations

Plasma antioxidant status after high-dose chemotherapy: a randomized trial of parenteral nutrition in bone marrow transplantation patients

2000 • 172 citations

UTILITY OF TRANSVENOUS LIVER BIOPSIES AND WEDGED HEPATIC VENOUS PRESSURE MEASUREMENTS IN SIXTY MARROW TRANSPLANT RECIPIENTS

1995 • 160 citations

Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology

1991 • 159 citations

The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity

2000 • 147 citations

The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation

2000 • 146 citations

Plasminogen Activator Inhibitor-1 Confirms the Diagnosis of Hepatic Veno-Occlusive Disease in Patients With Hyperbilirubinemia After Bone Marrow Transplantation

1997 • 143 citations

Defibrotide

1993 • 133 citations

Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat

2000 • 131 citations

Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients.

1996 • 125 citations

Transjugular liver biopsy in BMT.

1993 • 110 citations

Endothelial dysfunction after bone marrow transplantation: Increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications

1998 • 107 citations

Recombinant human tissue plasminogen activator for the treatment of established severe venocclusive disease of the liver after bone marrow transplantation

1992 • 101 citations

A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation

1993 • 99 citations

LOW MOLECULAR WEIGHT HEPARIN FOR THE PREVENTION OF VENO-OCCLUSIVE DISEASE OF THE LIVER IN BONE MARROW TRANSPLANTATION PATIENTS1

1996 • 99 citations

Transjugular intrahepatic portosystemic shunt for the management of severe venoocclusive disease following bone marrow transplantation

1996 • 99 citations

Hepatic venous outflow obstruction: evaluation with pulsed duplex sonography.

1989 • 92 citations

Liver veno-occlusive disease after bone marrow transplantation changes in coagulation parameters and endothelial markers

1991 • 90 citations

Doppler sonography: a noninvasive method for evaluation of hepatic venocclusive disease.

1990 • 90 citations

THE PATHOLOGY, DIAGNOSIS, AND TREATMENT OF HEPATIC VENO‐OCCLUSIVE DISEASE: CURRENT STATUS AND NOVEL APPROACHES

1999 • 90 citations

Busulfan pharmacokinetics in bone marrow transplant patients: is drug monitoring warranted?

1994 • 89 citations

Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venocclusive disease of the liver

1993 • 89 citations

Glutathione monoethyl ester can selectively protect liver from high dose BCNU or cyclophosphamide

1988 • 84 citations

Defibrotide, a single-stranded polydeoxyribonucleotide acting as an adenosine receptor agonist

1993 • 83 citations

Optimization of busulfan dosage in children undergoing bone marrow transplantation: a pharmacokinetic study of dose escalation

1992 • 82 citations

Physiologic significance and regulation of hepatocellular heterogeneity

1988 • 81 citations

Therapeutic efficacy of autologous blood stem cell transplantation (ABSCT): the role of cytotoxic/cytokine stem cell mobilization.

1990 • 81 citations

Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver

1986 • 81 citations

Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense.

1994 • 81 citations

N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation

2000 • 79 citations

Changes in hemostatic parameters in hepatic veno-occlusive disease following bone marrow transplantation

1997 • 68 citations

Acute effects of defibrotide, an experimental antithrombotic agent, on fibrinolysis and blood prostanoids in man

1988 • 67 citations

Glutathione Defense in Non-Parenchymal Cells

1998 • 64 citations

Glutamine and vitamin E in the treatment of hepatic veno-occlusive disease following high-dose chemotherapy

1998 • 62 citations

Defibrotide Stimulates Expression of Thrombomodulin in Human Endothelial Cells

1994 • 62 citations

Phase II trial of heparin prophylaxis for veno-occlusive disease of the liver in children undergoing bone marrow transplantation.

1996 • 61 citations

Isolation and Identification of Aptamers from Defibrotide That Act as Thrombin Antagonists in Vitro

1994 • 60 citations

Multiple Organ Dysfunction Syndrome in Bone Marrow Transplantation

1995 • 60 citations

Veno-occlusive disease of the liver complicating ABMT successfully treated with recombinant tissue plasminogen activator (rt-PA).

1990 • 58 citations

von Willebrand factor as a marker of endothelial cell activation following BMT.

1992 • 58 citations

Antithrombin-III for the treatment of chemotherapy-induced organ dysfunction following bone marrow transplantation

1997 • 58 citations

Pentoxifylline, ciprofloxacin and prednisone failed to prevent transplant-related toxicities in bone marrow transplant recipients and were associated with an increased incidence of infectious complications

1997 • 53 citations

Parameters of the fibrinolytic system in patients undergoing BMT: elevation of PAI-1 in veno-occlusive disease.

1994 • 53 citations

Transjugular intrahepatic portosystemic shunting (TIPS) for treatment of severe hepatic veno-occlusive disease.

1996 • 52 citations

Monitoring of C-reactive protein after allogeneic bone marrow transplantation identifies patients at risk of severe transplant-related complications and mortality

1998 • 49 citations

Defibrotide, by enhancing prostacyclin generation, prevents endothelin-1 induced contraction in human saphenous veins

1990 • 48 citations

Allogeneic liver transplantation for hepatic veno-occlusive disease after bone marrow transplantation--clinical and immunological considerations.

1995 • 47 citations

Endothelium and bone marrow transplantation.

1996 • 45 citations

TREATMENT OF HEPATIC VENOOCCLUSIVE DISEASE WITH RECOMBINANT HUMAN TISSUE PLAMINOGEN ACTIVATOR OR ORTHOTOPIC LIVER TRANSPLANTATION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION1

1996 • 45 citations

IL-6 and IL-8 levels in plasma during hematopoietic progenitor transplantation.

1998 • 44 citations

Monitoring of veno-occlusive disease after bone marrow transplantation by serum aminopropeptide of type III procollagen

1993 • 43 citations

Serum procollagen type III is an early and sensitive marker for veno- occlusive disease of the liver in children undergoing bone marrow transplantation

1994 • 43 citations

Hepatic veins of monkeys with veno-occlusive disease. Sequential ultrastructural changes.

1969 • 43 citations

Hepatic stellate cells (Ito cells) in veno‐occlusive disease of the liver after allogeneic bone marrow transplantation

1999 • 42 citations

MR imaging findings in two patients with hepatic veno-occlusive disease following bone marrow transplantation

2000 • 41 citations

Marked enzymuria after bone marrow transplantation

1995 • 41 citations

Recombinant human tissue plasminogen activator for the treatment of severe hepatic veno-occlusive disease in pediatric bone marrow transplant patients.

1996 • 38 citations

Recombinant tissue plasminogen activator (rtPA) for the treatment of hepatic veno-occlusive disease (VOD)

1999 • 38 citations

N-terminal peptide of type III procollagen: a marker for the development of hepatic veno-occlusive disease after BMT and a basis for determining the timing of prophylactic heparin.

1993 • 37 citations

Defibrotide as salvage therapy for refractory veno-occlusive disease of the liver complicating allogeneic bone marrow transplantation

1999 • 36 citations

Antithrombotic effect and clinical potential of defibrotide.

1993 • 34 citations

Sonographic diagnosis and hemodynamic correlation in veno-occlusive disease of the liver

1993 • 34 citations

Improvement of Walking Distance by Defibrotide in Patients with Intermittent Claudication

2000 • 34 citations

Tissue plasminogen activator (tPA) as therapy for hepatotoxicity following bone marrow transplantation

1999 • 32 citations

Recombinant tissue plasminogen activator (rt‐PA) for veno‐occlusive liver disease in pediatric autologous bone marrow transplant patients

1994 • 28 citations

Hepatic veno-occlusive disease following bone marrow transplantation treated by prostaglandin E1.

1991 • 19 citations

Treatment of hepatic veno-occlusive disease with low-dose tissue plasminogen activator: impact on coagulation profile.

1996 • 16 citations

Color-flow imaging sonography of portal and hepatic vein flow to monitor fibrinolytic therapy with r-TPA for veno-occlusive disease following myeloablative treatment

1998 • 14 citations

Veno-occlusive disease (VOD) of the liver in Korean patients following allogeneic bone marrow transplantation (BMT): efficacy of recombinant human tissue plasminogen activator (rt-PA) treatment

1996 • 14 citations

Modulation of Endothelium by Heparin and Related Polyelectrolytes

1996 • 13 citations

Successful therapy of transplant-associated veno-occlusive disease with a combination of tissue plasminogen activator and defibrotide

2000 • 13 citations

Plasma thrombopoietin levels in marrow transplant patients with veno-occlusive disease of the liver

1998 • 13 citations

A LIGHT AND SCANNING ELECTRON MICROSCOPIC STUDY OF HEPATIC VENO‐OCCLUSIVE DISEASE

1987 • 13 citations

Successful treatment of an infant with veno-occlusive disease developed after allogeneic bone marrow transplantation by tissue plasminogen activator, heparin and prostaglandin E1

1995 • 12 citations

The action of polyanionic agents defibrotide and pentosan sulphate on fibrinolytic activity in the laboratory rat

1996 • 11 citations

[Percutaneous intrahepatic portosystemic shunting in the treatment of veno-occlusive disease of the liver after bone marrow transplantation].

2000 • 11 citations

Multiple organ dysfunction syndrome in bone marrow transplantation

1995 • 10 citations

Plasma levels of D‐dimer and circulating endothelial adhesion molecules in veno‐occlusive disease of the liver following allogeneic bone marrow transplantation

1998 • 10 citations

The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno‐occlusive disease after stem cell transplantation

2000 • 6 citations

Recombinant tissue plasminogen activator (rTPA) for hepatic veno-occlusive disease after allogeneic BMT in a pediatric patient.

1995 • 6 citations