Treatment of Severe Veno-Occlusive Disease With Defibrotide: Compassionate Use Results in Response Without Significant Toxicity in a High-Risk Population

Veno-occlusive Disease of the Liver and Multiorgan Failure after Bone Marrow Transplantation: A Cohort Study of 355 Patients

1993 • 1,173 citations

VENOOCCLUSIVE DISEASE OF THE LIVER FOLLOWING BONE MARROW TRANSPLANTATION

1987 • 898 citations

Regimen-related toxicity in patients undergoing bone marrow transplantation.

1988 • 876 citations

Venocclusive Disease of the Liver after Bone Marrow Transplantation: Diagnosis, Incidence, and Predisposing Factors

1984 • 845 citations

The syndrome of hepatic veno-occlusive disease after marrow transplantation

1995 • 475 citations

Withdrawing Life Support from Mechanically Ventilated Recipients of Bone Marrow Transplants: A Case for Evidence-Based Guidelines

1996 • 328 citations

Venoocclusive disease of the liver after marrow transplantation: Histological correlates of clinical signs and symptoms

1994 • 291 citations

Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation.

1993 • 257 citations

Acute Renal Failure Following Bone Marrow Transplantation: A Retrospective Study of 272 Patients

1989 • 251 citations

Cellular Target of Cyclophosphamide Toxicity in the Murine Liver: Role of Glutathione and Site of Metabolic Activation

1996 • 195 citations

Treatment of Hepatic Venocclusive Disease With Recombinant Human Tissue Plasminogen Activator and Heparin in 42 Marrow Transplant Patients

1997 • 189 citations

Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules.

1987 • 184 citations

Plasminogen Activator Inhibitor-1 Confirms the Diagnosis of Hepatic Veno-Occlusive Disease in Patients With Hyperbilirubinemia After Bone Marrow Transplantation

1997 • 143 citations

Hepatic veno-occlusive disease

1986 • 143 citations

Defibrotide

1993 • 133 citations

Recombinant human tissue plasminogen activator for the treatment of established severe venocclusive disease of the liver after bone marrow transplantation

1992 • 101 citations

Liver veno-occlusive disease after bone marrow transplantation changes in coagulation parameters and endothelial markers

1991 • 90 citations

Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venocclusive disease of the liver

1993 • 89 citations

Defibrotide, a single-stranded polydeoxyribonucleotide acting as an adenosine receptor agonist

1993 • 83 citations

Hepatic venoocclusive disease in autologous bone marrow transplantation of solid tumors and lymphomas.

1990 • 72 citations

Acute effects of defibrotide, an experimental antithrombotic agent, on fibrinolysis and blood prostanoids in man

1988 • 67 citations

Defibrotide Stimulates Expression of Thrombomodulin in Human Endothelial Cells

1994 • 62 citations

Multiple Organ Dysfunction Syndrome in Bone Marrow Transplantation

1995 • 60 citations

Isolation and Identification of Aptamers from Defibrotide That Act as Thrombin Antagonists in Vitro

1994 • 60 citations

Parameters of the fibrinolytic system in patients undergoing BMT: elevation of PAI-1 in veno-occlusive disease.

1994 • 53 citations

A comparison of clinical criteria for the diagnosis of veno-occlusive disease of the liver after bone marrow transplantation.

1992 • 53 citations

Defibrotide, by enhancing prostacyclin generation, prevents endothelin-1 induced contraction in human saphenous veins

1990 • 48 citations

Antithrombotic effect and clinical potential of defibrotide.

1993 • 34 citations

Selective stimulation of coronary vascular PGI2 but not of platelet thromboxane formation by defibrotide in the platelet perfused heart

1985 • 31 citations

Effect of a New Antithrombotic Agent (Defibrotide) in Acute Renal Failure Due to Thrombotic Microangiopathy

1985 • 29 citations

An integrated view of the activities of defibrotide.

1996 • 28 citations

In vitro Inhibition by Defibrotide of Monocyte Superoxide Anion Generation: A Possible Mechanism for the Antithrombotic Effect of a Polydeoxyribonucleotide-Derived Drug

1991 • 25 citations

Defibrotide Inhibits Platelet Activation by Cathepsin G Released From Stimulated Polymorphonuclear Leukocytes

1992 • 25 citations

Section Review—Cardiovascular & Renal: Recent Developments in Antithrombotic Agents

1995 • 20 citations

Hepatic veno-occlusive disease following bone marrow transplantation treated by prostaglandin E1.

1991 • 19 citations

IMMUNOSUPPRESSIVE EFFECTS OF DEFIBROTIDE

1993 • 17 citations

Modulation of Endothelium by Heparin and Related Polyelectrolytes

1996 • 13 citations

Modulation of endothelial and platelet function by a polydeoxyribonucleotide derived drug “defibrotide”. A dual mechanism in the control of vascular pathology

1993 • 12 citations

Modulation of arachidonate metabolite generation in human blood by oral defibrotide.

1991 • 9 citations

Defibrotide Inhibits Ca2+ Dependent Neutrophil Activation: Implications for its Pharmacological Activity in Vascular Disorders

1991 • 4 citations