Retinoic Acid-responsive Enhancers Located 3ʹ of the Hox A and Hox B Homeobox Gene Clusters

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Hox genes in vertebrate development

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Retinoic Acid Embryopathy

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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

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Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

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9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

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The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

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Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Homeodomain-DNA recognition

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Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

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The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

Morphogenesis of malformations in hamsters caused by retinoic acid: Relation to dose and stage at treatment

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Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

1995 • 493 citations

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

1992 • 467 citations

Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity

1992 • 461 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

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Respecification of vertebral identities by retinoic acid

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The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification

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Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1

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Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6

1992 • 268 citations

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1990 • 252 citations

Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos.

1991 • 247 citations

Hox genes and pattern formation in the branchial region of the vertebrate head

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Retinoic acid causes abnormal development and segmental patterning of the anterior hindbrain in Xenopus embryos

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Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox.

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Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila

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Retinoic acid modifies development of the midbrain-hindbrain border and affects cranial ganglion formation in zebrafish embryos

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An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.

1988 • 176 citations

Retinoic acid perturbs the expression of Xhox.lab genes and alters mesodermal determination in Xenopus laevis.

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An early marker of axial pattern in the chick embryo and its respecification by retinoic acid

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Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.

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Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene.

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Clusters of Master Control Genes Regulate the Development of Higher Organisms

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Hox Codes and Positional Specification in Vertebrate Embryonic Axes

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Pituitary Pro-Opiomelanocortin Gene Expression Requires Synergistic Interactions of Several Regulatory Elements

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4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.

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Developmental regulation of human β-globin gene transcription: a switch of loyalties?

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DNA Binding Specificity Determinants in MADS-Box Transcription Factors

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Retinoic acid and homeobox gene regulation

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Reversal of axonal pathways from rhombomere 3 correlates with extra hox expression domains

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A retinoic acid-triggered cascade of HOXB1 gene activation.

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Colinearity in the Xenopus laevis Hox-2 complex

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Regulation of the human HOXD4 gene by retinoids

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Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.

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The Dominant Control Region of the Human β‐Globin Domain

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Retinoic acid affects central nervous system development of Xenopus by changing cell fate

1993 • 15 citations