Cyclooxygenase-2 Is Required for Tumor Necrosis Factor-α– and Angiotensin II–Mediated Proliferation of Vascular Smooth Muscle Cells

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

1999 • 1,315 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.

1999 • 594 citations

Renal injury from angiotensin II-mediated hypertension.

1992 • 546 citations

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

1993 • 470 citations

Elevated cyclooxygenase-2 levels in Min mouse adenomas

1996 • 311 citations

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells.

1994 • 230 citations

Activation of human peripheral monocytes by angiotensin II

1994 • 210 citations

Tumor Necrosis Factor-α Activates Smooth Muscle Cell Migration in Culture and Is Expressed in the Balloon-Injured Rat Aorta

1997 • 162 citations

TNF-α–Induced Migration of Vascular Smooth Muscle Cells Is MAPK Dependent

1999 • 157 citations

Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells.

1994 • 154 citations

The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

1997 • 150 citations

Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.

1994 • 144 citations

Thromboxane A ₂ and Vascular Smooth Muscle Cell Proliferation

1995 • 134 citations

Proliferating Arterial Smooth Muscle Cells After Balloon Injury Express TNF-α but Not Interleukin-1 or Basic Fibroblast Growth Factor

1996 • 132 citations

Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines

1996 • 115 citations

Angiotensin II induces TNF production by the thick ascending limb: functional implications

1998 • 100 citations

Prostacyclin Synthase Gene Transfer Accelerates Reendothelialization and Inhibits Neointimal Formation in Rat Carotid Arteries After Balloon Injury

1999 • 78 citations

Cyclooxygenase-2 expression and function in the medullary thick ascending limb

1999 • 74 citations

Tumor necrosis factor-α-angiotensin interactions and regulation of blood pressure

1997 • 62 citations

Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells

1998 • 56 citations

Selective Inhibition by Nimesulide, a Novel Non‐steroidal Anti‐inflammatory Drug, with Prostaglandin Endoperoxide Synthase‐2 Activity In‐vitro

1995 • 49 citations

Prostacyclin agonists reduce early atherosclerosis in hyperlipidemic hamsters. Octimibate and BMY 42393 suppress monocyte chemotaxis, macrophage cholesteryl ester accumulation, scavenger receptor activity, and tumor necrosis factor production.

1993 • 46 citations

Thrombin-Induced Mitogenesis in Coronary Artery Smooth Muscle Cells Is Potentiated by Thromboxane A ₂ and Involves Upregulation of Thromboxane Receptor mRNA

1998 • 39 citations

Thromboxane/Prostaglandin Endoperoxide–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells Is Signaled by Protein Kinase C–Dependent Increases in Transforming Growth Factor-β

1996 • 26 citations

Role of thromboxane A2 in mitogenesis of vascular smooth muscle cells

1997 • 24 citations

The role of cyclooxygenase‐1 and cyclooxygenase‐2 in lipopolysaccharide and interleukin‐1 stimulated enterocyte prostanoid formation

1998 • 18 citations

Role of chloride in the variable response of the kidney to cyclooxygenase inhibition

1995 • 15 citations

Antimitotic actions of vasodilatory prostaglandins — clinical aspects

1997 • 13 citations

Low-Affinity Thromboxane Receptor Mediates Proliferation in Cultured Vascular Smooth Muscle Cells of Rats

1997 • 12 citations

Thromboxane A2 Potentiates Thrombin-Induced Proliferation of Coronary Artery Smooth Muscle Cells

1997 • 9 citations

Angiopeptin, a Somatostatin Analogue, Inhibits Rat Coronary Artery and Aorta Smooth Muscle Cell Proliferation Induced by the Thromboxane A2 Mimetic U46619

1997 • 8 citations