Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Inhibitory B7-family molecules in the tumour microenvironment

2008 • 1,511 citations

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

2003 • 1,255 citations

Diagnosis and Treatment of Hepatocellular Carcinoma

2008 • 1,109 citations

Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection

2007 • 1,060 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

2007 • 830 citations

Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

2009 • 770 citations

Enhancing SIV-specific immunity in vivo by PD-1 blockade

2008 • 731 citations

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

1998 • 611 citations

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

2003 • 481 citations

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

2008 • 480 citations

Immune resistance orchestrated by the tumor microenvironment

2006 • 422 citations

Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)

2006 • 413 citations

PD-1–PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma

2008 • 392 citations

B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes

2004 • 375 citations

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

2003 • 373 citations

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

2008 • 288 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

Cellular and molecular mechanisms of liver tolerance

2006 • 227 citations

Oncogenic Function of ATDC in Pancreatic Cancer through Wnt Pathway Activation and β-Catenin Stabilization

2009 • 207 citations

FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease

2009 • 176 citations

Dynamic Programmed Death 1 Expression by Virus-Specific CD8 T Cells Correlates With the Outcome of Acute Hepatitis B

2008 • 160 citations

High PD-L1/CD86 Ratio on Plasmacytoid Dendritic Cells Correlates With Elevated T-Regulatory Cells in Liver Transplant Tolerance

2008 • 150 citations

Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion

2008 • 146 citations

B7-H1 Up-Regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B

2007 • 121 citations

Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells

2006 • 67 citations

Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts

2005 • 37 citations