Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion

Histological grading and staging of chronic hepatitis

1995 • 4,862 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Immunology of hepatitis B virus and hepatitis C virus infection

2005 • 1,579 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

CD8⁺T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

2002 • 913 citations

Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

2007 • 847 citations

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

1990 • 578 citations

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

2006 • 558 citations

Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.

1990 • 503 citations

Sustained Dysfunction of Antiviral CD8⁺T Lymphocytes after Infection with Hepatitis C Virus

2001 • 496 citations

The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.

1995 • 483 citations

Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection

2003 • 387 citations

Longitudinal Analysis of CD8⁺T Cells Specific for Structural and Nonstructural Hepatitis B Virus Proteins in Patients with Chronic Hepatitis B: Implications for Immunotherapy

2004 • 382 citations

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8⁺T Cells Associated with Reversible Immune Dysfunction

2007 • 365 citations

Association of Hepatitis C Virus–Specific CD8⁺T Cells with Viral Clearance in Acute Hepatitis C

2000 • 362 citations

Predictors of HBeAg loss after lamivudine treatment for chronic hepatitis B

2002 • 306 citations

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

2007 • 281 citations

Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins

2005 • 206 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8 ⁺ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection

2006 • 191 citations

Real-time PCR quantitation of hepatitis B virus DNA using automated sample preparation and murine cytomegalovirus internal control

2005 • 146 citations

Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: Antiviral and immunological activity

2005 • 90 citations

Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection

1996 • 85 citations

CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients − reversal by highly active anti-retroviral therapy (HAART)

2006 • 75 citations

Translation of immunological knowledge into better treatments of chronic hepatitis B

2003 • 67 citations

Hepatitis B Virus e Antigen Loss during Adefovir Dipivoxil Therapy Is Associated with Enhanced Virus-Specific CD4⁺T-Cell Reactivity

2007 • 49 citations

Immunological techniques in viral hepatitis

2007 • 46 citations

Impact of Early Viral Kinetics on T-Cell Reactivity during Antiviral Therapy in Chronic Hepatitis B

2007 • 42 citations

Novel strategies to eliminate persistent viral infections

2008 • 33 citations

Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus

2006 • 24 citations