BCL₁, a Murine Model for Chronic Lymphocytic Leukemia: Use of the Surface Immunoglobulin Idiotype for the Detection and Treatment of Tumor

Towards a network theory of the immune system.

1974 • 3,379 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

The route of re-circulation of lymphocytes in the rat

1964 • 1,449 citations

A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXES

1970 • 1,144 citations

Clonal origin of human tumors

1976 • 662 citations

Lymphosarcoma: virus-induced thymic-independent disease in mice.

1970 • 414 citations

Prolymphocytic Leukaemia

1974 • 413 citations

ANALYSIS OF CELL POPULATIONS WITH A FLUORESCENCE‐ACTIVATED CELL SORTER*

1975 • 405 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

Membrane receptors of lymphocytes

1978 • 341 citations

Thymus-Independent B-Cell Induction and Paralysis

1975 • 304 citations

Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.

1978 • 296 citations

Lymphocyte Receptors for Immunoglobulin

1976 • 296 citations

Spontaneous murine B-cell leukaemia

1978 • 264 citations

Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.

1975 • 228 citations

B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.

1977 • 212 citations

Receptor-mediated inactivation of early B lymphocytes

1975 • 187 citations

Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

1977 • 178 citations

‘Prolymphocytoid’ Transformation of Chronic Lymphocytic Leukaemia

1979 • 176 citations

Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.

1978 • 173 citations

Inhibition of mitogenic stimulation of mouse lymphocytes by anti‐mouse immunoglobulin antibodies. I. Mode of action

1974 • 165 citations

Mouse Bone Marrow Lymphocytes and Their Differentiation

1974 • 154 citations

IgD and B Cell Differentiation

1977 • 127 citations

Histopathology and Diagnosis of Non-Hodgkin’s Lymphomas

1978 • 120 citations

Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.

1977 • 120 citations

Synthesis, surface deposition, and secretion of immunoglobulins by abelson virus-transformed lymphosarcoma cell lines

1975 • 111 citations

A new alloantigen expressed selectively on B cells: the Lyb-2 system

1976 • 101 citations

Activation of mouse lymphocytes by anti-immunoglobulin. II. A thymus-independent response by a mature subset of B lymphocytes.

1978 • 100 citations

Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.

1977 • 93 citations

Surface immunoglobulins of lipopolysaccharide‐stimulated spleen cells The behaviour of IgM, IgD and IgG

1977 • 92 citations

Abelson virus-transformed haematopoietic cell lines with pre-B-cell characteristics

1979 • 82 citations

Prolymphocytic leukemia. Clinical, histopathological, and cytochemical observations

1978 • 73 citations

B-cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia.

1978 • 73 citations

The ontogeny of murine B lymphocytes. I. Induction of phenotypic conversion of Ia-to Ia+ lymphocytes.

1975 • 72 citations

The role of surface IgD in the response to thymic-independent antigens.

1977 • 66 citations

Regulation of the immune response to tumor antigen. IV. Tumor antigen-specific suppressor factor(s) bear I-J determinants and induce suppressor T cells in vivo.

1978 • 62 citations

Loss of surface IgD by human B lymphocytes during polyclonal activation^*

1977 • 61 citations

Idiotype-Specific Transplantation Resistance to MOPC-315: Abrogation by Post-Immunization Thymectomy

1978 • 60 citations

Role of different T cells sets in the rejection of syngeneic chemically induced tumors.

1979 • 60 citations

Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens.

1979 • 59 citations

IDIOTYPIC UNIFORMITY OF CELL SURFACE IMMUNOGLOBULIN IN CHRONIC LYMPHOCYTIC LEUKEMIA

1974 • 57 citations

Antigen-induced murine B cell lymphomas. II. Exploitation of the surface idiotype as tumor specific antigen.

1978 • 55 citations

Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: identification of tumor origin by idiotypic analysis.

1978 • 55 citations

Anti-idiotype sera raised against surface immunoglobulin of human neoplastic lymphocytes.

1976 • 54 citations

Requirements for Mitogenic Stimulation of Murine B Cells by Soluble Anti-IgM Antibodies

1979 • 53 citations

Immunoregulation of Murine Myeloma: Isologous Immunization with M315 Induces Idiotype-Specific T Cells that Suppress IgA Secretion by MOPC-315 Cells in vivo

1979 • 52 citations

Anti-immunoglobulin stimulation of murine lymphocytes. V. Age-related decline in Fc receptor-mediated immunoregulation.

1978 • 52 citations

Immune Function Cell Surface Characteristics and Maturation of B Cell Subpopulations

1975 • 51 citations

Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti‐immunoglobulin antibodies

1978 • 51 citations

The Role of Receptor IgM and IgD in Determining Triggering and Induction of Tolerance in Murine B Cells¹

1979 • 48 citations

Antigen-initiated B lymphocyte differentiation

1975 • 45 citations

Differences in the Behavior of the Membrane and Membrane-Associated Filamentous Structures in Normal and Chronic Lymphocytic Leukemia (CLL) Lymphocytes

1979 • 44 citations

Murine B Cell Leukemia (BCL1): Organ Distribution and Kinetics of Growth as Determined by Fluorescence Analysis with an Anti-Idiotypic Antibody

1979 • 43 citations

Anti-Immunoglobulin Stimulation of Murine Lymphocytes

1978 • 40 citations

Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody.

1979 • 40 citations

Regulation of the immune response to tumor antigen. VI. Differential specificities of suppressor T cells or their products and effector T cells.

1978 • 37 citations

Mechanisms of idiotype suppression. I. In vitro generation of idiotype-specific suppressor T cells by anti-idiotype antibodies and specific antigen.

1979 • 36 citations

Changes in the surface membrane of lymphocytes from patients with chronic lymphocytic leukemia and hodgkin's disease

1975 • 36 citations

Role of Different T Cell Sets in the Rejection of Syngeneic Chemically Induced Tumors

1979 • 35 citations

Impaired recirculation of b lymphocytes in chronic lymphocytic leukemia

1973 • 35 citations

Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera.

1979 • 33 citations

An IgM-producing tumor with biochemical characteristics of a small B lymphocyte

1977 • 33 citations

Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2.

1978 • 31 citations

Antigen-Induced Murine B Cell Lymphomas

1978 • 31 citations

Cell surface immunoglobulin. XV. The presence of IgM and an IgD-like molecule on the same cell in murine lymphoid tissue

1976 • 25 citations

Antigen-Induced Murine B Cell Lymphomas

1978 • 23 citations

Further Characterization of Thymic Suppressor Cells and a Factor That Suppress the Generation of Cells Cytotoxic for a Syngeneic Tumor in DBA/2 Mice

1979 • 23 citations

Cell Surface Immunoglobulin. XXII. Reappearance of Surface IgM and IgD on Murine Splenocytes after Removal by Capping

1977 • 22 citations

Idiotype-Specific Suppression of MOPC-315 IgA Secretion in vivo: Reversible Blockade of Secretory Myeloma Cells by Soluble Mediators

1978 • 22 citations

Characterization of the Spontaneous Murine B Cell Leukemia (BCL1)

1979 • 20 citations

Characterization of a Soluble Factor that Specifically Suppresses the in Vitro Generation of Cells Cytotoxic for Syngeneic Tumor Cells in Mice

1978 • 20 citations

Soluble Helper Factor(s) Participates in the Generation of Cell Mediated Cytotoxicity Directed against Syngeneic Tumor Cells

1979 • 19 citations

The ontogeny of B lymphocytes IV. Induction signals mediating phenotypic conversion of PC.1⁻ to PC.1⁺B cells

1977 • 19 citations

Properties of murine leukemia-associated suppressor cells. I. Preferential suppression of thymus-dependent antibody responses and the requirement for syngeneity in the K region of the H-2 complex.

1979 • 9 citations

Surface Expression and Synthesis of I-A and I-E/C Encoded Molecules by B Lymphocytes and Ig-Secreting Cells

1979 • 8 citations

Regulation of the immune response to tumor antigen. IV. Tumor antigen-specific suppressor factor(s) bear I-J determinants and induce suppressor T cells in vivo.

1979 • 7 citations

ANTIGEN‐INITIATED B LYMPHOCYTE DIFFERENTIATION

1977 • 5 citations

Regulatory Cellular Interactions in Immune Responses

1977 • 3 citations

Tumors of Immunoglobulin-Producing Cells and Thymus-Derived Lymphocytes

1976 • 3 citations

Surface Antigens and Markers on B Lymphocytes

1977 • 2 citations