Serotonin 5-HT1A Receptors Regulate AMPA Receptor Channels through Inhibiting Ca2+/Calmodulin-dependent Kinase II in Prefrontal Cortical Pyramidal Neurons

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Exploratory Data Analysis

1977 • 12,265 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Dysfunction in the Neural Circuitry of Emotion Regulation--A Possible Prelude to Violence

2000 • 1,855 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Exploratory Data Analysis.

1978 • 1,411 citations

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

1998 • 1,045 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit

1996 • 802 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

1983 • 617 citations

A Model of Synaptic Memory

2001 • 488 citations

Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons

1991 • 486 citations

Gating of CaMKII by cAMP-Regulated Protein Phosphatase Activity During LTP

1998 • 452 citations

Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines

1997 • 446 citations

Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II

1993 • 437 citations

Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II

1997 • 434 citations

Identification of the Ca2+/Calmodulin-dependent Protein Kinase II Regulatory Phosphorylation Site in the α-Amino-3-hydroxyl-5-methyl4-isoxazole-propionate-type Glutamate Receptor

1997 • 391 citations

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

1984 • 389 citations

Spinophilin regulates the formation and function of dendritic spines

2000 • 374 citations

Immunocytochemical localization of serotonin1A receptors in the rat central nervous system

1996 • 370 citations

Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex

1990 • 314 citations

Serotonin receptors in cognitive behaviors

1997 • 299 citations

Abnormal Fear Response and Aggressive Behavior in Mutant Mice Deficient for α-Calcium-Calmodulin Kinase II

1994 • 292 citations

Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin

1999 • 287 citations

Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2+-independent activity

1988 • 283 citations

Decreased hippocampal expression of a glutamate receptor gene in schizophrenia

1991 • 241 citations

The recombinant 5‐HT_1A receptor: G protein coupling and signalling pathways

1999 • 232 citations

The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?

2001 • 214 citations

Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane- delimited, G-protein pathway

1996 • 206 citations

Serotonin Receptors Modulate GABA_AReceptor Channels through Activation of Anchored Protein Kinase C in Prefrontal Cortical Neurons

2001 • 203 citations

Change in the Shape of Dendritic Spines Caused by Overexpression of Drebrin in Cultured Cortical Neurons

1999 • 201 citations

Contrasting patterns in the localization of glutamic acid decarboxylase and Ca2+ /calmodulin protein kinase gene expression in the rat centrat nervous system

1992 • 193 citations

D5 Dopamine Receptors Enhance Zn2+-Sensitive GABAA Currents in Striatal Cholinergic Interneurons through a PKA/PP1 Cascade

1997 • 192 citations

Expression of NMDAR1, GluR1, GluR7, and KA1 Glutamate Receptor mRNAs Is Decreased in Frontal Cortex of “Neuroleptic‐Free” Schizophrenics: Evidence on Reversible Up‐Regulation by Typical Neuroleptics

1998 • 182 citations

Alterations in the cortical serotonergic system in schizophrenia: A postmortem study

1997 • 182 citations

Bistability in the Ca2+/Calmodulin-Dependent Protein Kinase-Phosphatase System

2000 • 176 citations

Glutamate receptor phosphorylation and synaptic plasticity

1994 • 175 citations

Serotonin, schizophrenia and antipsychotic drug action

1995 • 172 citations

Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs

1995 • 171 citations

Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins

1985 • 162 citations

Ultrastructural localization of 5-hydroxytryptamine1A receptors in the rat brain

1996 • 153 citations

Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia

1996 • 153 citations

5-HT1A receptor ligands in animal models of anxiety, impulsivity and depression: Multiple mechanisms of action?

1993 • 145 citations

Chronic antidepressant treatment and central 5-HT synapses

1983 • 142 citations

Neurobiology of Serotonin in Depression and Suicide^a

1997 • 127 citations

The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines.

1995 • 124 citations

Autoradiography with [3H]8-OH-DPAT reveals increases in 5-HT1A receptors in ventral prefrontal cortex in schizophrenia

1996 • 119 citations

Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins

1997 • 117 citations

Role of Calcineurin and Protein Phosphatase‐2A in the Regulation of DARPP‐32 Dephosphorylation in Neostriatal Neurons

1999 • 114 citations

DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1.

1986 • 105 citations

Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity

1990 • 98 citations

Activity‐dependent bidirectional regulation of GABA_A receptor channels by the 5‐HT₄ receptor‐mediated signalling in rat prefrontal cortical pyramidal neurons

2002 • 87 citations

Regulation of Membrane Excitability in the Central Nervous System by Serotonin Receptor Subtypes^a

1998 • 84 citations

Perspectives on the role of serotonergic mechanisms in the pharmacology of schizophrenia

1997 • 82 citations

Receptor signaling and structure: insights from serotonin-1 receptors

2001 • 72 citations

Inhibitory modulation of long-term potentiation via the 5-HT1A receptor in slices of the rat hippocampal dentate gyrus

1993 • 64 citations

The structure and signalling properties of 5-HT receptors: an endless diversity?

1998 • 60 citations

5-HT1A receptor-mediated inhibition of long-term potentiation in rat visual cortex

1998 • 56 citations