The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

Does Fast Dissociation From the Dopamine D₂ Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis

2001 • 1,113 citations

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

2001 • 1,080 citations

Gene Expression for Glutamic Acid Decarboxylase Is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics

1995 • 1,007 citations

NMDA receptor hypofunction model of schizophrenia

1999 • 1,007 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials

1999 • 807 citations

Studies of Cognitive Change in Patients With Schizophrenia Following Novel Antipsychotic Treatment

2001 • 622 citations

Comparison of human infants and rhesus monkeys on Piaget's AB task: evidence for dependence on dorsolateral prefrontal cortex

1989 • 618 citations

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1988 • 602 citations

Neurocognitive Effects of Clozapine, Olanzapine, Risperidone, and Haloperidol in Patients With Chronic Schizophrenia or Schizoaffective Disorder

2002 • 536 citations

Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy

2003 • 464 citations

A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia

2002 • 445 citations

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics

1997 • 419 citations

The Generalized Pattern of Neuropsychological Deficits in Outpatients With Chronic Schizophrenia With Heterogeneous Wisconsin Card Sorting Test Results

1991 • 409 citations

Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine

1997 • 401 citations

Dopamine D2 receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient

2001 • 377 citations

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

2002 • 370 citations

Subchronic Phencyclidine Administration Reduces Mesoprefrontal Dopamine Utilization and Impairs Prefrontal Cortical-Dependent Cognition in the Rat

1997 • 320 citations

Dopamine, the prefrontal cortex and schizophrenia

1997 • 302 citations

Induction of Metabolic Hypofunction and Neurochemical Deficits after Chronic Intermittent Exposure to Phencyclidine: Differential Modulation by Antipsychotic Drugs

2003 • 232 citations

Neuropsychological change in patients with schizophrenia after treatment with quetiapine or haloperidol.

2001 • 182 citations

Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain

1986 • 177 citations

Cognitive dysfunction in schizophrenia: comparison of treatment with atypical antipsychotic agents and conventional neuroleptic drugs

1996 • 172 citations

The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis

1996 • 169 citations

Behavioural rigidity and rule-learning deficits following isolation-rearing in the rat: neurochemical correlates

1991 • 168 citations

Calcium binding protein markers of GABA deficits in schizophrenia — post mortem studies and animal models

2004 • 149 citations

Recovery of neuropsychological functions during reduction in use of phencyclidine

1991 • 141 citations

Acute and chronic phencyclidine effects on locomotor activity, stereotypy and ataxia in rats

1981 • 141 citations

Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats

1998 • 131 citations

Sex differences in NMDA receptor mediated responses in rats

1993 • 124 citations

Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and d-amphetamine in the rat

2005 • 123 citations

The selective 5-HT2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat

1995 • 118 citations

The Cognitive Efficacy of Atypical Antipsychotics in Schizophrenia

1998 • 112 citations

The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat

2003 • 100 citations

Cognitive improvement in schizophrenia with novel antipsychotic medications

1999 • 100 citations

Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex

1998 • 92 citations

Acute and delayed effects of phencyclidine upon mRNA levels of markers of glutamatergic and GABAergic neurotransmitter function in the rat brain

2002 • 85 citations

Effects of repeated treatment with amphetamine or phencyclidine on working memory in the rat

2002 • 79 citations

Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics

1997 • 69 citations

Involvement of serotonin 2A receptors in phencyclidine-induced disruption of prepulse inhibition of the acoustic startle in rats

1999 • 68 citations

Reduced prefrontal cortical dopamine, but not acetylcholine, release in vivo after repeated, intermittent phencyclidine administration to rats

1998 • 64 citations

Cognitive and motor deficits in the performance of an object retrieval task with a barrier^detour in monkeys (Cercopithecus aethiops sabaeus) treated with MPTP: Long-term performance and effect of transparency of the barrier.

1990 • 62 citations

Behavioral effects of chronic phencyclidine administration in rats

1982 • 60 citations

Phencyclidine-induced behavioral sensitization

1994 • 57 citations

Cognitive and motor deficits in the performance of an object retrieval task with a barrier-detour in monkeys (Cercopithecus aethiops sabaeus) treated with MPTP: Long-term performance and effect of transparency of the barrier.

1990 • 54 citations

Modulation of glutamate receptors in response to the novel antipsychotic olanzapine in rats

2001 • 51 citations

The effects of olanzapine on neurocognitive functioning in medication-refractory schizophrenia

2001 • 51 citations

Neuroleptics ameliorate phencyclidine‐induced impairments of short‐term memory

2000 • 36 citations

A preliminary study of the comparative effects of olanzapine and fluphenazine on cognition in schizophrenic patients

2000 • 18 citations