Src and Rac Mediate Endothelin-1 and Lysophosphatidic Acid Stimulation of the Human Brain Natriuretic Peptide Promoter

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Cardiac fibrosis in mice lacking brain natriuretic peptide

2000 • 612 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease

1998 • 261 citations

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

1994 • 252 citations

Signaling Pathways in Cardiac Myocyte Hypertrophy

1997 • 241 citations

Bromoenol Lactone Inhibits Magnesium-dependent Phosphatidate Phosphohydrolase and Blocks Triacylglycerol Biosynthesis in Mouse P388D1 Macrophages

1996 • 218 citations

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.

1998 • 198 citations

Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.

1994 • 181 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Mediation by Arachidonic Acid Metabolites of the H₂O₂‐Induced Stimulation of Mitogen‐Activated Protein Kinases (Extracellular‐Signal‐Regulated Kinase and c‐Jun NH₂‐Terminal Kinase)

1997 • 149 citations

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.

1998 • 142 citations

Review of 10 years of the clinical use of brain natriuretic peptide in cardiology

1999 • 101 citations

Endothelin-Dependent and -Independent Components of Strain-Activated Brain Natriuretic Peptide Gene Transcription Require Extracellular Signal Regulated Kinase and p38 Mitogen-Activated Protein Kinase

2000 • 98 citations

Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.

1995 • 94 citations

Interleukin-1β Regulation of the Human Brain Natriuretic Peptide Promoter Involves Ras-, Rac-, and p38 Kinase–Dependent Pathways in Cardiac Myocytes

1999 • 92 citations

Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells

1989 • 86 citations

Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity

1996 • 79 citations

Nuclear Signaling by Endothelin-1 Requires Src Protein-tyrosine Kinases

1996 • 77 citations

Tissue-Specific Expression of the Human Brain Natriuretic Peptide Gene in Cardiac Myocytes

1996 • 74 citations

c-Src Activation Plays a Role in Endothelin-dependent Hypertrophy of the Cardiac Myocyte

1998 • 70 citations

Oncogenic src, raf, and rasStimulate a Hypertrophic Pattern of Gene Expression and Increase Cell Size in Neonatal Rat Ventricular Myocytes

1998 • 70 citations

Signal transduction during cardiac hypertrophy: the role of Gαq, PLC βI, and PKC

1999 • 62 citations

Coupling of the type A endothelin receptor to multiple responses in adult rat cardiac myocytes.

1994 • 60 citations

Endothelin-1-evoked arachidonic acid release: a Ca(2+)-dependent pathway

1996 • 56 citations

Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways

1997 • 54 citations

Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes.

1992 • 53 citations

Arachidonic acid induces the activation of the stress‐activated protein kinase, membrane ruffling and H₂O₂ production via a small GTPase Rac1

1999 • 52 citations

Endothelin stimulates degradation of phospholipids in isolated rat hearts

1991 • 51 citations

Phospholipase-A2-dependent signalling in the heart

1995 • 51 citations

Endothelin stimulates cardiac α- and β- myosin heavy chain gene expression

1992 • 43 citations

Isoproterenol and cAMP regulation of the human brain natriuretic peptide gene involves Src and Rac

2000 • 42 citations

Endothelin increases the synthesis and secretion of atrial natriuretic peptide in neonatal rat cardiocytes

1991 • 39 citations

Role of Ca ²⁺ -Independent Phospholipase A ₂ in the Regulation of Inducible Nitric Oxide Synthase in Cardiac Myocytes

2000 • 38 citations

Inhibition of 5-lipoxygenase blocks IL-1 beta-induced vascular adhesion molecule-1 gene expression in human endothelial cells.

1997 • 37 citations

Nuclear signalling by Rac GTPase: essential role of phospholipase A2

1997 • 34 citations

Phospholipase A₂Metabolites Regulate Inducible Nitric Oxide Synthase in Myocytes

1998 • 34 citations

Identification of the receptor subtype responsible for endothelin-mediated protein kinase C activation and atrial natriuretic factor secretion from atrial myocytes.

1993 • 32 citations

Agonist-induced frequency modulation of Ca2+ oscillations in salt gland secretory cells

1991 • 31 citations

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