Non-Steroidal Anti-Inflammatory Drug Gastropathy and Cytoprotection: Pathogenesis and Mechanisms Re-examined

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

1990 • 563 citations

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

1981 • 447 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa

1980 • 401 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.

1976 • 330 citations

Histologic and Microcirculatory Changes in Alcohol-Induced Gastric Lesions in the Rat: Effect of Prostaglandin Cytoprotection

1984 • 326 citations

Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury

1987 • 308 citations

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

1983 • 308 citations

A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit

1991 • 284 citations

Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach

1989 • 219 citations

Internalization of fluorescent vasotocin-receptor agonist and antagonist in the toad bladder

1990 • 211 citations

Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products

1992 • 206 citations

Rapid epithelial restitution of the rat gastric mucosa after ethanol injury.

1984 • 190 citations

Ethanol-induced injury to the rat gastric mucosa

1990 • 189 citations

Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying

1991 • 187 citations

Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation

1987 • 186 citations

Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate

1992 • 163 citations

Transforming growth factor β2 inhibits interleukin 1β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells

1991 • 162 citations

Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat

1987 • 161 citations

Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,16-dimethyl prostaglandin E2 or sodium thiosulfate

1986 • 159 citations

The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice

1987 • 159 citations

Role of oxygen-derived free radicals in indomethacin-induced gastric injury

1991 • 156 citations

Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis

1988 • 155 citations

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production

1982 • 150 citations

Reduction by cytoprotective agents of ethanol-induced damage to the rat gastric mucosa: a correlated morphological and physiological study

1982 • 125 citations

The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine

1987 • 106 citations

Interleukin-1 β induces the production of an L-arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta

1991 • 104 citations

Prostaglandin cytoprotection against ethanol-induced gastric injury in the rat

1985 • 92 citations

Focal gastric mucosal blood flow at the site of aspirin-induced ulceration

1985 • 92 citations

Microcirculatory disturbance in indomethacin-induced intestinal ulcer

1991 • 90 citations

Central action of recombinant interleukin-1 to inhibit acid secretion in rats

1990 • 88 citations

Prostacyclin and beraprost sodium as suppressors of activated rat polymorphonuclear leukocytes

1990 • 84 citations

Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins.

1990 • 84 citations

Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy

1992 • 79 citations

Inhibition of the n-formylmethionyl-leucyl-phenylalanine induced respiratory burst in human neutrophils by adrenergic agonists and prostaglandins of the E series

1981 • 72 citations

Gastric cytoprotection by sodium salicylate

1981 • 60 citations

The potentiation of taurocholate‐induced rat gastric erosions following parenteral administration of cyclo‐oxygenase inhibitors

1983 • 60 citations

Focal Gastric Mucosal Blood Flow in Aspirin-induced Ulceration

1987 • 58 citations

Microvascular injury during gastric mucosal damage by anti-inflammatory drugs in pigs and rats

1983 • 56 citations

Identification of patients at risk for gastropathy associated with NSAID use.

1990 • 53 citations

Platelet-activating factor and diseases

1989 • 51 citations

Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy

1992 • 47 citations

Gastric microvascular endothelium: a major target for aspirin‐induced injury and arachidonic acid protection. An ultrastructural analysis in the rat

1990 • 46 citations

Interleukin-1: A cytokine that has potent antisecretory and anti-ulcer actions via the central nervous system

1990 • 42 citations

Reduction of the severity of experimental gastric and duodenal ulceration by interleukin-1β

1990 • 40 citations

Effect of sialoadenectomy on ethanol-induced gastric mucosal damage in the rat: role of neutrophils

1990 • 21 citations

Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs)

1991 • 20 citations

Prostaglandin prevents aspirin injury in the canine stomach under in vivo but not in vitro conditions

1989 • 19 citations

Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy

1992 • 17 citations

Granulocytes: The culprit in ischemic damage to the intestine

1988 • 15 citations

Mechanisms underlying the protective effects of interleukin-1 in experimental NSAID-gastropathy.

1992 • 11 citations