Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

1981 • 447 citations

Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury

1987 • 308 citations

A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit

1991 • 284 citations

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist

1989 • 266 citations

Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa

1986 • 222 citations

Internalization of fluorescent vasotocin-receptor agonist and antagonist in the toad bladder

1990 • 211 citations

Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation

1987 • 186 citations

THE PHARMACOLOGY AND PATHOPHYSIOLOGY OF LEUKOTRIENE B4

1983 • 182 citations

The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice

1987 • 159 citations

Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis

1992 • 158 citations

Role of oxygen-derived free radicals in indomethacin-induced gastric injury

1991 • 156 citations

The Preclinical Pharmacology of ICI 204,219: A Peptide Leukotriene Antagonist

1990 • 155 citations

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production

1982 • 150 citations

Selective 5-lipoxygenase inhibition in ulcerative colitis

1990 • 135 citations

Gastric vasoconstrictor actions of leukotriene C4, PGF2 alpha, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo

1985 • 116 citations

The mucoid cap over superficial gastric damage in the rat

1990 • 96 citations

Focal gastric mucosal blood flow at the site of aspirin-induced ulceration

1985 • 92 citations

Vascular injury in acute gastric mucosal damage

1988 • 91 citations

Role of leukotrienes in acute gastric lesions induced by ethanol, taurocholate, aspirin, platelet-activating factor and stress in rats

1988 • 85 citations

Role of prostanoids in the protective actions of BW755C on the gastric mucosa

1985 • 77 citations

Effects of Leukotrienes on Susceptibility of the Rat Stomach to Damage and Investigation of the Mechanism of Action

1990 • 75 citations

Glucocorticoid-induced gastric mucosal damage: inhibition of leukotriene, but not prostaglandin biosynthesis

1987 • 71 citations

Is there a role for leukotrienes as mediators of ethanol-induced gastric mucosal damage?

1988 • 68 citations

Intestinal permeability, non-steroidal anti-inflammatory drug enteropathy and inflammatory bowel disease: an overview.

1989 • 63 citations

Role of leukotriene C4 in mucosal damage caused by necrotizing agents and indomethacin in the rat stomach

1991 • 62 citations

Focal Gastric Mucosal Blood Flow in Aspirin-induced Ulceration

1987 • 58 citations

7-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist

1989 • 53 citations

Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy

1992 • 47 citations

Gastric mucosal lesions induced by hemorrhagic shock in baboons

1988 • 36 citations

Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions

1989 • 24 citations

Reaction of methylated urates with 1,1diphenyl-2-picrylhydrazyl

1987 • 19 citations

Inhibition by REV-5901 of leukotriene release from guinea-pig and human lung tissue in vitro

1989 • 19 citations

Ethanol-induced gastric injury

1991 • 19 citations

REV 5901 and Ly 171,883 protect rat gastric mucosa against ethanol-induced damage

1987 • 17 citations

Possible existence of leukotriene D₄receptors and mechanism of their signal transduction in human polymorphonuclear leukocytes

1991 • 16 citations

Multiple actions of the leukotriene B4 receptor antagonist SC-41930.

1992 • 15 citations

Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production

1991 • 14 citations

Role of leukotrienes in hydrochloric acid-induced gastric lesions in rats

1990 • 14 citations

Aspirin-like drugs, ethanol-induced rat gastric injury and mueosal eicosanoid release

1991 • 13 citations

Comparison of the damage-promoting effects of leukotrienes derived from eicosapentaenoic acid and arachidonic acid on the rat stomach.

1990 • 12 citations

Down-regulation of receptor antigen in leukotriene B4-induced chemotactic deactivation of human polymorphonuclear leucocytes.

1991 • 12 citations

Mechanisms underlying the protective effects of interleukin-1 in experimental NSAID-gastropathy.

1992 • 11 citations

Role of Leukotrienes in Gastric Mucosal Damage and Protection

1988 • 5 citations

Leukotriene receptor blockade reduces bile acid-induced superficial gastric mucosal injury

1991 • 4 citations

Cited By (0)

Loading...