Na+/H+ exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

1992 • 585 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

The role of membrane receptors for C3b and C3d in phagocytosis.

1977 • 536 citations

Growth Factors Induce Phosphorylation of the Na ⁺ /H ⁺ Antiporter, a Glycoprotein of 110 kD

1990 • 452 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.

1994 • 332 citations

The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites.

1994 • 305 citations

The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

1992 • 291 citations

INHIBITION OF PHAGOCYTOSIS AND PLASMA MEMBRANE MOBILITY OF THE CULTIVATED MACROPHAGE BY CYTOCHALASIN B

1974 • 289 citations

Transport of H+ and of ionic weak acids and bases

1983 • 271 citations

Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger

1993 • 267 citations

Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.

1994 • 257 citations

Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective.

1994 • 247 citations

Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.

1993 • 245 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

1992 • 223 citations

Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger

1993 • 221 citations

Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2)

1993 • 215 citations

Isolation and characterization of gelatinase granules from human neutrophils

1994 • 201 citations

Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fc gamma receptor III on human neutrophils. Possible role of lectin-like interactions.

1993 • 192 citations

The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis.

1989 • 191 citations

Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

1991 • 178 citations

Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.

1992 • 175 citations

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

1994 • 167 citations

Signaling properties of CR3 (CD11b/CD18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles.

1993 • 166 citations

Potentiation of the oxidative burst of human neutrophils. A signaling role for L-selectin

1994 • 163 citations

Multiple integrins share the ability to induce elevation of intracellular pH*1

1991 • 161 citations

Intracellular pH modulates the generation of superoxide radicals by human neutrophils.

1985 • 156 citations

Regulation of intracellular pH in human neutrophils.

1985 • 152 citations

Activation of the Neutrophil (Part 1 of 4)

1988 • 149 citations

Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst.

1990 • 142 citations

Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.

1992 • 141 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

1984 • 135 citations

Calcium signaling capacity of the integrin on human neutrophils

1991 • 135 citations

Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates

1993 • 132 citations

Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts.

1989 • 131 citations

Differences in the ingestion mechanisms of IgG and C3b particles in phagocytosis by neutrophils.

1982 • 129 citations

Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase

1990 • 129 citations

KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA‐1‐ and CR3‐dependent adhesion

1993 • 127 citations

Inhibition of chemotactic factor-activated Na+/H+ exchange in human neutrophils by analogues of amiloride: structure-activity relationships in the amiloride series.

1986 • 113 citations

Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation

1992 • 110 citations

Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.

1991 • 106 citations

Characterization of receptor-mediated and store-regulated Ca2+ influx in human neutrophils

1994 • 94 citations

Cytoplasmic pH regulation in normal and abnormal neutrophils. Role of superoxide generation and Na+/H+ exchange.

1986 • 93 citations

Lectin-like inhibition of immune complex receptor-mediated stimulation of neutrophils. Effects on cytosolic calcium release and superoxide production.

1993 • 90 citations

Characterization of the amiloride-sensitive Na+-H+ antiport of human neutrophils

1986 • 89 citations

Immune complex-stimulated neutrophil LTB4 production is dependent on beta 2 integrins.

1993 • 88 citations

Natural killer cell and granulocyte Fc gamma receptor III (CD16) differ in membrane anchor and signal transduction.

1989 • 86 citations

Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate.

1992 • 82 citations

Two mechanisms for IgG Fc-receptor-mediated phagocytosis by human neutrophils.

1991 • 73 citations

Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3)

1991 • 72 citations

Evidence for the involvement of tyrosine kinases in the locomotory responses of human neutrophils

1992 • 69 citations

Volume changes in activated human neutrophils: The role of Na⁺/H⁺ exchange

1986 • 67 citations

Fc receptor-mediated signal transduction

1994 • 64 citations

Chemotactic factor-induced activation of Na+/H+ exchange in human neutrophils. I. Sodium fluxes.

1985 • 56 citations

Monoclonal antibody to human IgG Fc receptors. Cross-linking of receptors induces lysosomal enzyme release and superoxide generation by neutrophils.

1988 • 54 citations

Differential roles of Fc gamma RII and Fc gamma RIII in immune complex stimulation of human neutrophils.

1992 • 47 citations

The role of cyclic AMP, calcium and filamentous actin in adenosine modulation of Fc receptor-mediated phagocytosis in human neutrophils

1994 • 47 citations

Tyrosine phosphorylation and intracellular alkalinization are early events in human neutrophils stimulated by tumor necrosis factor, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor

1993 • 46 citations

Evidence for cross-regulation of Fc gamma RIIIB (CD16) receptor-mediated signaling by Fc gamma RII (CD32) expressed on polymorphonuclear neutrophils.

1992 • 45 citations

Tyrosine Phosphorylation of Phospholipase C-γ2 Is Involved in the Activation of Phosphoinositide Hydrolysis by Fc Receptors in Human Neutrophils

1994 • 42 citations

Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein.

1987 • 42 citations

Neutrophils increase volume during migration in vivo and in vitro.

1994 • 37 citations

Isolation of Full-Length RNA Templates for Reverse Transcription from Tissues Rich in RNase and Proteoglycans

1993 • 37 citations

Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.

1994 • 35 citations

Cytoplasmic pH regulation in activated human neutrophils: Effects of adenosine and pertussis toxin on Na+H+ exchange and metabolic acidification

1986 • 33 citations

Okadaic acid‐induced actin assembly in neutrophils: Role of protein phosphatases

1993 • 30 citations

Brush-border tyrosine phosphorylation stimulates ileal neutral NaCl absorption and brush-border Na(+)-H+ exchange

1994 • 29 citations

In Human Neutrophils the Binding to Immunocomplexes Induces the Tyrosine Phosphorylation of FcγRII But This Phosphorylation Is Not an Essential Signal for Fc-Mediated Phagocytosis

1994 • 20 citations

Receptor-mediated actin assembly in electropermeabilized neutrophils: Role of intracellular pH

1989 • 18 citations

Phosphorylation of Na(+)-H+ antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells

1993 • 18 citations

Isolation and characterization of platelet membranes prepared by free flow electrophoresis

1992 • 17 citations

Chapter 10 Regulation and Functional Significance of Cytoplasmic pH in Phagocytic Leukocytes

1990 • 17 citations

Formation of Inositol (1,4,5) Trisphosphate and Increase of Cytosolic Ca2+ Mediated by Fc Receptors in Human Neutrophils

1993 • 11 citations