Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

1977 • 777 citations

DNA Gyrase and the Supercoiling of DNA

1980 • 713 citations

Energy coupling in DNA gyrase and the mechanism of action of novobiocin

1978 • 403 citations

Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

1985 • 367 citations

Inhibitors of DNA topoisomerases

1988 • 340 citations

A Sign Inversion Mechanism for Enzymatic Supercoiling of DNA

1979 • 325 citations

Calculation of the Relative Change in Binding Free Energy of a Protein-Inhibitor Complex

1987 • 317 citations

DNA gyrase: subunit structure and ATPase activity of the purified enzyme.

1978 • 282 citations

Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli

1986 • 281 citations

Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity

1978 • 250 citations

Mechanism of quinolone inhibition of DNA gyrase

1989 • 215 citations

Mapping the active site tyrosine of Escherichia coli DNA gyrase.

1987 • 207 citations

Site-specific cleavage of DNA by E. coli DNA gyrase

1979 • 205 citations

DNA gyrase on the bacterial chromosome: DNA cleavage induced by oxolinic acid

1979 • 204 citations

Nucleotide sequence and gene organization of ColE1 DNA.

1985 • 201 citations

Evaluation of Intrinsic Binding Energy from a Hydrogen Bonding Group in an Enzyme Inhibitor

1987 • 174 citations

Mapping the topography of DNA wrapped around gyrase by nucleolytic and chemical probing of complexes of unique DNA sequences

1981 • 171 citations

The DNA dependence of the ATPase activity of DNA gyrase.

1984 • 159 citations

Site-specific interaction of DNA gyrase with DNA.

1981 • 153 citations

Structures of Two Thermolysin-Inhibitor Complexes That Differ by a Single Hydrogen Bond

1987 • 144 citations

The interaction of nucleosides in aqueous solution

1968 • 141 citations

Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli

1986 • 121 citations

Sites of reaction of Escherichia coli DNA gyrase on pBR322 in vivo as revealed by oxolinic acid-induced plasmid linearization

1985 • 117 citations

DNA gyrase and its complexes with DNA: direct observation by electron microscopy

1985 • 113 citations

Interaction between DNA gyrase and its cleavage site on DNA.

1980 • 96 citations

Inhibition of Micrococcus luteus DNA gyrase by norfloxacin and 10 other quinolone carboxylic acids

1986 • 87 citations

New nalidixic acid resistance mutations related to deoxyribonucleic acid gyrase activity

1981 • 82 citations

DNA gyrase on the bacterial chromosome: possibility of two levels of action.

1980 • 76 citations

Studies on the interaction of 4-quinolones with DNA by DNA unwinding experiments

1988 • 73 citations

Structure of the DNA gyrase-DNA complex as revealed by transient electric dichroism

1987 • 72 citations

DNA gyrase complex with DNA: determinants for site-specific DNA breakage.

1986 • 55 citations

Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents

1987 • 42 citations

Mapping of DNA gyrase cleavage sites in vivo oxolinic acid induced cleavages in plasmid pBR322

1985 • 40 citations

Refinement of the structure of nalidixic acid

1980 • 29 citations

Chapter 12 Quinolones

1987 • 25 citations

Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

1986 • 25 citations

Discrepancy between the Antibacterial Activities and the Inhibitory Effects on <i>Micrococcus luteus</i> DNA Gyrase of 13 Quinolones

1986 • 19 citations

Chapter 11. Antibacterial Agents

1984 • 1 citations

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