Chapter 12 Quinolones

The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro

1985 • 694 citations

The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans

1985 • 410 citations

Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

1985 • 367 citations

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

1986 • 261 citations

Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts

1986 • 188 citations

Comparative in vitro activities of ciprofloxacin and other 4-quinolones against Mycobacterium tuberculosis and Mycobacterium intracellulare

1986 • 129 citations

A yeast excision-repair gene is inducible by DNA damaging agents.

1986 • 125 citations

The mode of action of 4-quinolones and possible mechanisms of resistance

1986 • 123 citations

In vitro activity of Ro 23-6240, a new fluorinated 4-quinolone

1986 • 121 citations

Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli

1986 • 121 citations

Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents

1986 • 112 citations

Lack of emergence of resistant fecal flora during successful prophylaxis of traveler's diarrhea with norfloxacin

1986 • 94 citations

Evaluation of the in vitro bactericidal action of ciprofloxacin on cells of Escherichia coli in the logarithmic and stationary phases of growth

1985 • 85 citations

Pharmacokinetics of ciprofloxacin and effect of repeated dosage on salivary and fecal microflora

1986 • 82 citations

In vitro and in vivo antibacterial activity of AM-833, a new quinolone derivative

1986 • 78 citations

Emergence of Resistance to -Lactams, Aminoglycosides, and Quinolones During Combination Therapy for Infection Due to Serratia marcescens

1986 • 69 citations

Comparison of norfloxacin and nalidixic acid for treatment of dysentery caused by Shigella dysenteriae type 1 in adults

1986 • 68 citations

Use of ciprofloxacin in the treatment ofPseudomonas aeruginosa infections

1986 • 65 citations

Ciprofloxacin therapy for Mediterranean spotted fever

1986 • 64 citations

Pharmacokinetics of pefloxacin after repeated intravenous and oral administration (400 mg bid) in young healthy volunteers

1986 • 63 citations

In vitro comparison of A-56619, A-56620, amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin against methicillin-resistant Staphylococcus aureus

1986 • 61 citations

In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones

1986 • 57 citations

Difloxacin metabolism and pharmacokinetics in humans after single oral doses

1986 • 55 citations

Effects of norfloxacin on DNA metabolism in Pseudomonas aeruginosa

1986 • 54 citations

Pharmacokinetics of oral ciprofloxacin, 100 mg single dose, in volunteers and elderly patients

1986 • 54 citations

Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents

1986 • 53 citations

In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620

1985 • 53 citations

Pharmacokinetics of ofloxacin and theophylline alone and in combination

1986 • 53 citations

Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibacterial agents

1986 • 53 citations

Evaluation of ciprofloxacin in the treatment ofPseudomonas aeruginosa infections

1986 • 53 citations

In vitro susceptibility of Rickettsia conorii to ciprofloxacin as determined by suppressing lethality in chicken embryos and by plaque assay

1986 • 49 citations

Synergy of ciprofloxacin and azlocillin in vitro and in a neutropenic mouse model of infection

1986 • 46 citations

Pharmacokinetics of single-dose oral ciprofloxacin in patients undergoing chronic ambulatory peritoneal dialysis

1986 • 44 citations

Comparative trial of single-dose ciprofloxacin and ampicillin plus probenecid for treatment of gonococcal urethritis in men

1986 • 41 citations

Quinolones and colonization resistance in human volunteers

1986 • 35 citations

Chapter 15. Quinolone Antibacterial Agents

1985 • 34 citations

Pharmacokinetics of a new quinolone, AM-833, in mice, rats, rabbits, dogs, and monkeys

1986 • 34 citations

In vitro evaluation of A-56619 and A-56620, two new quinolones

1986 • 34 citations

In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones

1986 • 33 citations

Influence of pH and human urine on the antibacterial activity of ciprofloxacin, norfloxacin and ofloxacin.

1985 • 33 citations

Norfloxacin in the therapy of uncomplicated gonorrhea

1986 • 33 citations

A new synthesis of 7H-pyrido(1,2,3-de)(1,4)benzoxazine derivatives including an antibacterial agent, ofloxacin.

1986 • 30 citations

Evaluation of pefloxacin in experimental Escherichia coli meningitis

1986 • 29 citations

Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human γ-interferon production and blastogenesis

1986 • 26 citations

Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

1986 • 25 citations

Chapter 14. Quinolone Antibacterial Agents

1986 • 25 citations

Single and multiple dose pharmacokinetics of ciprofloxacin

1986 • 24 citations

In vitro activity of difloxacin hydrochloride (A-56619), A-56620, and cefixime (CL 284,635; FK 027) against selected genital pathogens

1986 • 24 citations

Pharmacokinetics and tolerance of enoxacin in healthy volunteers administered at a dosage of 400 mg twice daily for 14 days

1984 • 18 citations

Aryl-fluoroquinolone derivatives A-56619 (difloxacin) and A-56620 inhibit mitogen-induced human mononuclear cell proliferation

1986 • 18 citations

In vitro studies of S-25930 and S-25932, two new 4-quinolones

1986 • 7 citations

In vitro activity of CI-934, a new quinolone antimicrobial, against gram-positive bacteria

1986 • 6 citations

Irloxafin

1986 • 3 citations

CI-934

1986 • 3 citations

Gyrase inhibitors and intracellular DNA supercoiling

1986 • 3 citations

Preface

1986 • 1 citations