Down-regulation of hepatic HMG-CoA reductase in mice by dietary cholesterol: Importance of the .DELTA.5 double bond and evidence that oxidation at C-3, C-5, C-6, or C-7 is not involved

Regulation of the mevalonate pathway

1990 • 5,282 citations

Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives

1972 • 1,814 citations

Rapid separation of lipid classes in high yield and purity using bonded phase columns.

1985 • 939 citations

Biological activities of oxysterols

1989 • 355 citations

Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.

1984 • 312 citations

7α-Hydroxylation of cholestanol by rat liver microsomes

1968 • 242 citations

Cholesterol Biosynthesis in Preparations of Liver from Normal, Fasting, X-irradiated, Cholesterol-fed, Triton, or Δ4-Cholesten-3-one-treated Rats

1959 • 203 citations

Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells.

1980 • 172 citations

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells

1989 • 161 citations

26-Hydroxycholesterol. Identification and quantitation in human serum.

1981 • 120 citations

Mechanism of Microbial Transformation of Cholesterol into Coprostanol

1971 • 112 citations

Oxysterol Regulators of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Liver

1989 • 107 citations

On the Mechanism of the Enzymatic Conversion of Cholest-5-ene-3beta,7alpha-diol into 7alpha-Hydroxycholest-4-en-3-one

1969 • 67 citations

3-hydroxy-3-methylglutaryl coenzyme A reductase in human liver microsomes: active and inactive forms and cross-reactivity with antibody against rat liver enzyme.

1984 • 58 citations

Stereospecific Syntheses of the 7-Deuterio- and 7-Tritiocholesterols. The Mechanism of Enzyme-catalyzed Hydroxylation at a Saturated Carbon Atom

1959 • 55 citations

The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1992 • 54 citations

Effect of vitamin D3 derivatives on cholesterol synthesis and HMG-CoA reductase activity in cultured cells.

1989 • 51 citations

Generation of Regulatory Oxysterols: 26-Hydroxylation of Cholesterol by Ovarian Mitochondria*

1990 • 51 citations

Evidence that 24- and 27-hydroxylation are not involved in the cholesterol-induced down-regulation of hydroxymethylglutaryl-CoA reductase in mouse liver.

1992 • 47 citations

On the mechanism of oxidation of cholesterol at C-7 in a lipoxygenase system.

1992 • 38 citations

Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl COA synthase and affinities for the oxysterol receptor

1992 • 34 citations

Comparison of the effects of some C27−, C21−, and C19-steroids upon hepatic sterol synthesis and hydroxymethylglutaryl—CoA reductase activity

1970 • 32 citations

Studies on the regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in rat liver: effects of lymphatic drainage and ligation of the lymph duct.

1990 • 29 citations

Biosynthesis of cholestanol: Conversion of cholesterol into 4-cholesten-3-one by rat liver microsomes

1974 • 27 citations

Inhibition of hepatic cholesterol synthesis in mice by sterols with shortened and stereochemically varied side chains.

1982 • 20 citations

Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.

1992 • 17 citations

On the structural specificity in the regulation of the hydroxymethylglutaryl-CoA reductase and the cholesterol-7α-hydroxylase in rats. Effects of cholestanol feeding

1985 • 16 citations