Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5

1982 • 936 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9

1979 • 494 citations

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol

1984 • 393 citations

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1985 • 384 citations

[75] Assay of transforming activity of tumor virus DNA

1980 • 331 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

1982 • 253 citations

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

1987 • 220 citations

The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene

1986 • 207 citations

Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.

1988 • 194 citations

5′ end of hmg CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription

1985 • 187 citations

The LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism

1976 • 183 citations

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

1987 • 180 citations

Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells.

1980 • 172 citations

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1988 • 171 citations

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

1988 • 165 citations

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.

1986 • 109 citations

Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency.

1986 • 97 citations

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

1981 • 93 citations

Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol, and serum.

1979 • 62 citations

Homologous ribosomal proteins in bacteria, yeast, and humans.

1986 • 60 citations

Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1988 • 50 citations

Revertants of a Chinese hamster ovary cell mutant resistant to suppression by an analog of cholesterol: isolation and partial biochemical characterization

1982 • 47 citations

15 Acyl Coenzyme A: Cholesterol O-Acyltransferase

1983 • 39 citations

Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters.

1987 • 37 citations

Somatic cell genetics and the study of cholesterol metabolism

1988 • 29 citations

Complementary recessive 25‐hydroxycholesterol‐resistant somatic cell mutants – assay of 25‐hydroxycholesterol binding activity

1982 • 19 citations