Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

Evolution of the P450 gene superfamily:

1990 • 508 citations

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

1987 • 320 citations

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

1990 • 200 citations

Human Cytochrome P450 2E1 Is a Major Autoantigen Associated with Halothane Hepatitis

1996 • 186 citations

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

1994 • 168 citations

A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis.

1984 • 166 citations

Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis.

1996 • 162 citations

Cytochromes P-450 in human hepatocyte plasma membrane: Recognition by several autoantibodies

1993 • 152 citations

Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells.

1993 • 134 citations

Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs

1994 • 126 citations

Ticrynafen-Associated Hepatic Injury: Analysis of 340 Cases

1984 • 125 citations

Mechanisms of halothane toxicity: Novel insights

1993 • 116 citations

Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane

1990 • 95 citations

Human‐liver cytochromes P‐450 expressed in yeast as tools for reactive‐metabolite formation studies

1993 • 90 citations

Role of reactive metabolites in drug-induced hepatitis

1995 • 89 citations

B-type cytochromes in plasma membranes isolated from rat liver, in comparison with those of endomembranes.

1979 • 88 citations

Autoantibodies against Cytochromes P450: Role in Human Diseases

1994 • 86 citations

Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies.

1994 • 85 citations

Distribution of enzymes involved in metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes.

1980 • 84 citations

Possible role of HLA in hepatotoxicity

1994 • 80 citations

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.

1996 • 76 citations

Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking.

1991 • 74 citations

Uncoupling of rat and human mitochondria: A possible explanation for tacrine-induced liver dysfunction

1996 • 70 citations

Presence of functionally active cytochrome P-450IIE1 in the plasma membrane of rat hepatocytes

1992 • 69 citations

The Cytoplasmic and N-terminal Transmembrane Domains of Cytochrome P450 Contain Independent Signals for Retention in the Endoplasmic Reticulum

1995 • 67 citations

Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes

1995 • 60 citations

Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations.

1993 • 56 citations

Membrane Topology of Liver Microsomal Cytochrome P450 2B4 Determined via Monoclonal Antibodies Directed to the Halt-Transfer Signal

1994 • 39 citations

Cytochrome P450IID6 recognized by LKMl antibody is not exposed on the surface of hepatocytes

1993 • 33 citations

Liver cell surface expression of the antigen reacting with liver-kidney microsomal antibody (LKM).

1984 • 32 citations

Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11.

1991 • 26 citations

Anti-liver-kidney microsome antibody is a marker for the rat hepatocyte endoplasmic reticulum

1987 • 20 citations

Lack of surface expression for the B-cell autoepitope of cytochrome P450 IID6 evidenced by flow cytometry.

1993 • 15 citations

Mécanisme des hépatites immunoallergiques induites par l'acied tiénilique : Activation métabolique de ce médicament et fixation covalente sur les cytochromes P4502C chez l'homme et le rat

1996 • 2 citations

La clathrine est-elle superflue pour l'endocytose non spécifique ?

1995 • 1 citations