Membrane Topology of Liver Microsomal Cytochrome P450 2B4 Determined via Monoclonal Antibodies Directed to the Halt-Transfer Signal

Basic local alignment search tool

1990 • 87,358 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Membrane protein folding and oligomerization: the two-stage model

1990 • 927 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

Cytochrome P-450

1986 • 734 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Transport of Proteins Across the Endoplasmic Reticulum Membrane

1992 • 366 citations

On the membrane topology of vertebrate cytochrome P-450 proteins.

1988 • 362 citations

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.

1992 • 180 citations

Structural features of liver microsomal NADPH-cytochrome P-450 reductase. Hydrophobic domain, hydrophilic domain, and connecting region.

1982 • 173 citations

Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies.

1987 • 160 citations

Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane.

1988 • 151 citations

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

1983 • 146 citations

Membrane topology of the mammalian P450 cytochromes

1992 • 139 citations

Structure of cytochrome b5 and its topology in the microsomal membrane

1989 • 117 citations

Systematic analysis of stop-transfer sequence for microsomal membrane

1991 • 112 citations

Polypeptide translocation across the endoplasmic reticulum membrane.

1992 • 95 citations

Isolation, Properties, and the Complete Amino Acid Sequence of a Second Form of 60-kDa Glycoprotein Esterase

1989 • 91 citations

Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes.

1993 • 90 citations

An investigation of the transverse topology of bilirubin UDP-glucuronosyltransferase in rat hepatic endoplasmic reticulum

1989 • 87 citations

The expression of a catalytically active cholesterol 7 alpha-hydroxylase cytochrome P450 in Escherichia coli.

1991 • 81 citations

Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum

1989 • 75 citations

Forces involved in the assembly and stabilization of membrane proteins ¹

1992 • 71 citations

The hydrophobic amino-terminal sequence of bovine 17 alpha-hydroxylase is required for the expression of a functional hemoprotein in COS 1 cells.

1991 • 71 citations

Protein transport across the endoplasmic reticulum membrane: facts, models, mysteries

1991 • 66 citations

Functional characterization of flavin-containing monooxygenase 1B1 expressed in Saccharomyces cerevisiae and Escherichia coli and analysis of proposed FAD- and membrane-binding domains.

1993 • 60 citations

An N-terminal glycosylation signal on cytochrome P450 is restricted to the endoplasmic reticulum in a luminal orientation.

1993 • 54 citations

Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family

1992 • 52 citations

Spontaneous insertion of polypeptide chains into membranes: a Monte Carlo model.

1992 • 48 citations

Domains of Rat Heme Oxygenase-2: The Amino Terminus and Histidine 151 Are Required for Heme Oxidation

1993 • 45 citations

The N-terminal hydrophobic domain of P450c21 is required for membrane insertion and enzyme stability

1993 • 32 citations

Localization of the N-terminal methionine of rat liver cytochrome P-450 in the lumen of the endoplasmic reticulum

1991 • 25 citations

Membrane topology of epoxide hydrolase

1990 • 24 citations

Simple modifications of a protein immunoblotting protocol to reduce nonspecific background.

1992 • 23 citations

Rat liver polysome N.alpha.-acetyltransferase: substrate specificity

1991 • 20 citations

Two distinct sequences control the targeting and anchoring of the mouse P450 1A1 into the yeast endoplasmic reticulum membrane

1992 • 20 citations

Probing the membrane topology of Candida tropicalis cytochrome P450

1993 • 19 citations

Binding and fluorescence properties of the membrane domain of NADH-cytochrome-b5 reductase. Determination of the depth of Trp-16 in the bilayer.

1986 • 18 citations

Structural studies on bovine spleen heme oxygenase

1990 • 12 citations