Biomarkers to assess the genetic damage induced by alcohol abuse in human lymphocytes

Individual Comparisons by Ranking Methods

1945 • 12,649 citations

Use of Ranks in One-Criterion Variance Analysis

1952 • 9,960 citations

Use of Ranks in One-Criterion Variance Analysis

1952 • 2,201 citations

Measurement of micronuclei in lymphocytes

1985 • 1,807 citations

The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations

1993 • 990 citations

Identification of aneuploidy‐inducing agents using cytokinesis‐blocked human lymphocytes and an antikinetochore antibody

1989 • 645 citations

The HUman MicroNucleus Project—An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans

1999 • 609 citations

Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health.

2000 • 498 citations

Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage.

1994 • 493 citations

The role of folic acid and Vitamin B12 in genomic stability of human cells

2001 • 465 citations

HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei

2001 • 412 citations

Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults

1998 • 319 citations

Molecular and genetic damage in humans from environmental pollution in Poland

1992 • 276 citations

Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei.

1995 • 212 citations

Important variables that influence base-line micronucleus frequency in cytokinesis-blocked lymphocytes—a biomarker for DNA damage in human populations

1998 • 199 citations

DNA Damage, DNA Repair, and Alcohol Toxicity—A Review

1997 • 178 citations

Mouse lymphoma L5178Y thymidine kinase locus assay of 50 compounds

1988 • 161 citations

Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men

1997 • 159 citations

Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian population: II. Contribution of sex, age, and lifestyle

1998 • 144 citations

Alcohol consumption and risk of cancer in humans: An overview

1995 • 140 citations

Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status

2000 • 132 citations

Chromosomal damage and ageing: effect on micronuclei frequency in peripheral blood lymphocytes

1999 • 125 citations

Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect

1991 • 112 citations

Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation.

1995 • 112 citations

Biological and environmental monitoring of occupational exposure to cyclophosphamide in industry and hospitals

1988 • 111 citations

Genetic effects of ethanol

1987 • 109 citations

Alcohol and Cancer

1998 • 109 citations

Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health

1998 • 99 citations

Influence of sex on cytogenetic end points: evidence from a large human sample and review of the literature.

1995 • 93 citations

Human micronucleus counts are correlated with age, smoking, and cesium-137 dose in the Goiânia (Brazil) radiological accident

1994 • 90 citations

A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency

1996 • 88 citations

Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide

2008 • 87 citations

Age-Dependent Inclusion of Sex Chromosomes in Lymphocyte Micronuclei of Man

1998 • 82 citations

Is ethanol genotoxic? A review of the published data

2001 • 76 citations

Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method

1991 • 75 citations

Chromosomal aberrations in peripheral lymphocytes of alcoholics

1980 • 75 citations

Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women

1995 • 75 citations

Micronucleus assay in lymphocytes as a tool to biomonitor human exposure to aneuploidogens and clastogens.

1993 • 75 citations

Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.

1996 • 73 citations

Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics

2000 • 69 citations

Cytogenetic biomonitoring in traffic police workers: Micronucleus test in peripheral blood lymphocytes

1997 • 67 citations

Biomarkers and molecular epidemiology in mutation/cancer research

1994 • 61 citations

No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

1996 • 58 citations

Detection of the centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocyte micronucleus assay after treatment with four suspected aneugens

1996 • 58 citations

Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition

1987 • 54 citations

Acetaldehyde‐induced mutation at the hprt Locus in Human Lymphocytes In Vitro

1990 • 54 citations

Influence of smoking habits on the frequencies of structural and numerical chromosomal aberrations in human peripheral blood lymphocytes using the fluorescence in Situ hybridization (FISH) technique

1995 • 51 citations

The frequency of micronuclei with X chromosome increases with age in human females

1994 • 51 citations

Increased frequency of sister-chromatid exchanges in alcoholics

1981 • 50 citations

Indicators of genetic damage in alcoholics: reversibility after alcohol abstinence.

1999 • 49 citations

Chromosomal aberrations in peripheral lymphocytes from healthy subjects as detected in first cell division

1999 • 45 citations

Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay

1983 • 43 citations

Socio-Economic Changes and Nutrition in Japan After World War II

1975 • 43 citations

Chromosome aberrations in peripheral blood lymphocytes from control individuals

1995 • 36 citations

Chromosomal aberrations in lymphocytes from car painters

1996 • 30 citations

DNA-repair capacity and lipid peroxidation in chronic alcoholics

1991 • 25 citations

Analysis of chromosomal aberration frequencies in the peripheral blood lymphocytes of smokers exposed to uranyl compounds

2000 • 24 citations

A Follow‐Up Study on Chromosomal Aberrations in Lymphocytes of Alcoholics During Early, Medium, and Long‐Term Abstinence

1999 • 20 citations

Sister chromatid exchanges in lymphocytes of normal and alcoholic subjects

1992 • 17 citations

Epidemiology and pathophysiology of ethanol-associated gastrointestinal cancer

1992 • 13 citations

Chromosomal Aberrations in the Lymphocytes of Alcoholics and Former Alcoholics

1987 • 11 citations

Factors affecting various biomarkers inuntreated lung cancer patients and healthy donors

1997 • 10 citations

Chromosomal aberrations & sister chromatid exchanges in chronic male alcoholics.

1986 • 8 citations

Chromosomal Aberrations in Peripheral Lymphocytes of Abstinent Alcoholics

1997 • 7 citations

Defective Calcium Increase and Inositol Phosphate Production in Anti‐CD₃‐Stimulated Lymphocytes of Alcoholics without Progressive Liver Disease

1996 • 7 citations

Joseph W. Cullen Memorial Award Lecture. Paving the road from basic research to policy: cigarette smoking as a prototype issue for cancer control science.

1992 • 5 citations