Quantitation of hepatic hepatitis C virus RNA in patients with chronic hepatitis C. Relationship with severity of disease, viral genotype and response to treatment

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Avoiding false positives with PCR

1989 • 3,564 citations

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Detection of hepatitis C virus by polymerase chain reaction and response to interferon-α therapy: Relationship to genotypes of hepatitis C virus

1992 • 689 citations

Epidemiology of Hepatitis C in the West

1995 • 506 citations

Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

1995 • 474 citations

Factors predictive of response to interferon-α therapy in hepatitis C virus infection

1994 • 444 citations

Specific detection of hepatitis C virus minus strand RNA in hematopoietic cells.

1996 • 273 citations

Quantification of hepatitis C virus by competitive reverse transcription—polymerase chain reaction: Increase of the virus in advanced liver disease

1993 • 257 citations

Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C

1994 • 234 citations

Effect of interferon alfa on the dynamics of hepatitis C virus turnoverin vivo

1996 • 230 citations

Assessment of Hepatitis C Virus RNA Levels by Quantitative Competitive RNA Polymerase Chain Reaction: High-Titer Viremia Correlates with Advanced Stage of Disease

1994 • 219 citations

Detection of replicative intermediates of hepatitis C viral RNA in liver and serum of patients with chronic hepatitis C.

1991 • 207 citations

Persistent hepatitis C viraemia without liver disease

1993 • 199 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients.

1994 • 193 citations

The natural course of chronic hepatitis C: A comparison between patients with genotypes 1 and 2 hepatitis C viruses

1996 • 193 citations

Serum hepatitis C virus RNA quantity and histological features of hepatitis C virus carriers with persistently normal ALT levels

1994 • 169 citations

The natural course of chronic hepatitis C: A comparison between patients with genotypes 1 and 2 hepatitis C viruses

1996 • 156 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: Definition of optimal conditions for specimen collection and clinical application in interferon-treated patients

1994 • 150 citations

Classification of hepatitis C viruses based on phylogenetic analysis of the envelope 1 and nonstructural 5B regions and identification of five additional subtypes.

1994 • 146 citations

Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C

1996 • 125 citations

Long-term longitudinal study of intrahepatic hepatitis C virus replication after liver transplantation

1997 • 104 citations

Hepatic Hepatitis C Virus RNA as a Predictor of a Long-Term Response to Interferon-α Therapy

1995 • 96 citations

Factors predictive of the response to interferon in patients with chronic hepatitis C

1994 • 91 citations

Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease

1994 • 87 citations

Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection

1997 • 87 citations

Hepatic and extrahepatic hepatitis C virus replication in relation to response to interferon therapy

1994 • 86 citations

Hepatic and extrahepatic HCV RNA strands in chronic hepatitis C: Different patterns of response to interferon treatment

1993 • 73 citations

Distribution of Hepatitis C Virus (HCV) RNA in Whole Blood and Blood Cell Fractions: Plasma HCV RNA Analysis Underestimates Circulating Virus Load

1997 • 70 citations

Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo

1996 • 68 citations

Hepatitis C Virus (HCV) Viremia in Human Immunodeficiency VirusSeronegative and -Seropositive Patients with Indeterminate HCV Recombinant Immunoblot Assay

1994 • 66 citations

Hepatitis C RNA in liver of chronic hepatitis C patients before and after interferon alfa treatment

1993 • 65 citations

Predictors of a sustained beneficial response to interferon alfa therapy in chronic hepatitis C

1995 • 53 citations

Eradication of Hepatitis C Virus RNA after Alpha-Interferon Therapy

1994 • 50 citations

Detection and quantification of hepatitis C virus RNA replication in the liver

1994 • 43 citations

Predictors of a sustained beneficial response to interferon alfa therapy in chronic hepatitis C

1995 • 38 citations

Quantitative detection of hepatitis C virus genome in liver tissue and circulation by competitive reverse transcription-polymerase chain reaction

1994 • 38 citations

Quantitative liver parameters of HCV infection: relation to HCV genotypes, viremia and response to interferon treatment

1997 • 33 citations

Quantitative analysis of hepatitis C virus RNA in liver biopsies by competitive reverse transcription and polymerase chain reaction

1995 • 27 citations

Quantitation of hepatitis C viral RNA in liver and serum samples using competitive polymerase chain reaction.

1995 • 25 citations

Correlation between the serum level of hepatitis C virus RNA and disease activities in acute and chronic hepatitis C

1992 • 25 citations

Detection and typing of hepatitis C RNA in liver biopsies and its relation to histopathology

1996 • 13 citations

Hepatic HCV‐RNA as a predictor of outcome after interferon therapy in patients with chronic hepatitis C

1996 • 10 citations

Quantitation of hepatitis C virus RNA in liver tissue as a predictive marker of the response to interferon therapy in chronic hepatitis C.

1994 • 7 citations

Correlation between serum and liver tissue HCV-RNA levels in patients with chronic hepatitis C

1995 • 6 citations

Lymphoblastoid interferon improves long-term response to a six month course of treatment when compared with recombinant interferon alpha 2b: Results of an international trial St. Louis U, U Sidney, Australia, Hospital Beaujon, Clichy, France, Virchow-Klinikum, Berlin, Hospital Ramon y Cajal, Madrid, Mt. Sinai Hospital, Toronto, Ospedale Molinette, Turin, Italy, UCSF, Burroughs Wellcome Co.

1995 • 4 citations