The Gene Encoding Fibrinogen-β Is a Target for Retinoic Acid Receptor-Related Orphan Receptor α

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Orphan Nuclear Receptors: From Gene to Function*

1999 • 789 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

Disruption of the nuclear hormone receptor RORα in staggerer mice

1996 • 478 citations

Transcription factors in liver development, differentiation, and regeneration

2003 • 398 citations

Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.

1988 • 323 citations

IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.

1989 • 307 citations

Fibrin(ogen) in cardiovascular disease: an update

2003 • 286 citations

Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion.

1985 • 268 citations

The orphan nuclear receptor RORα is a negative regulator of the inflammatory response

2001 • 265 citations

Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif Sequences

1993 • 252 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

1994 • 242 citations

The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat

1995 • 204 citations

The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element

1993 • 199 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

1994 • 194 citations

Regional variation and absence of large neurons in the cerebellum of the staggerer mouse

1979 • 189 citations

Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome 1 1Edited by M. Gottesman

1997 • 180 citations

Severe Atherosclerosis and Hypoalphalipoproteinemia in the Staggerer Mouse, a Mutant of the Nuclear Receptor RORα

1998 • 172 citations

Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β

2001 • 155 citations

RORα Coordinates Reciprocal Signaling in Cerebellar Development through Sonic hedgehog and Calcium-Dependent Pathways

2003 • 149 citations

The Human β Fibrinogen Promoter Contains a Hepatocyte Nuclear Factor 1-Dependent Interleukin-6-Responsive Element

1993 • 149 citations

Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a

2002 • 143 citations

Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-

1999 • 137 citations

Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORα

2001 • 137 citations

Regulation of fibrinogen assembly. Transfection of Hep G2 cells with B beta cDNA specifically enhances synthesis of the three component chains of fibrinogen.

1990 • 134 citations

Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation

1999 • 130 citations

Transcriptional Regulation of Apolipoprotein A-I Gene Expression by the Nuclear Receptor RORα

1997 • 129 citations

Determinants of Target Gene Specificity for RORα1: Monomeric DNA Binding by an Orphan Nuclear Receptor

1995 • 121 citations

The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.

1993 • 117 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers

1994 • 116 citations

In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism

2000 • 115 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator.

1994 • 109 citations

Characterization of the IL-6 Responsive Elements in the γ Fibrinogen Gene Promoter

1995 • 103 citations

Intracellular assembly of human fibrinogen.

1983 • 103 citations

Human beta-fibrinogen gene expression. Upstream sequences involved in its tissue specific expression and its dexamethasone and interleukin 6 stimulation.

1990 • 96 citations

Transcriptional Activation and Repression by RORα, an Orphan Nuclear Receptor Required for Cerebellar Development

1997 • 95 citations

The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element.

1993 • 94 citations

Targeted Ablation of the Murine Involucrin Gene

2000 • 85 citations

Evidence for a Hyperexcitability State of Staggerer Mutant Mice Macrophages

1992 • 79 citations

The Structural Integrity of RORα Isoforms Is Mutated instaggererMice: Cerebellar Coexpression of RORα1 and RORα4

1997 • 75 citations

Cerebellar purkinje cell loss during life span of the heterozygousStaggerer mouse (Rora+/Rorasg) is gender-related

1999 • 75 citations

Differential Regulation of the N-myc Proto-Oncogene by RORα and RVR, Two Orphan Members of the Superfamily of Nuclear Hormone Receptors

1997 • 69 citations

Transcriptional Regulation of Human Rev-erbα Gene Expression by the Orphan Nuclear Receptor Retinoic Acid-related Orphan Receptor α

2002 • 67 citations

Transcription factors in liver development, differentiation, and regeneration

2003 • 66 citations

Characterization of the 5′-Flanking Region of the Gene for the α Chain of Human Fibrinogen

1995 • 59 citations

Detection of a Novel Transcription Factor for the Aα Fibrinogen Gene in Response to Interleukin-6

1995 • 53 citations

Functional characterization of promoter elements involved in regulation of human B beta-fibrinogen expression. Evidence for binding of novel activator and repressor proteins.

1993 • 49 citations

Characterization of the 5′-Flanking Region of the Gene for the γChain of Human Fibrinogen

1995 • 49 citations

Retinoic acid receptor-related orphan receptor (ROR) α4 is the predominant isoform of the nuclear receptor RORα in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells

2002 • 48 citations

Increased Ischemia-Induced Angiogenesis in the Staggerer Mouse, a Mutant of the Nuclear Receptor Rorα

2001 • 43 citations

Transcriptional regulation of a Purkinje cell‐specific gene through a functional interaction between RORα and RAR

1997 • 41 citations

Chromosomal localization of human and rat Aα, Bβ, and γ fibrinogen genes by in situ hybridization

1986 • 37 citations

Modulation of the Far-Upstream Enhancer of the Rat α-Fetoprotein Gene by Members of the RORα, Rev-erbα, and Rev-erbβ Groups of Monomeric Orphan Nuclear Receptors

2000 • 37 citations

The c- jun Proto-oncogene Down-regulates the Rat α-Fetoprotein Promoter in HepG2 Hepatoma Cells without Binding to DNA

1995 • 31 citations

Two-peaked Synchronization in Day/Night Expression Rhythms of the Fibrinogen Gene Cluster in the Mouse Liver

2003 • 21 citations

Influences of lipid-modifying agents on hemostasis

1993 • 19 citations

Differential binding and transcriptional behaviour of two highly related orphan receptors, RORα4 and RORβ1

2000 • 10 citations

Fibrinogen determination by five methods in patients receiving streptokinase therapy

1990 • 6 citations