Retinoic acid receptor-related orphan receptor (ROR) α4 is the predominant isoform of the nuclear receptor RORα in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

Disruption of the nuclear hormone receptor RORα in staggerer mice

1996 • 478 citations

Mammalian Oxygen Sensing, Signalling and Gene Regulation

2000 • 453 citations

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

1994 • 449 citations

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

1990 • 410 citations

Oxygen: Modulator of metabolic zonation and disease of the liver

2000 • 410 citations

Glucocorticoid-induced DNA demethylation and gene memory during development

2001 • 304 citations

staggerer phenotype in retinoid-related orphan receptor α-deficient mice

1998 • 272 citations

The orphan nuclear receptor RORα is a negative regulator of the inflammatory response

2001 • 265 citations

Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif Sequences

1993 • 252 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

1994 • 242 citations

The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes

2001 • 227 citations

Hypoxia-Inducible Factor 1-Mediated Inhibition of Peroxisome Proliferator-Activated Receptor α Expression During Hypoxia

2001 • 216 citations

Hypoxia-inducible Protein Binding to Vascular Endothelial Growth Factor mRNA and Its Modulation by the von Hippel-Lindau Protein

1996 • 212 citations

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes

1993 • 206 citations

Hepatocellular Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Angiogenesis in Experimental Biliary Cirrhosis

1999 • 202 citations

The Orphan Receptor Hepatic Nuclear Factor 4 Functions as a Transcriptional Activator for Tissue-Specific and Hypoxia-Specific Erythropoietin Gene Expression and Is Antagonized by EAR3/COUP-TF1

1995 • 200 citations

Regional variation and absence of large neurons in the cerebellum of the staggerer mouse

1979 • 189 citations

Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture

1989 • 176 citations

Hypoxia Inhibits the Peroxisome Proliferator-activated Receptor α/ Retinoid X Receptor Gene Regulatory Pathway in Cardiac Myocytes

2001 • 175 citations

Severe Atherosclerosis and Hypoalphalipoproteinemia in the Staggerer Mouse, a Mutant of the Nuclear Receptor RORα

1998 • 172 citations

Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer

1998 • 171 citations

Hypoxia Regulates β-Enolase and Pyruvate Kinase-M Promoters by Modulating Sp1/Sp3 Binding to a Conserved GC Element

1998 • 167 citations

Hypoxia Induces Accumulation of p53 Protein, but Activation of a G₁-Phase Checkpoint by Low-Oxygen Conditions Is Independent of p53 Status

1994 • 144 citations

Transcriptional Regulation of Apolipoprotein C-III Gene Expression by the Orphan Nuclear Receptor RORα

2001 • 137 citations

Effects of Transition Metals on the Expression of the Erythropoietin Gene: Further Evidence That the Oxygen Sensor Is a Heme Protein

1996 • 134 citations

Transcriptional Regulation of Apolipoprotein A-I Gene Expression by the Nuclear Receptor RORα

1997 • 129 citations

Tumor Hypoxia and Gene Expression: Implications for Malignant Progression and Therapy

1998 • 122 citations

Determinants of Target Gene Specificity for RORα1: Monomeric DNA Binding by an Orphan Nuclear Receptor

1995 • 121 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers

1994 • 116 citations

In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism

2000 • 115 citations

Identification of Natural Monomeric Response Elements of the Nuclear Receptor RZR/ROR. THEY ALSO BIND COUP-TF HOMODIMERS

1996 • 104 citations

Exogenous expression of a dominant negative ROR 1 vector in muscle cells impairs differentiation: ROR 1 directly interacts with p300 and MyoD

1999 • 92 citations

The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions

1995 • 92 citations

Cerebellar purkinje cell loss during life span of the heterozygousStaggerer mouse (Rora+/Rorasg) is gender-related

1999 • 75 citations

The Structural Integrity of RORα Isoforms Is Mutated instaggererMice: Cerebellar Coexpression of RORα1 and RORα4

1997 • 75 citations

Activation of orphan receptor-mediated transcription by Ca2+/calmodulin-dependent protein kinase IV

2000 • 71 citations

Age-related phenotypes in the staggerer mouse expand the RORα nuclear receptor's role beyond the cerebellum

2002 • 71 citations

RORα Gene Expression in the Perinatal Rat Cerebellum: Ontogeny and Thyroid Hormone Regulation¹

1998 • 69 citations

Differential Regulation of the N-myc Proto-Oncogene by RORα and RVR, Two Orphan Members of the Superfamily of Nuclear Hormone Receptors

1997 • 69 citations

Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells.

1998 • 47 citations

The Metastasis Suppressor Candidate Nucleotide Diphosphate Kinase NM23 Specifically Interacts with Members of the ROR/RZR Nuclear Orphan Receptor Subfamily

1996 • 42 citations

Modulation of the Far-Upstream Enhancer of the Rat α-Fetoprotein Gene by Members of the RORα, Rev-erbα, and Rev-erbβ Groups of Monomeric Orphan Nuclear Receptors

2000 • 37 citations

The c- jun Proto-oncogene Down-regulates the Rat α-Fetoprotein Promoter in HepG2 Hepatoma Cells without Binding to DNA

1995 • 31 citations

Augmentation of Thyroid Hormone Receptor-Mediated Transcription by Ca2+/Calmodulin-Dependent Protein Kinase Type IV

2000 • 25 citations

Severe Hypoxia Specifically Downregulates Hepatocyte Nuclear Factor-4 Gene Expression in HepG2 Human Hepatoma Cells

2001 • 20 citations

Augmentation of Thyroid Hormone Receptor-Mediated Transcription by Ca2+/Calmodulin-Dependent Protein Kinase Type IV

2000 • 8 citations

Cerebellar purkinje cell loss during life span of the heterozygous Staggerer mouse (RoraRorasg) is gender‐related

1999 • 5 citations