Insulin modulation of pyruvate dehydrogenase in human circulating lymphocytes

Malignant Lymphomas Other than Hodgkin’s Disease

1978 • 871 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Nonspecific acid esterase activity: A criterion for differentation of T and B lymphocytes in mouse lymph nodes

1975 • 457 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

A defect in pyruvate decarboxylase in a child with an intermittent movement disorder

1970 • 253 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model.

1977 • 205 citations

Active and Inactive Forms of Pyruvate Dehydrogenase in Rat Liver

1972 • 199 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

Cellular phenotypes of normal and leukemic hemopoietic cells determined by analysis with selected antibody combinations

1980 • 167 citations

Studies on the Mechanism of Activation of Adipose Tissue Pyruvate Dehydrogenase by Insulin

1973 • 162 citations

Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man.

1975 • 160 citations

Interconversion and Kinetic Properties of Pyruvate Dehydrogenase from Brain

1971 • 127 citations

Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin.

1981 • 99 citations

Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.

1980 • 95 citations

Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.

1982 • 85 citations

Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin

1986 • 84 citations

Role of insulin in the intermediary metabolism of the activated thymic-derived lymphocyte.

1981 • 81 citations

Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes.

1979 • 80 citations

Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

1986 • 74 citations

Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase

1981 • 74 citations

Brain Pyruvate Dehydrogenase: Phosphorylation and Enzyme Activity Altered by a Training Experience

1981 • 68 citations

Isolation from Rat Adipocytes of a Chemical Mediator for Insulin Activation of Pyruvate Dehydrogenase

1980 • 61 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin

1984 • 60 citations

Insulin Mediators from Rat Skeletal Muscle Have Differential Effects on Insulin-Sensitive Pathways of Intact Adipocytes

1985 • 58 citations

Regulation by Insulin of Adipose Tissue Pyruvate Dehydrogenase. A Mechanism Controlling Fatty Acid Synthesis from Carbohydrates

1974 • 56 citations

Partial purification from hepatoma cells of an intracellular substance which mediates the effects of insulin on pyruvate dehydrogenase and low Km cyclic AMP phosphodiesterase

1982 • 46 citations

Insulin Mediators and Their Control of Metabolism through Protein Phosphorylation

1982 • 34 citations

Differences in the effect of insulin on the generation by adipocytes and IM-9 lymphocytes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase

1980 • 33 citations

Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase

1980 • 21 citations

Evidence of an insulin generated pyruvate dehydrogenase stimulating factor in rat brain plasma membranes

1987 • 20 citations

Lectins activate lymphocyte pyruvate dehydrogenase by a mechanism sensitive to protease inhibitors.

1981 • 16 citations

Effect of insulin on the pyruvate dehydrogenase complex in the rat brain.

1985 • 16 citations

Effect of insulin on pyruvate dehydrogenase in a mixture of plasma membranes and mitochondria from normal and alloxan treated rat brains

1986 • 12 citations

Effects of insulin on pyruvate dehydrogenase in circulating lymphocytes from normal and diabetic rats

1988 • 7 citations

Characterization of a pyruvate dehydrogenase modulator purified from insulin-treated rat brain plasma membranes.

1986 • 5 citations