Interleukin-6 inhibits bone formation in vitro

Interleukin-6: An Overview

1990 • 1,910 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats

1988 • 1,330 citations

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

1990 • 1,307 citations

IL-6 is produced by osteoblasts and induces bone resorption.

1990 • 1,121 citations

Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations

1986 • 855 citations

Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

1988 • 793 citations

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

1992 • 685 citations

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis

1989 • 376 citations

Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells

1988 • 286 citations

Perspectives: Interleukin-6: An osteotropic factor?

1992 • 283 citations

Determination of numbers of osteoprogenitors present in isolated fetal rat calvaria cells in vitro

1989 • 263 citations

Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma.

1991 • 256 citations

Interleukin-6 is produced by bone and modulated by parathyroid hormone

1989 • 237 citations

Chinese Hamster Ovarian Cells Transfected with the Murine lnterleukin-6 Gene cause Hypercalcemia as well as Cachexia, Leukocytosis and Thrombocytosis in Tumor-Bearing Nude Mice

1991 • 207 citations

Structure of the Rat Interleukin 6 Gene and Its Expression in Macrophage-derived Cells

1989 • 199 citations

Interleukin-6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone: Regulation by interleukin-1

1991 • 111 citations

Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter.

1992 • 101 citations

The coordinated regulation of fibrinogen gene transcription by hepatocyte-stimulating factor and dexamethasone.

1987 • 100 citations

Interleukin 4 induces interleukin 6 production by endothelial cells: Synergy with interferon‐γ

1991 • 74 citations

Human osteoblastlike cells do not respond to interleukin-6

1991 • 63 citations

Glucocorticosteroid‐dependent synergy between interleukin 1 and interleukin 6 for human B lymphocyte differentiation

1988 • 59 citations

Effects of interleukin-6 on cellular function in UMR-106–01 osteoblastlike cells

1991 • 46 citations

Stimulation of the differentiation of osteogenic rat bone marrow stromal cells by osteoblast cultures.

1991 • 32 citations