Structure of the Rat Interleukin 6 Gene and Its Expression in Macrophage-derived Cells

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Dideoxy sequencing method using denatured plasmid templates

1986 • 1,537 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

1988 • 793 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Multiple actions of interleukin 6 within a cytokine network

1988 • 536 citations

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

1987 • 509 citations

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

1989 • 470 citations

Interleukin 6 is involved in interleukin 1‐induced activities

1988 • 422 citations

The rat serum albumin gene: analysis of cloned sequences.

1979 • 400 citations

A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro

1986 • 391 citations

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

1988 • 382 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

The current status and portability of our sequence handling software

1986 • 357 citations

Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells

1987 • 299 citations

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

1988 • 297 citations

[7] Random cloning and sequencing by the M13/dideoxynucleotide chain termination method

1987 • 292 citations

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

1988 • 292 citations

Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.

1988 • 261 citations

Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat, and mouse.

1984 • 225 citations

L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein

1986 • 218 citations

Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.

1987 • 199 citations

Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.

1988 • 183 citations

Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.

1987 • 182 citations

Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblasts

1987 • 181 citations

Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

1988 • 174 citations

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

1987 • 145 citations

Regulation of major acute-phase plasma proteins by hepatocyte-stimulating factors of human squamous carcinoma cells.

1986 • 137 citations

Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocyte-stimulating factor/interleukin 6 gene in virus-infected human fibroblasts.

1988 • 131 citations

Interleukin-1β is a potent growth inhibitor of adult rat hepatocytes in primary culture

1988 • 126 citations

Genes for IFN-beta-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals.

1988 • 119 citations

Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin‐1, and epidermal growth factor in human fibroblasts

1987 • 85 citations

Modified nuclear processing of alpha 1-acid glycoprotein RNA during inflammation.

1987 • 81 citations

Structure and acute-phase regulation of the rat .alpha.2-macroglobulin gene

1988 • 59 citations

Organization of the R family and other interspersed repetitive DNA sequences in the mouse genome

1983 • 55 citations

Regulation of Rat Liver Acute Phase Genes by Interleukin‐6 and Production of Hepatocyte Stimulating Factors by Rat Hepatoma Cells^a

1989 • 41 citations

Hepatocytes Produce Interleukin‐6^a

1989 • 37 citations

Sequence analysis of the putative regulatory region of rat α2-macroglobulin gene

1987 • 37 citations

Age‐associated increase in the expression of T cell antigen receptor γ chain genes in mice

1988 • 15 citations

Weight loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor/cachectin activity in peritoneal macrophages.

1988 • 5 citations