Apoptotic Response to 5-Fluorouracil Treatment Is Mediated by Reduced Polyamines, Non-Autocrine Fas Ligand and Induced Tumor Necrosis Factor Receptor 2

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

2000 • 819 citations

Chemosensitivity prediction by transcriptional profiling

2001 • 673 citations

Metabolism and mechanism of action of 5-fluorouracil

1990 • 431 citations

Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

2001 • 400 citations

DNA Microarrays in Clinical Oncology

2002 • 383 citations

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

2002 • 379 citations

An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines.

2002 • 243 citations

Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling.

1999 • 190 citations

Genome-wide cDNA microarray screening to correlate gene expression profiles with sensitivity of 85 human cancer xenografts to anticancer drugs.

2002 • 181 citations

An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

1997 • 155 citations

Identifying Differentially Expressed Genes in cDNA Microarray Experiments

2001 • 114 citations

Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis

1997 • 94 citations

Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer

1990 • 71 citations

Obtaining reliable information from minute amounts of RNA using cDNA microarrays

2002 • 71 citations

Measurement of plasma 5-fluorouracil by high-performance liquid chromatography with comparison of results to tissue drug levels observed using in vivo 19F magnetic resonance spectroscopy in patients on a protracted venous infusion with or without interferon-α

1996 • 59 citations

RPR‐115135, a farnesyltransferase inhibitor, increases 5‐FU‐ cytotoxicity in ten human colon cancer cell lines: Role of p53

2002 • 44 citations

Assessment of tumor necrosis factor receptor and Fas signaling pathways by transcriptional profiling.

2001 • 35 citations