An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

1974 • 619 citations

The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processing

1990 • 449 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Identification and functional analysis of two U3 binding sites on yeast pre-ribosomal RNA.

1992 • 257 citations

Small Nuclear RNAs: RNA Sequences, Structure, and Modifications

1988 • 202 citations

Processing of Eukaryotic Ribosomal RNA

1994 • 200 citations

The Enzymatic Synthesis of D-Alanyl-D-alanine. III. On the Inhibition of D-Alanyl-D-alanine Synthetase by the Antibiotic D-Cycloserine^*

1964 • 173 citations

Inhibition of Ribosomal Ribonucleic Acid Maturation in Novikoff Hepatoma Cells by 5-Fluorouracil and 5-Fluorouridine

1973 • 157 citations

Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo

1981 • 148 citations

5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity.

1984 • 105 citations

A reinvestigation of 5′→3′ polarity in 40S ribosomal RNA precursor of xenopus laevis

1976 • 104 citations

“Thymineless” death in androgen-independent prostatic cancer cells

1989 • 101 citations

Regulation of ribosomal gene transcription

1995 • 100 citations

Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators

1991 • 99 citations

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil.

1994 • 94 citations

U3 small nuclear RNA can be psoralen-cross-linked in vivo to the 5' external transcribed spacer of pre-ribosomal-RNA.

1989 • 94 citations

hnRNA size and processing as related to different DNA content in two dipterans: Drosophila and aedes

1975 • 94 citations

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.

1987 • 93 citations

The 5′ end of U3 snRNA can be crosslinked in vivo to the external transcribed spacer of rat ribosomal RNA precursors

1989 • 92 citations

The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells.

1980 • 92 citations

Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU) RNA

1980 • 78 citations

5-Fluorouracil substitution alters pre-mRNA splicing in vitro.

1988 • 71 citations

A new interaction between the mouse 5′ external transcribed spacer of pre-rRNA and U3 snRNA detected by psoralen crosslinking

1992 • 63 citations

Specific inhibition of transfer RNA methylation and modification in tissues of mice treated with 5-fluorouracil.

1978 • 60 citations

The first pre-rRNA-processing event occurs in a large complex: analysis by gel retardation, sedimentation, and UV cross-linking.

1990 • 59 citations

The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro

1986 • 56 citations

Effects of 5-fluorouracil on dihydrofolate reductase and dihydrofolate reductase mRNA from methotrexate-resistant KB cells.

1985 • 52 citations

Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells

1990 • 47 citations

Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine

1989 • 46 citations

Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism.

1986 • 44 citations

5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells.

1983 • 41 citations

Mechanisms of resistance to fluoropyrimidines.

1992 • 39 citations

The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.

1979 • 39 citations

Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing.

1994 • 37 citations

Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA.

1984 • 37 citations

5-Fluorouracil augmentation of dihydrofolate reductase gene transcripts containing intervening sequences in methotrexate-resistant KB cells.

1986 • 34 citations

The effect of 5-fluorouridine 5'-triphosphate on RNA transcribed in isolated nuclei in vitro.

1980 • 28 citations

Augmentation by thymidine of the incorporation and distribution of 5-fluorouracil in ribosomal RNA

1979 • 26 citations

5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole.

1989 • 26 citations

Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA

1976 • 24 citations

5-Fluorouracil augmentation of dihydrofolate reductase RNA containing contiguous exon and intron sequences in KB7B cells.

1987 • 20 citations

Systemic therapy for colorectal cancer: an overview.

1991 • 18 citations

Analysis of the effect of 5-fluorouracil on the synthesis and translation of polysomal poly(A)RNA from Ehrlich ascites cells.

1981 • 18 citations

Current Role of Chemotherapy in Head and Neck Cancer

1992 • 13 citations

Mutagenesis of bacteriophage PBS 2

1973 • 11 citations

The effects of fluorouracil and actinomycin, single and combined, on the nucleolar ultrastructure of various tissues of the rat

1969 • 10 citations

In vitro splicing of pre-messenger RNA with extracts from 5-fluorouridine-treated cells

1994 • 7 citations

RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells.

1992 • 4 citations