The quality of maximum likelihood estimates of ion channel rate constants

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

Data transformations for improved display and fitting of single-channel dwell time histograms

1987 • 828 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

On the stochastic properties of bursts of single ion channel openings and of clusters of bursts

1982 • 564 citations

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

1996 • 432 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

Estimating kinetic constants from single channel data

1983 • 307 citations

Maximum likelihood estimation of aggregated Markov processes

1997 • 273 citations

Single‐channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

1998 • 231 citations

Activation of ion channels in the frog end‐plate by high concentrations of acetylcholine.

1988 • 214 citations

Activation of acetylcholine receptors on clonal mammalian BC3H‐1 cells by high concentrations of agonist.

1987 • 194 citations

Spontaneous openings of the acetylcholine receptor channel.

1984 • 162 citations

A general solution to the time interval omission problem applied to single channel analysis

1985 • 143 citations

Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.

1989 • 137 citations

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit.

1997 • 135 citations

A note on correlations in single ion channel records

1987 • 132 citations

Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events

1992 • 121 citations

Ion-channel gating mechanisms: model identification and parameter estimation from single channel recordings

1989 • 119 citations

A re‐examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics

1999 • 103 citations

Dependence of acetylcholine receptor channel kinetics on agonist concentration in cultured mouse muscle fibres.

1988 • 99 citations

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits

2003 • 89 citations

Nicotinic Receptor Fourth Transmembrane Domain

2000 • 87 citations

Yet another approach to the dwell-time omission problem of single-channel analysis

1990 • 77 citations

Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels

2002 • 75 citations

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant L221F, inferred from maximum likelihood fits

2003 • 72 citations

Kinetic, Mechanistic, and Structural Aspects of Unliganded Gating of Acetylcholine Receptor Channels

2000 • 72 citations

Adjacent interval analysis distinguishes among gating mechanisms for the fast chloride channel from rat skeletal muscle.

1989 • 50 citations

Theory of the kinetic analysis of patch-clamp data

1987 • 48 citations

Single-channel autocorrelation functions: the effects of time interval omission

1988 • 47 citations

Dependency plots suggest the kinetic structure of ion channels

1992 • 46 citations

Single channel currents at six microsecond resolution elicited by acetylcholine in mouse myoballs

1998 • 42 citations

Expression of cloned receptor subunits produces multiple receptors

1990 • 29 citations

Structural elements near the C‐terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision

2000 • 27 citations

Single-channel data and missed events

1990 • 15 citations