Ian4 is required for mitochondrial integrity and T cell survival

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

1991 • 1,505 citations

The machinery of programmed cell death

2001 • 830 citations

Mitochondrial Biogenesis and Remodeling during Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone

2003 • 445 citations

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

2000 • 428 citations

Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.

1996 • 273 citations

Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene

2002 • 218 citations

The Diabetes-Prone BB Rat Carries a Frameshift Mutation inIan4, a Positional Candidate ofIddm1

2002 • 158 citations

Vaccination with Empty Plasmid DNA or CpG Oligonucleotide Inhibits Diabetes in Nonobese Diabetic Mice: Modulation of Spontaneous 60-kDa Heat Shock Protein Autoimmunity

2000 • 147 citations

Differential effects of Bcl-2 on T and B cells in transgenic mice.

1992 • 140 citations

Pro-caspase-8 Is Predominantly Localized in Mitochondria and Released into Cytoplasm upon Apoptotic Stimulation

2001 • 125 citations

Mitochondria: regulating the inevitable

2002 • 121 citations

Animal Models in Diabetes: A Primer

2000 • 109 citations

Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration.

1983 • 76 citations

Molecular steps of cell suicide: an insight into immune senescence.

2000 • 67 citations

Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin

1997 • 65 citations

Antigen Activation Rescues Recent Thymic Emigrants from Programmed Cell Death in the BB Rat

1998 • 56 citations

High Frequency Apoptosis of Recent Thymic Emigrants in the Liver of Lymphopenic Diabetes-Prone BioBreeding Rats

1998 • 55 citations

Untitled

1997 • 54 citations

Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity

2001 • 46 citations

Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HepG2)

1994 • 38 citations

Theiddm4Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4Rats

2002 • 31 citations

The Rat T-Cell Surface Protein RT6 Is Associated With src Family Tyrosine Kinases and Generates an Activation Signal

1996 • 16 citations