Antigen Activation Rescues Recent Thymic Emigrants from Programmed Cell Death in the BB Rat

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.

1989 • 455 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

1996 • 418 citations

Functions of Rat T‐Lymphocyte Subsets Isolated by Means of Monoclonal Antibodies

1983 • 330 citations

MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses

1984 • 305 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Genetic dissection of autoimmune type I diabetes in the BB rat

1992 • 218 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.

1986 • 179 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

1981 • 155 citations

Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues.

1993 • 139 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

Upregulation of surface markers on dying thymocytes.

1995 • 122 citations

Identification of DNA-replicating lymphocyte subsets using a new method to label the bromo-deoxyuridine incorporated into the DNA

1992 • 118 citations

Cell division in the compartment of naive and memory T lymphocytes

1996 • 84 citations

Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.

1986 • 83 citations

Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium.

1993 • 80 citations

Thymic T cell export is not influenced by the peripheral T cell pool

1997 • 66 citations

Abnormalities in the Export and Fate of Recent Thymic Emigrants in Diabetes-Prone BB/W Rats¹

1996 • 52 citations

Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects.

1988 • 49 citations

Differential contribution of thymic outputs and peripheral expansion in the development of peripheral T cell pools

1994 • 48 citations

Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

1986 • 42 citations

Abnormal thymocyte maturation in spontaneously diabetic BB rats involves the deletion of CD4-8+ cells.

1990 • 39 citations

Abnormal thymocyte subset distribution and differential reduction of CD4+ and CD8+ T cell subsets during peripheral maturation in diabetes-prone BioBreeding rats.

1996 • 34 citations

Immunologic and genetic studies of diabetes in the BB rat.

1989 • 34 citations

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

1994 • 32 citations

High-Frequency, but Reduced Absolute Numbers of Recent Thymic Migrants among Peripheral Blood T Lymphocytes in Diabetes-Prone BB Rats

1995 • 24 citations

Increased incidence of Ia antigen-bearing T lymphocytes in the spontaneously diabetic BB rat.

1985 • 23 citations

Peripheral T cells in diabetes prone (DP) BB rats are CD45R-negative.

1989 • 18 citations

Loss of Rt6 Message and Most Circulating T Cells after Thymectomy of Diabetes Prone BB Rats

1994 • 17 citations

The Influence of T-Lymphocyte Precursor Cells and Thymus Grafts on the Cellular Immunodeficiencies of the BB Rat

1985 • 13 citations

Monoclonal Antibodies to RT7 and LCA Antigens in the Rat: Cell Distribution and Segregation Analysis

1987 • 12 citations

Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals

1998 • 12 citations

"Activated" T-lymphocyte levels in the spontaneously diabetic BB rat syndrome.

1985 • 11 citations

The influence of T-lymphocyte precursor cells and thymus grafts on the cellular immunodeficiencies of the BB rat

1985 • 10 citations