Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies.

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)

1972 • 1,816 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

1979 • 1,178 citations

[17] Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis

1983 • 1,115 citations

Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine

1982 • 975 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.

1981 • 544 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

1984 • 404 citations

The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies.

1984 • 371 citations

Profiles of Antinuclear Antibodies in Systemic Rheumatic Diseases

1975 • 365 citations

Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein

1983 • 333 citations

Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome.

1984 • 178 citations

Physical Association of Two Nuclear Antigens and Mutual Occurrence of Their Antibodies: The Relationship of the Sm and Rnaprotein (MO) Systems in Sle Sera

1973 • 145 citations

Purification of snRNPs U1, U2, U4, U5 and U6 with 2,2,7-trimethylguanosine-specific antibody and definition of their constituent proteins reacting with anti-Sm and anti-(U1)RNP antisera.

1983 • 143 citations

Immunoglobulin synthesis by peripheral blood cells in systemic lupus erythematosus

1975 • 131 citations

Autoantibodies to ribonucleoprotein particles containing U2 small nuclear RNA.

1985 • 85 citations

Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm.

1985 • 82 citations

5'-terminal caps of snRNAs are accessible for reaction with 2,2,7-trimethylguanosine-specific antibody in intact snRNPs.

1983 • 66 citations

Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation.

1983 • 57 citations

Role of the Sm antigen in the generation of anti-Sm autoantibodies in the SLE-prone MRL mouse.

1986 • 48 citations

Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies.

1985 • 45 citations

H-2-linked Ir gene control of T cell recognition of the Sm nuclear autoantigen and the aberrant response of autoimmune MRL/Mp-+/+ mice.

1985 • 16 citations

T cell recognition of the Sm nuclear antigen: induction of T cell proliferative responses in MRL/Mp- +/+ mice.

1982 • 12 citations

Identical Specificity of Lupus Antibodies and Antibodies Elicited in Rabbits Against Sm and RNP Antigens

1984 • 11 citations